Results 131 to 140 of about 88,605 (330)

RepeatOBserver: Tandem Repeat Visualisation and Putative Centromere Detection

open access: yesMolecular Ecology Resources, EarlyView.
ABSTRACT Tandem repeats play an important role in centromere structure, subtelomeric regions, DNA methylation, recombination and the regulation of gene activity. Analysis of their distribution in genomes offers a potential means for predicting putative centromere locations, which continues to be a challenge for genome annotation.
Cassandra Elphinstone   +3 more
wiley   +1 more source

Strong Signatures of Selection on Candidate Genes Underlying Core Speciation Mechanisms in Desert Tortoises

open access: yesMolecular Ecology Resources, EarlyView.
ABSTRACT Genomic incompatibilities and differential ecological adaptation are thought to be fundamental mechanisms of speciation. In this study, we generated a chromosome‐scale reference genome and annotation for Gopherus morafkai , the Sonoran Desert tortoise, and conducted a detailed analysis of genes under positive selection with its sister species,
Sarah M. Baty   +6 more
wiley   +1 more source

Cross‐Analysis of Single‐Cell Transcriptomic Datasets Reveals Conserved Neurogenic Gene Signatures and New Insights Into Neural Stem Cell Aging

open access: yesAging Cell, EarlyView.
Here, we reanalyze single‐cell RNA sequencing datasets demonstrating hippocampal adult neural stem cell (NSC) heterogeneity to resolve classification inconsistencies and identify conserved gene markers. Our findings enhance understanding of NSC dynamics, aging, and senescence, providing a framework for standardized classification and improved insights ...
Oliver Polzer   +4 more
wiley   +1 more source

Centromere assembly requires selective recognition of centromeric chromatin by centromere protein N

open access: yesThe FASEB Journal, 2008
The kinetochore is a unique chromosomal locus that binds to the mitotic spindle so that chromosomes can segregate in mitosis. Kinetochore assembly requires the specialized chromatin of the centromere that is distinguished by the replacement of histone H3 with the histone H3‐variant centromere protein A (CENP‐A). CENP‐A is thought to epigenetically mark
Christopher W. Carroll   +1 more
openaire   +2 more sources

Decoding the Role of CDCA Genes in Breast Cancer Progression: Insights From in Silico and Functional Assay

open access: yesAsia-Pacific Journal of Clinical Oncology, EarlyView.
Investigating the diagnostic potential and functional role of CDCA genes in breast cancer. ABSTRACT Background The cell division cycle‐associated (CDCA) genes regulate key cellular processes like cell cycle progression and division. This study evaluates the diagnostic and clinical relevance of CDCA genes in breast cancer.
Yongsheng Zhao, Xiaocha Ma, Jun Zhou
wiley   +1 more source

CENP-C unwraps the human CENP-A nucleosome through the H2A C-terminal tail

open access: yes, 2019
Centromeres are defined epigenetically by nucleosomes containing the histone H3 variant CENP-A, upon which the constitutive centromere-associated network of proteins (CCAN) is built. CENP-C is considered to be a central organizer of the CCAN.
Ali-Ahmad, A.   +4 more
core   +1 more source

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