Results 201 to 210 of about 448,542 (245)
Some of the next articles are maybe not open access.

Related searches:

Central Tolerance of T Cells

International Reviews of Immunology, 1995
The immune system is constructed to tolerate self antigens but give vigorous responses to foreign antigens. How this state of self/nonself discrimination is maintained is controversial. In the case of T cells, many self antigens are transported to the thymus via the bloodstream and induce tolerance (clonal deletion) of self-reactive thymocytes in situ.
exaly   +3 more sources

A CENTRAL ROLE FOR CENTRAL TOLERANCE

Annual Review of Immunology, 2006
Recent elucidation of the role of central tolerance in preventing organ-specific autoimmunity has changed our concepts of self/nonself discrimination. This paradigmatic shift is largely attributable to the discovery of promiscuous expression of tissue-restricted self-antigens (TRAs) by medullary thymic epithelial cells (mTECs).
Bruno, Kyewski, Ludger, Klein
openaire   +2 more sources

Redefining thymus medulla specialization for central tolerance [PDF]

open access: yesJournal of Experimental Medicine, 2017
Emilie J Cosway   +2 more
exaly   +2 more sources

Central Tolerance Induction

2013
A critical function of the thymus is to help enforce tolerance to self. The importance of central tolerance in preventing autoimmunity has been enlightened by a deeper understanding of the interactions of developing T cells with a diverse population of thymic antigen presenting cell populations.
Maria L, Mouchess, Mark, Anderson
openaire   +2 more sources

The Thymus and Central Tolerance

Hormone and Metabolic Research, 1996
Thymic selection programs T lymphocytes to tolerate self antigens but respond to foreign antigens. The mechanisms involved in self tolerance induction are discussed.
openaire   +2 more sources

Chimerism and central tolerance

Current Opinion in Immunology, 1996
With adequate depletion or inactivation of the pre-existing immune system and establishment of conditions permitting donor hematopoietic stem cell engraftment, a robust state of central deletional tolerance to allogeneic or xenogeneic donors can be induced.
openaire   +2 more sources

Home - About - Disclaimer - Privacy