Results 41 to 50 of about 24,572,306 (303)

Increased Hospitalizations for Neuropathies as Indicators of Zika Virus Infection, according to Health Information System Data, Brazil

Emerging Infectious Diseases, 2016
Evidence is increasing that Zika virus can cause extensive damage to the central nervous system, affecting both fetuses and adults. We sought to identify traces of possible clinical manifestations of nervous system diseases among the registers of ...
Christovam Barcellos, Diego Ricardo Xavier, Ana Luiza Pavão, Cristiano Siqueira Boccolini, Maria Fatima Pina, Marcel Pedroso, Dalia Romero, Anselmo Rocha Romão   +7 more
doaj   +1 more source

Epidemics of the central nervous system infections caused by West Nile virus in the territory of the South Bačka District, Vojvodina, Serbia [PDF]

Vojnosanitetski Pregled, 2015
Background/Aim. West Nile virus (WNV) is a neurotropic RNA virus particle which belongs to the Flaviviridae family, genus Flavivirus. It is sustained in arthropods within the transmission cycle between the mosquitoes and birds. Most commonly (80%
Sević Siniša, Stefan-Mikić Sandra, Šipovac Dragana, Turkulov Vesna, Milošević Vesna, Hrnjaković-Cvjetković Ivana   +5 more
doaj   +1 more source

The olfactory nerve: a shortcut for influenza and other viral diseases into the central nervous system [PDF]

The Journal of Pathology, 2014
AbstractThe olfactory nerve consists mainly of olfactory receptor neurons and directly connects the nasal cavity with the central nervous system (CNS). Each olfactory receptor neuron projects a dendrite into the nasal cavity on the apical side, and on the basal side extends its axon through the cribriform plate into the olfactory bulb of the brain ...
Debby van Riel, Rob Verdijk, Thijs Kuiken   +2 more
openaire   +3 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Small interfering RNAs based therapies for intracerebral hemorrhage: challenges and progress in drug delivery systems

Neural Regeneration Research, 2022
Intracerebral hemorrhage (ICH) is a subtype of stroke associated with higher rates of mortality. Currently, no effective drug treatment is available for ICH. The molecular pathways following ICH are complicated and diverse. Nucleic acid therapeutics such
Daniyah A Almarghalani, Sai H.S. Boddu, Mohammad Ali, Akhila Kondaka, Devin Ta, Rayyan A Shah, Zahoor A Shah   +6 more
doaj   +1 more source

ELR(+) chemokine signaling in host defense and disease in a viral model of central nervous system disease [PDF]

Frontiers in Cellular Neuroscience, 2014
Intracranial infection of the neurotropic JHM strain of mouse hepatitis virus (JHMV) into the central nervous system (CNS) of susceptible strains of mice results in an acute encephalomyelitis, accompanied by viral replication in glial cells and robust infiltration of virus-specific T cells that contribute to host defense through cytokine secretion and ...
Hosking, Martin P, Lane, Thomas E
openaire   +5 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Role of Microglia in Herpesvirus-Related Neuroinflammation and Neurodegeneration

Pathogens, 2022
Neuroinflammation is defined as an inflammatory state within the central nervous system (CNS). Microglia conprise the resident tissue macrophages of the neuronal tissue.
Magdalena Patrycy, Marcin Chodkowski, Malgorzata Krzyzowska   +2 more
doaj   +1 more source