Results 51 to 60 of about 24,572,306 (303)

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Development survey of neurovirology

Chinese Journal of Contemporary Neurology and Neurosurgery, 2014
As a new subdiscipline, neurovirology derives from medical virology and neurology. Its research field includes both clinical practice of viral infectious diseases of the nervous system and fundamental research of medical virology.
De-xin WANG
doaj  

Crossing the blood-brain barrier: a review on drug delivery strategies for treatment of the central nervous system diseases [PDF]

, 2019
Many drugs have been designed to treat diseases of the central nervous system (CNS), especially neurodegenerative diseases. However, the presence of tight junctions at the blood-brain barrier has often compromised the efficiency of drug delivery to ...
Ling, King Hwa, Mohamed, Farahidah, Mansor, Nur Izzati, Rosli, Rozita, Nordin, Norshariza, Ling, King-Hwa, Hassan, Zurina   +6 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

The application values of cerebrospinal fluid cytological examination by slide centrifugation for diagnosis of central nervous system infectious diseases

Chinese Journal of Contemporary Neurology and Neurosurgery, 2013
According to the analysis of cerebrospnial fluid (CSF) cytological examination (by slide centrifugation) results of 15 940 central nervous system infectious cases, this cytologic examination method shows definite diagnostic values as follows: 1) better ...
Xiu-chu SU, Gang ZHAO, Yi-ning YANG, Wen DAI, Ting-ting LIU   +4 more
doaj  

Underestimated virus impaired cognition-more evidence and more work to do

Frontiers in Immunology
Neurodegenerative disorders (NDs) are chronic neurological diseases that can be of idiopathic, genetic, or potentially infectious origin. Although the exact cause of neurodegeneration is unknown, it might be result of a confluence of age, genetic ...
Maher Un Nisa Awan, Faisal Mahmood, Xiao-bin Peng, Xiao-bin Peng, Fenshuang Zheng, Jun Xu, Jun Xu   +6 more
doaj   +1 more source

Effects in the development of children exposed to zika virus in the fetal period: an integrative review [PDF]

Revista Brasileira de Enfermagem
Objective: To know the evidence available in the literature on the effects of the zika virus in children development after fetal exposure. Methods: This is an integrative literature review with 16 scientific articles found in five databases (PubMed ...
Gerarlene Ponte Guimarães Santos, Márcia Teles de Oliveira Gouveia, Rayla Maria Pontes Guimarães Costa, Ana Maria Ribeiro dos Santos, Fernanda Valéria Silva Dantas Avelino   +4 more
doaj   +4 more sources

Cytokines and neuron-specific proteins in pediatric viral encephalitis and convulsive syndrome. I. Viral encephalitis

Инфекция и иммунитет, 2020
Convulsive syndrome in children is manifested in the three forms: febrile convulsions in acute infections, symptomatic convulsions during acute neuroinfection, as well as onset of epilepsy requiring careful differentiation to prescribe adequate therapy ...
L. A. Alekseeva, G. F. Zheleznikova, E. Y. Gorelik, N. V. Skripchenko, A. A. Zhirkov   +4 more
doaj   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

T Cells in the Central Nervous System: The Delicate Balance between Viral Clearance and Disease [PDF]

The Journal of Infectious Diseases, 2002
The central nervous system (CNS) is considered an "immunoprivileged" site with restricted access and a unique microenvironment that profoundly affects the capacity of T cells to exert their functions. The lymphocytic choriomeningitis virus model offers a unique system in which to evaluate the contrasting roles of specific T cells in causing lethal CNS ...
Dorian B, McGavern, Dirk, Homann, Michael B A, Oldstone   +2 more
openaire   +2 more sources