Results 151 to 160 of about 88,605 (330)
Cancer Science, EarlyView.EBV‐ MTX‐DLBCL shows higher driver gene mutation rates and worse outcomes after MTX discontinuation compared to EBV+ MTX‐DLBCL. IDD‐LPDs have lower mutation rates in genes related to clonal hematopoiesis (TET2/DNMT3A) and immune evasion (CD58) compared to EBV + DLBCL. ABSTRACT The WHO recently changed the outline of immunodeficiency/dysregulation (IDD)‐
Takumi Takahashi +12 more
wiley +1 more source
Inconsistent expression of both centromeres of a dicentric Y chromosome in a child with ambiguous external genitalia. [PDF]
, 1978 B Fass +3 more
openalex +1 more source
TRAPPC2l Participates in Male Germ Cell Development by Regulating Cell Division
Cell Proliferation, EarlyView.Trappc2l is crucial for maintaining the quiescent state of male gonocytes. In the absence of Trappc2l, the quiescent state of gonocytes is disrupted, leading to premature and abnormal initiation of meiosis, which consequently results in subsequent abnormalities in sperm development. ABSTRACT TRAPPC2L is a core subunit of the Transport Protein Particle (
Mengyue Wang +8 more
wiley +1 more source
Analysis of centromere co-orientation in intervarietal hybrids of common wheat (Triticum aestivum L.), by means of C-banding [PDF]
, 1985 A. Fominaya, N. Jouve
openalex +1 more source
Cell Proliferation, EarlyView.PDHA2, a testis‐specific subunit of pyruvate dehydrogenase, is required for the conversion of pyruvate to acetyl‐CoA. Its absence results in decreased acetyl‐CoA and precursors for metabolites and energy during spermatogenesis. This results in decreased histone acetylation, defective chromosome structure and moderately reduced crossovers, ultimately ...
Guoqiang Wang +9 more
wiley +1 more source
Distribution of kinetochore (centromere) antigen in mammalian cell nuclei. [PDF]
, 1981 Y Möroi +3 more
openalex +1 more source
Cell Proliferation, EarlyView.Active nucleoli have the capability to release perinuclear heterochromatin, which is a novel event of iPSC reprogramming. ABSTRACT Ribosome biogenesis occurs within the nucleolus, with the initial step being the transcription of ribosomal DNA (rDNA). Although rDNA transcription is limited in somatic cells, it is more active in stem cells. Nevertheless,
Yuchen Sun +7 more
wiley +1 more source
Mesenchymal stem cell‐mediated mitochondrial transfer regulates the fate of B lymphocytes
European Journal of Clinical Investigation, EarlyView.Mesenchymal stem cells (MSCs) modulate immune responses by transferring mitochondria to immune cells, including B lymphocytes. This study demonstrates that mitochondrial transfer to CD19+ cells is linked to reactive oxygen species levels, mitophagy and activation. Mitochondria acquisition enhances B cell viability and proliferation while downregulating
Veronika Somova +8 more
wiley +1 more source
Stress‐inducible phosphoprotein 1 (Sti1/Stip1/Hop) sequesters misfolded proteins during stress
The FEBS Journal, EarlyView.Stress‐inducible phosphoprotein 1 (Sti1/Stip1/Hop) is a major co‐chaperone to both Hsp90 and Hsp70. We find that misbalanced expression of Sti1 in yeast and mammalian cells causes severe growth defects. Deletion of STI1 causes an accumulation of soluble misfolded ubiquitinated proteins and a strong activation of the heat shock response.
Benjamin S. Rutledge +7 more
wiley +1 more source
The FEBS Journal, EarlyView.We show that Mub1 links cell wall robustness with the ubiquitin‐proteasome system. As an adaptor protein of the E3 ubiquitin ligase Ubr2, it facilitates the ubiquitination of various transcription factors, including Mcm1 and Swi4. Yeasts evolved a complex regulatory programme to build and maintain their cell wall, the primary structure through which ...
Nada Šupljika +7 more
wiley +1 more source