Results 111 to 120 of about 1,358,589 (334)

Exploring antigenic variation in autoimmune endocrinopathy

Frontiers in Immunology
Autoimmune disorders develop owing to a misdirected immune response against self-antigen. Genetic studies have revealed that numerous variants in genes encoding immune system proteins are associated with the development of autoimmunity.
Maria Mavridou, Simon H. Pearce, Simon H. Pearce   +2 more
doaj   +1 more source

Early-season growth responses of corn hybrids and inbred lines to a commercial seed treatment [PDF]

, 2020
Annual rainfall in the Midwest has increased up to 10% since the early 20th century, while approximately 20-25% of the global corn crops have experienced yearly drought.
Vagedes, Rose
core  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Senolytic Vaccines from the Central and Peripheral Tolerance Perspective

Vaccines
Preventive medicine has proven its long-term effectiveness and economic feasibility. Over the last century, vaccination has saved more lives than any other medical technology.
Mariia I. Vasilieva, Rimma O. Shatalova, Kseniia S. Matveeva, Vadim V. Shindyapin, Ekaterina Minskaia, Roman A. Ivanov, Daniil V. Shevyrev   +6 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Transcriptomic profiling of thymic dysregulation and viral tropism after neonatal roseolovirus infection

Frontiers in Immunology
IntroductionHerpesviruses, including the roseoloviruses, have been linked to autoimmune disease. The ubiquitous and chronic nature of these infections have made it difficult to establish a causal relationship between acute infection and subsequent ...
Andrei Belean, Eden Xue, Benjamin Cisneros, Elisha D. O. Roberson, Elisha D. O. Roberson, Elisha D. O. Roberson, Michael A. Paley, Michael A. Paley, Tarin M. Bigley, Tarin M. Bigley, Tarin M. Bigley   +10 more
doaj   +1 more source

Zero tolerance policing: new authoritarianism or new liberalism? [PDF]

, 2002
The notion of “zero tolerance” policing has been widely discussed in the media in recent years and has received considerable support from politicians right across the political spectrum both in the USA and the UK. Proponents of this apparently “get-tough”
Hopkins Burke, RD
core  

Biochemical Markers of Environmental Stress Tolerance in Finger Millet [Eleusine coracana (L) Gaertn] Germplasm of Central Himalayan Region [PDF]

, 2021
Ajaya Kumar Trivedi, S. K. Verma, Rishi Tyagi, A. Hemanataranjan   +3 more
openalex   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Imputing Risk Tolerance from Survey Responses [PDF]

Economic theory assigns a central role to risk preferences. This paper develops a measure of relative risk tolerance using responses to hypothetical income gambles in the Health and Retirement Study.
Claudia R. Sahm, Matthew D. Shapiro, Miles S. Kimball   +2 more
core