ACR Open Rheumatology, Volume 8, Issue 3, March 2026.Objective Juvenile‐onset systemic sclerosis (jSSc) is a rare, heterogeneous pediatric autoimmune disease. Existing severity tools are often adapted from adult systemic sclerosis and lack pediatric‐specific validation. The Juvenile Systemic Sclerosis Severity Score (J4S) was developed to address this gap by capturing multiorgan disease burden.
Samantha A. Branton, Kathryn S. Torok
wiley +1 more source
Chromosome centromere copy number amplification associated with exceptional response in HER2-positive metastatic breast cancer patients. [PDF]
OncogeneAndrieu C +14 more
europepmc +1 more source
Lipid Droplet‐Localized Spindle Apparatus Coiled‐Coil Protein 1 Regulates Lipid Droplet Distribution
Advanced Science, Volume 13, Issue 14, 9 March 2026.SPDL1‐L, a long isoform of SPDL1, is identified as a bona fide lipid droplet‐associated protein that acts as a dynein adaptor to drive perinuclear clustering of lipid droplets. By linking lipid droplets to the microtubule network, SPDL1‐L extends the function of SPDL1 beyond mitosis and contributes to lipid droplet organization and nuclear remodeling ...
Honggang Su +10 more
wiley +1 more source
Assessing the concordance between centromere AC-3 immunofluorescence pattern and anti-centromere protein-B antibody, and analyzing clinical correlates of dual positivity: A retrospective study. [PDF]
Medicine (Baltimore)He S, Wu Y, Ke LP, Wu P, Xu DH.
europepmc +1 more source
EGR Proteins Mediate Interferon‐Independent Anti‐HSV‐1 Responses Through Viral and Host Targets
Advanced Science, Volume 13, Issue 13, 3 March 2026.Early antiviral responses are typically mediated by interferons. However, during HSV‐1 infection, host early growth response (Egr) genes, which are not interferon‐stimulated genes, are quickly induced by viral protein ICP0. EGR proteins, in turn, suppress viral lytic infection by activating viral latency‐associated (LAT) and host immune regulatory ...
Shuaishuai Wang +4 more
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Insights into natural neocentromere evolution from a cattle T2T X chromosome. [PDF]
Nat CommunPineda PS +14 more
europepmc +1 more source
Time‐Efficient and Informatic‐Skill‐Light Gap‐Filling for Telomere‐to‐Telomere Genome Assembly
Advanced Science, Volume 13, Issue 14, 9 March 2026.The paper introduces a novel auxiliary software toolbox GapSuite, consisting of two tools Gap‐Aid and Gap‐Graph, which guides users to fill gaps in chromosome‐level genome assembly using sequence‐extension‐based and assembly‐graph‐based strategies. The two tools enable users with limited informatics expertise to efficiently complete gap‐filling on ...
Dong Xu +8 more
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Heterochromatin boundaries maintain centromere position, size and number. [PDF]
Nat Struct Mol BiolCarty BL +11 more
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Transposon Ecology and the Octopus Genome
BioEssays, Volume 48, Issue 3, March 2026.Transposable elements (TEs) are mobile strands of DNA prevalent in octopus genomes. TE activity in the octopus brain might reflect an organism‐beneficial role in cognition; or could be a deleterious byproduct of TE parasitism. Viewing TEs from a genome‐ecology perspective generates novel predictions about differential expression levels across “genomic ...
Stefan Linquist +5 more
wiley +1 more source