Results 211 to 220 of about 448,542 (245)

Tolerance to centrally administered phenobarbital

Biochemical Pharmacology, 1976
Abstract Rats with permanent indwelling cerebral ventricular cannulae were shown to lose their righting reflex in response to centrally injected phenobarbital in a dose-related manner. Administration of four daily injections of 800 μg each over a 4- to 5-day period produced a gradual tolerance to the hypnotic effect, which was reversible after ...
M J, Mycek, H E, Brezenoff
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Central tolerance: good but imperfect

Immunological Reviews, 2006
Summary:  T‐cell development is a highly coordinated process that depends on interactions between thymocytes, thymic epithelium, and bone marrow (BM)‐derived dendritic cells (DCs). Before entering the peripheral T‐cell pool, thymocytes are subject to negative selection, a process that eliminates (or deletes) T cells with high affinity toward self ...
Alena M, Gallegos, Michael J, Bevan
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CCR4 promotes medullary entry and thymocyte–dendritic cell interactions required for central tolerance [PDF]

Journal of Experimental Medicine, 2015
Zicheng Hu, Jessica N Lancaster, Lauren I R Ehrlich   +2 more
exaly   +2 more sources

Cross-tolerance to centrally injected barbiturates

European Journal of Pharmacology, 1979
Hypnotic responses to intracerebroventricular (i.c.v) injections of either barbital, pentobarbital, R(-) and S(+) mephorbarbital, or racemic metharbital were compared to those produced by phenobarbital. Dose--response relationships were obtained for all except S(+) mephorbarbital and metharbital. Chronic i.c.v.
W H, Lyness, H E, Brezenoff, M J, Mycek
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A defect in central tolerance in NOD mice

Nature Immunology, 2001
The predisposition of nonobese diabetic (NOD) mice to develop autoimmune disease is usually attributed to defects in peripheral tolerance mechanisms. Here, evidence is presented that NOD mice display a defect in central tolerance (negative selection) of thymocytes. Impaired central tolerance in NOD mice was most prominent in a population of semi-mature
H, Kishimoto, J, Sprent
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Medullary interplay for central tolerance

Blood, 2011
To establish central tolerance in T cells, Aire, a nuclear protein expressed in medullary thymic epithelial cells, not only induces the ectopic expression of various self-antigens but also facilitates the indirect presentation of medullary thymic epithelial cell (mTEC)–derived self-antigens ...
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Tolerance and cross-tolerance to mescaline and amphetamine as a function of central and peripheral administration

Psychopharmacologia, 1972
Differences in tolerance and cross-tolerance to the behavioral effects of d-amphetamine sulfate and mescaline hydrochloride were studied as a function of intraventricular or intraperitoneal routes of administration. Operant behavior, using a fixed ratio schedule of food reinforcement, was the behavioral variable.
S B, Sparber, H A, Tilson
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Tissue Tolerance: Central Nervous System

Radiology, 1968
IN 1958 LAMPE (13) surveyed the experience to date with radiation tolerance of the central nervous system. He concluded that, as of that time, precise radiation tolerance limits of the central nervous system were not known for clinical radio-therapeutic practice. This still holds true today.
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A Nondeletional Mechanism for Central T-Cell Tolerance

Critical Reviews™ in Immunology, 2001
To be positively selected, immature thymocytes must receive signaling through their T-cell receptor (TCR), and engagement of relatively low-affinity self-peptides permits further T-cell maturation. However, mature T cells no longer overtly respond to such low-affinity antigens, indicating that T cells acquire a higher threshold for activation during ...
R L, Rubin, A, Kretz-Rommel
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A unified theory of central tolerance in the thymus

Trends in Immunology, 2006
Non-deletional tolerance resulting in the generation of regulatory T cells within the thymus is a key mechanism for the establishment of immunological self-tolerance. How the high-affinity self-reactive regulatory T cells escape negative selection and what type of antigen-presenting cells positively select them within the thymus are unsolved questions.
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