Results 121 to 130 of about 118,231 (380)
Neocentromeres Provide Chromosome Segregation Accuracy and Centromere Clustering to Multiple Loci along a Candida albicans Chromosome. [PDF]
PLoS Genetics, 2016 Assembly of kinetochore complexes, involving greater than one hundred proteins, is essential for chromosome segregation and genome stability. Neocentromeres, or new centromeres, occur when kinetochores assemble de novo, at DNA loci not previously ...
Laura S Burrack +12 more
doaj +1 more source
α-amino trimethylation of CENP-A by NRMT is required for full recruitment of the centromere
Nature Communications, 2017 Centromeres are unique chromosomal domains that control chromosome segregation, and are epigenetically specified by the presence of the CENP-A containing nucleosomes. CENP-A governs centromere function by recruiting the constitutive centromere associated
K. Sathyan, D. Fachinetti, D. Foltz
semanticscholar +1 more source
High-resolution mapping of heteroduplex DNA formed during UV-induced and spontaneous mitotic recombination events in yeast. [PDF]
, 2017 In yeast, DNA breaks are usually repaired by homologous recombination (HR). An early step for HR pathways is formation of a heteroduplex, in which a single-strand from the broken DNA molecule pairs with a strand derived from an intact DNA molecule.
Dominska, Margaret +3 more
core +3 more sources
Advanced Science, EarlyView.The GeneHunter‐Gene‐Level Association (GH‐GLA) pipeline enables high‐throughput gene identification in an indexed EMS population of wheat cultivar KN9204. It identifies 5905 trait‐associated wheat genes and validates key regulators of kernel weight and spikelet architecture via gene editing and haplotype analysis.
Haojie Wang +16 more
wiley +1 more source
CENP-A Ubiquitylation Is Inherited through Dimerization between Cell Divisions
Cell Reports, 2016 The presence of chromatin containing the histone H3 variant CENP-A dictates the location of the centromere in a DNA sequence-independent manner. But the mechanism by which centromere inheritance occurs is largely unknown. We previously reported that CENP-
Yohei Niikura +2 more
doaj +1 more source
eLife, 2020 The human fungal pathogen Cryptococcus deuterogattii is RNAi-deficient and lacks active transposons in its genome. C. deuterogattii has regional centromeres that contain only transposon relics.
Klaas Schotanus, Joseph Heitman
doaj +1 more source
Speciation Mediated by Centromeres [PDF]
Developmental Cell, 2013 Speciation accompanies reproductive isolation in natural populations through hybrid sterility or lethality. However, the molecular bases of hybrid lethality are mysterious. In this issue of Developmental Cell, Thomae et al. (2013) demonstrate that Drosophila speciation factors HMR and LHR form a centromeric complex and that increased dosage causes ...
openaire +3 more sources
A Computational Approach to Estimating Nondisjunction Frequency in Saccharomyces cerevisiae. [PDF]
, 2016 Errors segregating homologous chromosomes during meiosis result in aneuploid gametes and are the largest contributing factor to birth defects and spontaneous abortions in humans.
Burgess, Sean M, Chu, Daniel B
core +3 more sources
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Chromosomal aberrations, particularly copy‐number variations (CNVs), are prevalent in neurodevelopmental disorders (NDD) and significantly contribute to their pathogenesis. Copy‐number gains (CN gains) in 15q11‐q13, primarily consisting of a pseudo (iso‐)dicentric chromosome 15 [(i)dic(15)] or an interstitial duplication, are among the most ...
Sebastian Burkart +5 more
wiley +1 more source
A PSHaver for Centromeric Histones [PDF]
Molecular Cell, 2010 In this issue of Molecular Cell, Hewawasam et al. (2010) and Ranjitkar et al. (2010) identify and characterize Psh1, an E3 ubiquitin ligase that specifically targets the centromeric histone Cse4 in budding yeast and limits its misincorporation at noncentromeric regions.
H. Diego Folco, Arshad Desai
openaire +3 more sources