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Antigen presentation for central tolerance induction

Nature Reviews Immunology
The extent of central T cell tolerance is determined by the diversity of self-antigens that developing thymocytes 'see' on thymic antigen-presenting cells (APCs). Here, focusing on insights from the past decade, we review the functional adaptations of medullary thymic epithelial cells, thymic dendritic cells and thymic B cells for the purpose of ...
Ludger, Klein, Elisabetta, Petrozziello
openaire   +2 more sources

GDF15 Is an Inflammation-Induced Central Mediator of Tissue Tolerance

Cell, 2019
Harding H Luan   +2 more
exaly  

The Itaconate Pathway Is a Central Regulatory Node Linking Innate Immune Tolerance and Trained Immunity

Cell Metabolism, 2019
Jorge Dominguez-Andres   +2 more
exaly  

How defects in central tolerance impinge on a deficiency in regulatory T cells

Proceedings of the National Academy of Sciences of the United States of America, 2005
Zhibin Chen   +2 more
exaly  

Central Tolerance to Tissue-specific Antigens Mediated by Direct and Indirect Antigen Presentation

Journal of Experimental Medicine, 2004
Michael J Bevan, Bevan Michael J
exaly  

Big impact of microRNAs on central B cell tolerance

Nature Immunology, 2016
Eric Meffre, Meffre Eric
exaly  

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