Results 131 to 140 of about 51,411 (295)

Cross‐Analysis of Single‐Cell Transcriptomic Datasets Reveals Conserved Neurogenic Gene Signatures and New Insights Into Neural Stem Cell Aging

open access: yesAging Cell, EarlyView.
Here, we reanalyze single‐cell RNA sequencing datasets demonstrating hippocampal adult neural stem cell (NSC) heterogeneity to resolve classification inconsistencies and identify conserved gene markers. Our findings enhance understanding of NSC dynamics, aging, and senescence, providing a framework for standardized classification and improved insights ...
Oliver Polzer   +4 more
wiley   +1 more source

Decoding the Role of CDCA Genes in Breast Cancer Progression: Insights From in Silico and Functional Assay

open access: yesAsia-Pacific Journal of Clinical Oncology, EarlyView.
Investigating the diagnostic potential and functional role of CDCA genes in breast cancer. ABSTRACT Background The cell division cycle‐associated (CDCA) genes regulate key cellular processes like cell cycle progression and division. This study evaluates the diagnostic and clinical relevance of CDCA genes in breast cancer.
Yongsheng Zhao, Xiaocha Ma, Jun Zhou
wiley   +1 more source

The use of deidentified organ donor testes for research

open access: yesAndrology, EarlyView.
Abstract Our knowledge of testis development and function mainly comes from research using mammalian model organisms, primarily the mouse. However, there are integral differences between men and other mammalian species regarding cellular composition and expression profiles during fetal and post‐natal testis development and in the mature testis ...
Marina V. Pryzhkova   +4 more
wiley   +1 more source

Cpf1 protein induced bending of yeast centromere DNA element I [PDF]

open access: green, 1993
Rainer Niedenthal   +3 more
openalex   +1 more source

Cerebellar defects are a primary pathology in mouse models of spinal muscular atrophy

open access: yesBrain Pathology, EarlyView.
Purkinje cell (PC) degeneration is localized to posterior lobules in the cerebellum, and rescue of survival motor neuron protein expression levels in motor neurons does not ameliorate this effect. Representative images of sagittal cerebellar sections stained with anti‐calbindin in the vermis and hemisphere at P12 for wild type, ChATCre+ rescue (Rescue),
Nicholas C. Cottam   +9 more
wiley   +1 more source

D7S448 detects aHindIII polymorphism located in the centromere region of chromosome 7 [PDF]

open access: green, 1991
Michael Dean   +6 more
openalex   +1 more source

Non‐canonical nitric oxide signalling and DNA methylation: Inflammation induced epigenetic alterations and potential drug targets

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract DNA methylation controls DNA accessibility to transcription factors and other regulatory proteins, thereby affecting gene expression and hence cellular identity and function. As epigenetic modifications control the transcriptome, epigenetic dysfunction is strongly associated with pathological conditions and ageing.
Christopher H. Switzer
wiley   +1 more source

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