Results 151 to 160 of about 27,287 (301)
eLife, 2013 Centrioles organise centrosomes and template cilia and flagella. Several centriole and centrosome proteins have been linked to microcephaly (MCPH), a neuro-developmental disease associated with small brain size. CPAP (MCPH6) and STIL (MCPH7) are required
Matthew A Cottee +9 more
doaj +1 more source
TTBK2‐Driven Ciliogenesis Is Required for Intrinsic Neuronal Regeneration After Spinal Cord Injury
CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.TTBK2‐dependent ciliogenesis is required for intrinsic neuronal regeneration after spinal cord injury. Loss of TTBK2 disrupts primary cilium integrity, attenuates SHH signaling, and impairs axonal regrowth. Restoring SHH activity partially rescues neuronal structural deficits, highlighting the TTBK2/cilium–SHH as a therapeutic target.
Renfeng Zhang +6 more
wiley +1 more source
The mother centriole plays an instructive role in defining cell geometry.
PLoS Biology, 2007 Centriole positioning is a key step in establishment and propagation of cell geometry, but the mechanism of this positioning is unknown. The ability of pre-existing centrioles to induce formation of new centrioles at a defined angle relative to ...
Jessica L Feldman +2 more
doaj +1 more source
, 2014 We introduce a formalism for the geometry of eukaryotic cells and organisms.Cells are taken to be star-convex with good biological reason. This allows for a convenient description of their extent in space as well as all manner of cell surface gradients ...
Morozova, Nadya, Penner, Robert
core +1 more source
Novel features of centriole polarity and cartwheel stacking revealed by cryo‐tomography
bioRxiv, 2020 Centrioles are polarized microtubule-based organelles that seed the formation of cilia, and which assemble from a cartwheel containing stacked ring oligomers of SAS-6 proteins.
S. Nazarov +7 more
semanticscholar +1 more source
The basal bodies of Chlamydomonas reinhardtii [PDF]
, 2016 The unicellular green alga, Chlamydomonas reinhardtii, is a biflagellated cell that can swim or glide. C. reinhardtii cells are amenable to genetic, biochemical, proteomic, and microscopic analysis of its basal bodies.
Dutcher, Susan, O\u27Toole, Eileen T
core +2 more sources
Bld10p/Cep135 determines the number of triplets in the centriole independently of the cartwheel [PDF]
, 2022 Akira Noga +5 more
openalex +1 more source
Cell Reports, 2014 Vertebrate centrioles lose their geometric scaffold, the cartwheel, during mitosis, concurrently with gaining the ability to recruit the pericentriolar material (PCM) and thereby function as the centrosome.
Denisse Izquierdo +3 more
doaj +1 more source
CEP44 and CCDC15 label the spermatozoa proximal and atypical distal centrioles. [PDF]
MicroPubl BiolAchinger L +7 more
europepmc +3 more sources
Abnormal photoreceptor outer segment development and early retinal degeneration in kif3a mutant zebrafish [PDF]
, 2016 Photoreceptors are highly specialized sensory neurons that possess a modified primary cilium called the outer segment. Photoreceptor outer segment formation and maintenance require highly active protein transport via a process known as intraflagellar ...
Akhtar +44 more
core +2 more sources