Results 41 to 50 of about 151,906 (302)

Cure of chronic viral infection and virus-induced type 1 diabetes by neutralizing antibodies

, 2009
The use of neutralizing antibodies is one of the most successful methods to interfere with receptor–ligand interactions in vivo. In particular blockade of soluble inflammatory mediators or their corresponding cellular receptors was proven an effective ...
Christen, Urs, Ejrnaes, Mette, Herrath, Matthias G. von   +2 more
core   +1 more source

Epidemics of the central nervous system infections caused by West Nile virus in the territory of the South Bačka District, Vojvodina, Serbia [PDF]

Vojnosanitetski Pregled, 2015
Background/Aim. West Nile virus (WNV) is a neurotropic RNA virus particle which belongs to the Flaviviridae family, genus Flavivirus. It is sustained in arthropods within the transmission cycle between the mosquitoes and birds. Most commonly (80%
Sević Siniša, Stefan-Mikić Sandra, Šipovac Dragana, Turkulov Vesna, Milošević Vesna, Hrnjaković-Cvjetković Ivana   +5 more
doaj   +1 more source

Small interfering RNAs based therapies for intracerebral hemorrhage: challenges and progress in drug delivery systems

Neural Regeneration Research, 2022
Intracerebral hemorrhage (ICH) is a subtype of stroke associated with higher rates of mortality. Currently, no effective drug treatment is available for ICH. The molecular pathways following ICH are complicated and diverse. Nucleic acid therapeutics such
Daniyah A Almarghalani, Sai H.S. Boddu, Mohammad Ali, Akhila Kondaka, Devin Ta, Rayyan A Shah, Zahoor A Shah   +6 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

ELR(+) chemokine signaling in host defense and disease in a viral model of central nervous system disease [PDF]

Frontiers in Cellular Neuroscience, 2014
Intracranial infection of the neurotropic JHM strain of mouse hepatitis virus (JHMV) into the central nervous system (CNS) of susceptible strains of mice results in an acute encephalomyelitis, accompanied by viral replication in glial cells and robust infiltration of virus-specific T cells that contribute to host defense through cytokine secretion and ...
Hosking, Martin P, Lane, Thomas E
openaire   +5 more sources

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Role of Microglia in Herpesvirus-Related Neuroinflammation and Neurodegeneration

Pathogens, 2022
Neuroinflammation is defined as an inflammatory state within the central nervous system (CNS). Microglia conprise the resident tissue macrophages of the neuronal tissue.
Magdalena Patrycy, Marcin Chodkowski, Malgorzata Krzyzowska   +2 more
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Effective antiviral medicinal plants and biological compounds against central nervous system infections: A mechanistic review [PDF]

, 2019
Background and objective: Infectious diseases are amongst the leading causes of death in the world and central nervous system infections produced by viruses may either be fatal or generate a wide range of symptoms that affect global human health.
Rafieian-Kopaei, Mahmoud, Malekmohammad, Khojasteh, Sardari, Samira, Sewell, Robert D., Sewell, Robert D. E   +4 more
core   +1 more source