Results 111 to 120 of about 271,718 (292)

Peer Effects and Social Networks in Education and Crime [PDF]

This paper studies whether structural properties of friendship networks affect individual outcomes in education and crime. We first develop a model that shows that, at the Nash equilibrium, the outcome of each individual embedded in a network is ...
Calvó-Armengol, Antoni, Patacchini, Eleonora, Zenou, Yves   +2 more
core  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Centrality based analysis of amino acids network [PDF]

Network Biology
A network is a crucial asset in biology for capturing and exploring interaction data in biological systems of many types, such as protein-protein communications, amino acid associations, gene regulation, and cellular metabolism.
Chandra Borah, Tazid Ali
doaj  

Modeling Minneapolis Skyway Network [PDF]

Adopting an agent-based approach, this paper explores the topological evolution of the Minneapolis Skyway System from a microscopic perspective. Under a decentralized decision-making mechanism, skyway segments are built by self-interested building owners.
Arthur Huang, David Levinson
core  

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Influential Yield Strength of Steel Materials with Return Random Walk Gravity Centrality

Mathematics
In complex networks, important nodes have a significant impact, both functional and structural. From the perspective of data flow pattern detection, the evaluation of the importance of a node in a network, taking into account the role it plays as a ...
Rocío Rodríguez, Manuel Curado, Francy D. Rodríguez, José F. Vicent   +3 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Analysis of amino acid network based on bond energy using graph mining techniques [PDF]

Network Biology
Amino acids are building blocks of proteins which are essential for all biological functions. Each amino acid has different physico-chemical characteristics.
Nasrin Irshad Hussain, Kuntala Boruah, Adil Akhtar   +2 more
doaj  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

An improved entropy centrality for detection of spam webpages

Cogent Engineering
Centrality is a popular network analysis concept. Spam nodes in social networks are detected using centrality measures. It classifies a node as influential or anomalous.
Divya S. Raj, Jaganathan B
doaj   +1 more source