Results 61 to 70 of about 24,572,306 (303)

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Viral Diseases of the Central Nervous System [PDF]

Journal of Clinical Pathology, 1976
  +6 more sources

Contribution of CNS and extra-CNS infections to neurodegeneration: a narrative review

Journal of Neuroinflammation
Central nervous system infections have been suggested as a possible cause for neurodegenerative diseases, particularly sporadic cases. They trigger neuroinflammation which is considered integrally involved in neurodegenerative processes.
Pinja Kettunen, Jari Koistinaho, Taisia Rolova   +2 more
doaj   +1 more source

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source

Elucidating the Neuropathologic Mechanisms of SARS-CoV-2 Infection

Frontiers in Neurology, 2021
The current pandemic caused by the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a public health emergency. To date, March 1, 2021, coronavirus disease 2019 (COVID-19) has caused about 114 million accumulated cases and 2.53 ...
Mar Pacheco-Herrero, Luis O. Soto-Rojas, Charles R. Harrington, Yazmin M. Flores-Martinez, Marcos M. Villegas-Rojas, Alfredo M. León-Aguilar, Paola A. Martínez-Gómez, B. Berenice Campa-Córdoba, B. Berenice Campa-Córdoba, Ricardo Apátiga-Pérez, Ricardo Apátiga-Pérez, Carolin N. Corniel-Taveras, Jesabelle de J. Dominguez-García, Víctor Manuel Blanco-Alvarez, José Luna-Muñoz, José Luna-Muñoz   +15 more
doaj   +1 more source

Neurovascular Contacts in the Pathophysiology of Neuralgic Amyotrophy: An Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuralgic amyotrophy (NA) is a prevalent, monophasic, multifocal immune‐mediated neuropathy. A distinctive characteristic of the disease is the occurrence of nerve or fascicle constrictions and torsions (NA‐associated focal nerve lesions, NAFL). The pathophysiology underlying this phenomenon remains to be fully elucidated.
Johannes Fabian Holle, Andreas Leha, Volker Limmroth, Wolfram Windisch, Maximilian Zimmermann   +4 more
wiley   +1 more source

Emergence and re-emergence of viral diseases of the central nervous system

Progress in Neurobiology, 2010
(Uploaded by Plazi for the Bat Literature Project) Neurologic disease is a major cause of disability in resource-poor countries and a substantial portion of this disease is due to infections of the CNS. A wide variety of emerging and re-emerging viruses contribute to this disease burden. New emerging infections are commonly due to RNA viruses that have
openaire   +3 more sources

Local nitric oxide production in viral and autoimmune diseases of the central nervous system. [PDF]

Proceedings of the National Academy of Sciences, 1995
Because of the short half-life of NO, previous studies implicating NO in central nervous system pathology during infection had to rely on the demonstration of elevated levels of NO synthase mRNA or enzyme expression or NO metabolites such as nitrate and nitrite in the infected brain.
D C, Hooper, S T, Ohnishi, R, Kean, Y, Numagami, B, Dietzschold, H, Koprowski   +5 more
openaire   +2 more sources

Conduction in segmentally demyelinated mammalian central axons. [PDF]

, 1997
The prominent symptoms associated with central demyelinating diseases such as multiple sclerosis (MS) are primarily caused by conduction deficits in affected axons.
Paul A. Felts, Baker, Theresa A., Theresa A. Baker, Felts, PA, Smith, KJ, Smith, Kenneth J., Felts, Paul A.; id_orcid, Kenneth J. Smith, Baker, TA   +8 more
core   +1 more source

MOGAD Is the Most Common Cause of Isolated Optic Neuritis in Children

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives The study aimed to characterize the clinical features, etiologies, and outcomes of isolated, first‐time pediatric ON in the post‐MOG‐IgG era. Methods This was a single‐center retrospective cohort study at Texas Children's Hospital of patients diagnosed with first‐time ON between 2018–2024, with follow‐up data collected through 2025.
Chaitanya Aduru, Akansha Chandrasekar, Kyla Blasingame, Jonathan Rosen, Jesse M. Levine, Karla Salazar, Madhuri Chilakapati, Rod Foroozan, Victoria Hardwick, Jonathan M. Yarimi, Nikita Shukla, Timothy E. Lotze, Kristen S. Fisher, Alexander J. Sandweiss   +13 more
wiley   +1 more source