Results 221 to 230 of about 118,231 (380)

A centromere’s obsession with transposons

Nature Plants
Transposable elements frequently invade centromeres, yet their influence on centromere function has long been enigmatic. A new study reveals that epigenetic silencing of centromeric transposable elements is essential for chromosome cohesion and proper segregation during cell division.
openaire   +4 more sources

Non‐canonical nitric oxide signalling and DNA methylation: Inflammation induced epigenetic alterations and potential drug targets

British Journal of Pharmacology, EarlyView.
Abstract DNA methylation controls DNA accessibility to transcription factors and other regulatory proteins, thereby affecting gene expression and hence cellular identity and function. As epigenetic modifications control the transcriptome, epigenetic dysfunction is strongly associated with pathological conditions and ageing.
Christopher H. Switzer
wiley   +1 more source

Purification of a protein binding to the CDEI subregion of Saccharomyces cerevisiae centromere DNA.

, 1989
Weidong Jiang, Peter Philippsen
openalex   +1 more source

Nuclear destabilisation – a possible genesis of cancer?

Biological Reviews, EarlyView.
ABSTRACT This review examines the increasingly prominent role of mechanics within cancer formation and progression. The extremely varied and contradictory genetic landscape of cancer is in stark contrast to the seemingly universal mechanical characteristics of cancer cells and their tumour microenvironment, and mechanics may be a principal unifying ...
Daniel D. Scott, Francesco Bettariga, Marco Ventin, Chris Bishop, Britta Stordal   +4 more
wiley   +1 more source

Canonical and Non‐Canonical Functions of Histone H3K4 Methylation Modifiers in Cancer

Cancer Science, EarlyView.
Histone H3K4‐modifying enzymes regulate gene expression and cellular processes critical to cancer development. Beyond their canonical roles, these enzymes also exhibit non‐catalytic and non‐histone functions, offering new opportunities for therapeutic intervention. ABSTRACT Histone H3K4 modifications are altered in the regulation of gene expression and
Takayuki Hoshii
wiley   +1 more source

Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by non-homologous end joining

Nature Cell Biology, 2016
P. Ly, Levi S. Teitz, D. H. Kim, Ofer Shoshani, H. Skaletsky, D. Fachinetti, D. Page, D. Cleveland   +7 more
semanticscholar   +1 more source

ACTN4 Gene Amplification and Actinin‐4 Protein Expression for Osimertinib Efficacy in EGFR‐Mutant NSCLC

Cancer Science, EarlyView.
ABSTRACT Actinin‐4 (gene name: ACTN4) is an actin‐bundling protein implicated in cancer invasion and metastasis. This study evaluated whether ACTN4 amplification and actinin‐4 protein expression were associated with osimertinib efficacy in epidermal growth factor receptor‐mutant non‐small cell lung cancer.
Takehiro Tozuka, Rintaro Noro, Yutaka Naito, Nami Miura, Shinobu Kunugi, Kazufumi Honda, Masahiro Seike   +6 more
wiley   +1 more source

Medical genetics: advances in brief: Integration of human -satellite DNA into simian chromosomes: centromere protein binding and disruption of normal chromosome segregation [PDF]

, 1992
Nalin Thakker
openalex   +1 more source

Deletion of the Mis12C‐Binding Domain of CENP‐C Promotes Chromosomal Aneuploidy in Cutaneous Squamous Cell Carcinoma

Cancer Science, EarlyView.
M12BD deficiency increases a chromosomal aneuploidy, particularly trisomy of chromosomes 6 and 10. ABSTRACT CENP‐C, an essential component of the kinetochore, connects centromeric chromatin to the outer kinetochore, and thereby ensures accurate chromosome segregation.
Megumi Saito, Kazuhiro Okumura, Yurika Tokunaga, Sora Tanaka, Keisuke Otoyama, Yoshinori Hasegawa, Masatoshi Hara, Masakazu Hashimoto, Toshihiko Fujimori, Tatsuo Fukagawa, Yuichi Wakabayashi   +10 more
wiley   +1 more source

Preserving centromere identity: right amounts of CENP-A at the right place and time. [PDF]

Chromosome Res
Pukało Z, Medina-Pritchard B, Abad MA, Jeyaprakash AA.   +3 more
europepmc   +1 more source