Results 131 to 140 of about 3,046,785 (263)

Asymmetry in centrosome maturation revealed through AIR-1 dynamics in the early Caenorhabditis elegans embryo

Scientific Reports
Centrosomes are critical organelles associated with the nucleus, consisting of a pair of centrioles surrounded by a cloud of pericentriolar material. They serve as key nucleation sites for microtubule arrays and are essential for positioning the nucleus ...
Shayne M. Plourde, Natalia Kravtsova, Adriana T. Dawes   +2 more
doaj   +1 more source

Dynamic Mitotic Localization of the Centrosomal Kinases CDK1, Plk, AurK, and Nek2 in Dictyostelium amoebae

Cells
The centrosome of the amoebozoan model Dictyostelium discoideum provides the best-established model for an acentriolar centrosome outside the Opisthokonta.
Stefan Krüger, Nathalie Pfaff, Ralph Gräf, Irene Meyer   +3 more
doaj   +1 more source

Multiwalled Carbon Nanotubes as Physical Drivers of Chromosome Instability and Inflammatory Responses

Small Structures, Volume 7, Issue 1, January 2026.
This article highlights the fibrous morphology of multiwalled carbon nanotubes as a key factor in their genotoxicity. Fibers physically interfere in cell division, generating binucleated cells and micronuclei, both of which are precursors of carcinogenesis.
Núria Pulido‐Artola, Joan Repullés, Marina Rodriguez‐Muñoz, Teresa Anglada, Anna Genescà   +4 more
wiley   +1 more source

SAS-4 is recruited to a dynamic structure in newly forming centrioles that is stabilized by the gamma-tubulin-mediated addition of centriolar microtubules. [PDF]

, 2008
Centrioles are surrounded by pericentriolar material (PCM), which is proposed to promote new centriole assembly by concentrating gamma-tubulin. Here, we quantitatively monitor new centriole assembly in living Caenorhabditis elegans embryos, focusing on ...
Dammermann, Alexander, Desai, Arshad, Maddox, Paul S, Oegema, Karen   +3 more
core   +1 more source

The Centriole Stability Assay: A Method to Investigate Mechanisms Involved in the Maintenance of the Centrosome Structure in Drosophila Cultured Cells

Bio-Protocol
Centrosomes are vital eukaryotic organelles involved in regulating cell adhesion, polarity, mobility, and microtubule (MT) spindle assembly during mitosis.
Mariana Lince-Faria, Ana Ferreira-Silva, Ana Pimenta-Marques   +2 more
doaj   +1 more source

The Proinflammatory Secretome of Senescent Cells Can Be Controlled by a HIF2A‐Dependent Upregulation and a FURIN‐Dependent Cleavage of the ANGPTL4 Secreted Factor

Aging Cell, Volume 25, Issue 1, January 2026.
This article supports that ANGPTL4 secreted factor is induced transcriptionally and activated by proteolytic cleavage during senescence, contributing to the production of a pro‐inflammatory SASP. In the senescent cell microenvironment, ANGPTL4 could thus contribute to senescence‐dependent alterations such as inflammation and tumor initiation.
Gabriela Makulyte, Hasan Safwan‐Zaiter, Delphine Goehrig, Anda Huna, Adèle Mangelinck, Takumi Mikawa, Alberta Palazzo, Lyvia Moudombi, Jean‐Jacques Medard, Marie Chanal, Pacôme Lecot, Marie‐Cécile Michallet, Julie Gavard, Serge Adnot, Pierre Dubus, Hiroshi Kondoh, Carl Mann, Nguan Soon Tan, Philippe Bertolino, Jean‐Michel Flaman, David Bernard   +20 more
wiley   +1 more source

Mitotic antipairing of homologous and sex chromosomes via spatial restriction of two haploid sets. [PDF]

, 2018
Pairing homologous chromosomes is required for recombination. However, in nonmeiotic stages it can lead to detrimental consequences, such as allelic misregulation and genome instability, and is rare in human somatic cells.
Hua, Lisa L, Mikawa, Takashi
core   +1 more source

Murine Oviductosomes (OVS) microRNA profiling during the estrous cycle: Delivery of OVS-borne microRNAs to sperm where miR-34c-5p localizes at the centrosome [PDF]

, 2018
Zeinab Fereshteh, Skye Schmidt, Amal A. Al‐Dossary, Monica Accerbi, Cecilia N. Arighi, Julie Cowart, Jia L. Song, Pamela J. Green, Kyung-Min Choi, Soonmoon Yoo, Patricia A. Martin‐DeLeon   +10 more
openalex   +1 more source

Ubiquitination dynamics in human tumour viruses: Viral infection, oncogenesis and antiviral therapy

The FEBS Journal, Volume 293, Issue 2, Page 325-347, January 2026.
The ubiquitin system is essential for cellular homeostasis and regulates many processes. Viruses, including oncogenic ones, exploit or evade this system to survive and replicate. This review explores how human tumour viruses manipulate the ubiquitination system to complete their life cycle, evade immunity and promote cancer.
Oscar Trejo‐Cerro, Martina Bergant Marušič, Justyna Broniarczyk   +2 more
wiley   +1 more source

Prolonged overexpression of PLK4 leads to formation of centriole rosette clusters that are connected via canonical centrosome linker proteins

Scientific Reports
Centrosome amplification is a hallmark of cancer and PLK4 is one of the responsible factors for cancer associated centrosome amplification. Increased PLK4 levels was also shown to contribute to generation of cells with centriole amplification in ...
Selahattin Can Ozcan, Batuhan Mert Kalkan, Enes Cicek, Ata Alpay Canbaz, Ceyda Acilan   +4 more
doaj   +1 more source