Results 151 to 160 of about 118,231 (380)

High resolution physical mapping of single gene fragments on pachytene chromosome 4 and 7 of Rosa [PDF]

, 2015
Background: Rosaceae is a family containing many economically important fruit and ornamental species. Although fluorescence in situ hybridization (FISH)-based physical mapping of plant genomes is a valuable tool for map-based cloning, comparative ...
Khrustaleva, Ludmila I, Kirov, Ilya V, Van Laere, Katrijn   +2 more
core   +2 more sources

B cells and systemic sclerosis interstitial lung disease

Arthritis &Rheumatology, Accepted Article.
Interstitial lung disease is an important complication of systemic sclerosis (SSc‐ILD) with high mortality and morbidity. Recent clinical studies in SSc‐ILD have led to FDA‐approved therapies in SSc‐ILD. Importantly, evidence from these studies has been extrapolated to guide management of interstitial lung diseases of other systemic autoimmune ...
Nina Goldman, Voon Ong, Christopher Denton   +2 more
wiley   +1 more source

PBRM1 directs PBAF to pericentromeres and protects centromere integrity

Nature Communications
The specialised structure of the centromere is critical for effective chromosome segregation, but its repetitive nature makes it vulnerable to rearrangements.
Karen A. Lane, Alison Harrod, Lillian Wu, Theodoros I. Roumeliotis, Hugang Feng, Shane Foo, Katheryn A. G. Begg, Federica Schiavoni, Noa Amin, Frank T. Zenke, Alan A. Melcher, Jyoti S. Choudhary, Jessica A. Downs   +12 more
doaj   +1 more source

Reconstruction of the kinetochore: a prelude to meiosis

Cell Division, 2007
In eukaryotic organisms, chromosomes are spatially organized within the nucleus. Such nuclear architecture provides a physical framework for the genetic activities of chromosomes, and changes its functional organization as the cell moves through the ...
Haraguchi Tokuko, Asakawa Haruhiko, Hiraoka Yasushi   +2 more
doaj   +1 more source

Fluorescence in situ hybridisation study of micronuclei in C3A cells following exposure to ELF-magnetic fields [PDF]

, 2019
Human C3A cells were exposed to extremely low frequency (50 Hz) magnetic fields (ELF-MF's) up to 500 mu T. They were subjected to the micronucleus assay using a Fluorescence In Situ Hybridization (FISH) technique with an in-house pan-centromere probe. We
Antonissen, Roel, Baeyens, Ans, Maes, Annemarie, Verschaeve, Luc, Vral, Anne   +4 more
core   +1 more source

A randomized, placebo‐controlled trial of hydroxychloroquine in incomplete lupus

Arthritis &Rheumatology, Accepted Article.
Objectives Patients with features of systemic lupus erythematosus (SLE) who do not fulfill classification criteria can be designated as incomplete lupus (ILE). This condition includes individuals with a high risk of progression to SLE. Treatment of ILE may reduce symptoms, severity and incidence of SLE. Methods Hydroxychloroquine (HCQ) was chosen as an
Nancy J. Olsen, Duanping Liao, Judith A. James, Joel M. Guthridge, Cristina Arriens, Diane Kamen, Mariko Ishimori, Daniel J. Wallace, Christopher Striebich, Sonali Narain, Benjamin F. Chong, Fan He, Eric W. Schaefer, Vernon M. Chinchilli, David R. Karp   +14 more
wiley   +1 more source

HO Endonuclease-Initiated Recombination in Yeast Meiosis Fails To Promote Homologous Centromere Pairing and Is Not Constrained To Utilize the Dmc1 Recombinase

G3: Genes, Genomes, Genetics, 2018
Crossover recombination during meiosis is accompanied by a dramatic chromosome reorganization. In Saccharomyces cerevisiae, the onset of meiotic recombination by the Spo11 transesterase leads to stable pairwise associations between previously ...
Lina Yisehak, Amy J. MacQueen
doaj   +1 more source

Centromere evolution and CpG methylation during vertebrate speciation

Nature Communications, 2017
Centromeres and large-scale structural variants evolve and contribute to genome diversity during vertebrate speciation. Here, we perform de novo long-read genome assembly of three inbred medaka strains that are derived from geographically isolated ...
Kazuki Ichikawa, Shingo Tomioka, Yuta Suzuki, Ryohei Nakamura, K. Doi, J. Yoshimura, M. Kumagai, Yusuke Inoue, Yui Uchida, Naoki Irie, H. Takeda, S. Morishita   +11 more
semanticscholar   +1 more source

Comparative Analysis of Tandem Repeats from Hundreds of Species Reveals Unique Insights into Centromere Evolution [PDF]

, 2012
Centromeres are essential for chromosome segregation, yet their DNA sequences evolve rapidly. In most animals and plants that have been studied, centromeres contain megabase-scale arrays of tandem repeats.
Bradnam, Keith R., Chan, Simon W. -L., DeRisi, Joseph L., Eid, John, Garcia, José Fernando, Korf, Ian F., May, Michael R., Melters, Daniël P., Peluso, Paul, Rank, David, Ross-Ibarra, Jeffrey, Ruby, J. Graham, Sebra, Robert, Smith, Timothy, Telis, Natalie, Tobias, Christian, Young, Hugh A.   +16 more
core   +4 more sources

When the Clock Is Ticking: The Role of Mitotic Duration in Cell Fate Determination

BioEssays, EarlyView.
Recently, several studies identified mechanisms by which cells measure mitotic duration and how this influences cell fate, leading to normal cell cycle progression or G1 arrest. In light of drug‐resistant cancer cells that continue proliferating even after mitotic errors, understanding these mechanisms opens the door for new potential therapeutic ...
Cornelia Sala, Elmar Schiebel
wiley   +1 more source