Results 171 to 180 of about 51,411 (295)

A CRISPR‐Cas9‐based system for the dose‐dependent study of DNA double‐strand break sensing and repair

The FEBS Journal, EarlyView.
Using CRISPR‐Cas9, we engineered a genetic system allowing the dose‐dependent induction of a controllable number of DNA double‐strand breaks in Saccharomyces cerevisiae. The tool was used to study the kinetics of DNA break sensing and repair, including the spatial distribution of Tel1ATM kinase, which initiates the DNA damage response.
Morgane Auboiron, Jocelyn Coiffard, Sylvain Kumanski, Olivier Santt, Benjamin Pardo, María Moriel‐Carretero   +5 more
wiley   +1 more source

Centromeres in the thermotolerant yeast K. marxianus mediate attachment to a single microtubule. [PDF]

Chromosome Res
Barrero DJ, Hedouin S, Mao Y, Asbury CL, Stergachis AB, O'Toole E, Biggins S.   +6 more
europepmc   +1 more source

Chromatin conformation of yeast centromeres

, 1984
K.S. Bloom, E. Amaya, J. Carbon, L. Clarke, A. Hill, E. Yeh   +5 more
openalex   +2 more sources

A novel centromere monospecific serum to a human autoepitope on the histone H3‐like protein CENP‐A [PDF]

, 1998
Manuel M. Valdivia, Javier Figueroa, Concepción Iglesias, Manuela Ortı́z   +3 more
openalex   +1 more source

Multi‐omic analysis identifies biological processes underlying progressive interstitial lung disease in systemic sclerosis

The FEBS Journal, EarlyView.
Systemic sclerosis (SSc) is a rare autoimmune disease, and lung complications (ILD) are the main cause of death. This study compared SSc patients with and without lung disease to healthy volunteers. We found increased inflammation, specific proteins, and higher triglyceride levels linked to lung disease progression. These findings suggest triglycerides
Selena Bouffette, Perrine Soret, Alice Cole, Emmanuel Nony, Pierre Barbier Saint Hilaire, Grégory Leclerc, Lamine Alaoui, Audrey Aussy, Isabelle Wehrle, Aude Le Gall, Mark Coulon, Marc Pallardy, Voon Ong, Jeanne Allinne, Philippe Moingeon, David Abraham, Christopher P. Denton   +16 more
wiley   +1 more source

"End-to-End Chromosome Fusion" as the Main Driver of Descending Dysploidy in <i>Vigna lasiocarpa</i> (Mart. ex Benth.) Verdc. (Leguminosae Juss.). [PDF]

Plants (Basel)
Serafim L, Silva JH, Dias S, Oliveira ARDS, Nunes MC, da Costa AF, Benko-Iseppon AM, Jiang J, do Vale Martins L, Brasileiro-Vidal AC.   +9 more
europepmc   +1 more source

1,2-Propanediol-Induced Premature Centromere Separation in Mouse Oocytes and Aneuploidy in One-Cell Zygotes [PDF]

, 1997
John B. Mailhes, Daniel Young, Steve N. London   +2 more
openalex   +1 more source

High‐throughput screening identifies a previously undescribed checkpoint controlling mitotic progression in response to DNA damage

The FEBS Journal, EarlyView.
DNA damage can cause mitotic delay to allow DNA repair to occur. However, the mechanism underlying this is unclear. Here, we show that in response to cells entering mitosis with DNA damage, SOD1 restrains PP2a activity via oxidation of cysteine residues at the active site. This leads to a reduction in PP2a activity at the mitotic kinetochore, resulting
Nan Li, Rachel Gatenby, Thomas Walne, Caroline Daye, Steven Watson, Priya Lata, Stephen Brown, Ruth Thompson   +7 more
wiley   +1 more source

Half-tetrad analysis in zebrafish: mapping the ros mutation and the centromere of linkage group I. [PDF]

, 1995
Stephen L. Johnson, Dana Africa, Sally Horne, John H. Postlethwait   +3 more
openalex   +1 more source

Anti‐Ro52/TRIM21 autoantibodies predict Sjögren's syndrome in patients with primary biliary cholangitis

Hepatology Research, EarlyView.
Abstract Background and aims Sjögren's syndrome is a common comorbidity in patients with primary biliary cholangitis (PBC). Anti‐Ro52 autoantibodies against the protein TRIM21 are often seen in Sjögren's syndrome. TRIM21 consists of four domains (PRY/SPRY, Coiled‐Coil, B‐box, and RING domain), each with a specific function.
Marie Louise Næstholt Dahl, Trine‐Line Korsholm, Jakob Hauge Mikkelsen, Malene Hvid, Ayad Babaee, Matias Hauge Böttcher, Jesper Bach Hansen, Peter Holland‐Fischer, Christian Brix Folsted Andersen, Henning Grønbæk, Bent Deleuran   +10 more
wiley   +1 more source