Results 201 to 210 of about 448,542 (245)
Long-Term Trends of Striped Bass Habitat Suitability Under a Temperature-Oxygen Squeeze in Lake Texoma, Oklahoma and Texas. [PDF]
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International Reviews of Immunology, 1995
The immune system is constructed to tolerate self antigens but give vigorous responses to foreign antigens. How this state of self/nonself discrimination is maintained is controversial. In the case of T cells, many self antigens are transported to the thymus via the bloodstream and induce tolerance (clonal deletion) of self-reactive thymocytes in situ.
exaly +3 more sources
The immune system is constructed to tolerate self antigens but give vigorous responses to foreign antigens. How this state of self/nonself discrimination is maintained is controversial. In the case of T cells, many self antigens are transported to the thymus via the bloodstream and induce tolerance (clonal deletion) of self-reactive thymocytes in situ.
exaly +3 more sources
Intrathymic Regulation of Dendritic Cell Subsets and Their Contributions to Central Tolerance [PDF]
Lauren I R Ehrlich
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A CENTRAL ROLE FOR CENTRAL TOLERANCE
Annual Review of Immunology, 2006Recent elucidation of the role of central tolerance in preventing organ-specific autoimmunity has changed our concepts of self/nonself discrimination. This paradigmatic shift is largely attributable to the discovery of promiscuous expression of tissue-restricted self-antigens (TRAs) by medullary thymic epithelial cells (mTECs).
Bruno, Kyewski, Ludger, Klein
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Redefining thymus medulla specialization for central tolerance [PDF]
Emilie J Cosway +2 more
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2013
A critical function of the thymus is to help enforce tolerance to self. The importance of central tolerance in preventing autoimmunity has been enlightened by a deeper understanding of the interactions of developing T cells with a diverse population of thymic antigen presenting cell populations.
Maria L, Mouchess, Mark, Anderson
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A critical function of the thymus is to help enforce tolerance to self. The importance of central tolerance in preventing autoimmunity has been enlightened by a deeper understanding of the interactions of developing T cells with a diverse population of thymic antigen presenting cell populations.
Maria L, Mouchess, Mark, Anderson
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The Thymus and Central Tolerance
Hormone and Metabolic Research, 1996Thymic selection programs T lymphocytes to tolerate self antigens but respond to foreign antigens. The mechanisms involved in self tolerance induction are discussed.
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Chimerism and central tolerance
Current Opinion in Immunology, 1996With adequate depletion or inactivation of the pre-existing immune system and establishment of conditions permitting donor hematopoietic stem cell engraftment, a robust state of central deletional tolerance to allogeneic or xenogeneic donors can be induced.
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