The centrosome duplication cycle in health and disease [PDF]
FEBS Letters, 2014 E. Nigg, L. Čajánek, Christian Arquint
semanticscholar +2 more sources
Centrosome Defects in Hematological Malignancies: Molecular Mechanisms and Therapeutic Insights
Blood Science, 2022 Defects in centrosomes are associated with a broad spectrum of hematological malignancies, such as leukemia and lymphoma. Centrosomes in these malignancies display both numerical and structural aberrations, including alterations in the number and size of
Mingzheng Hu, Yijie Wang, Jun Zhou
doaj +1 more source
The Identification and Functional Analysis of mRNA Localizing to Centrosomes
Frontiers in Cell and Developmental Biology, 2021 Centrosomes are multifunctional organelles tasked with organizing the microtubule cytoskeleton required for genome stability, intracellular trafficking, and ciliogenesis.
Hala Zein-Sabatto, Dorothy A. Lerit
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Unusual centrosome cycle in Dictyostelium: correlation of dynamic behavior and structural changes.
Molecular Biology of the Cell, 1999 M. Ueda, M. Schliwa, U. Euteneuer
semanticscholar +3 more sources
Global cellular response to chemical perturbation of PLK4 activity and abnormal centrosome number
eLife, 2022 Centrosomes act as the main microtubule organizing center (MTOC) in metazoans. Centrosome number is tightly regulated by limiting centriole duplication to a single round per cell cycle.
Johnny M Tkach +5 more
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Lysine demethylase 4A: from chromatin to centrosomes. [PDF]
FEBS JThe lysine demethylase 4A (KDM4A) remodels chromatin by histone demethylation, regulating gene expression. In this issue, Chowdhury et al. report a previously undescribed localisation for KDM4A outside the nucleus, at the pericentriolar material around the centrosome.
Sharma A, Kearney RM, Morrison CG.
europepmc +2 more sources
Generation and Characterization of a Tissue-Specific Centrosome Indicator Mouse Line. [PDF]
, 2016 Centrosomes are major microtubule organizing centers (MTOCs) that play an important role in chromosome segregation during cell division. Centrosomes provide a stable anchor for microtubules, constituting the centers of the spindle poles in mitotic cells,
Chen, Ju +2 more
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Centrosome Dynamics and Its Role in Inflammatory Response and Metastatic Process
Biomolecules, 2021 Metastasis is a process by which cancer cells escape from the location of the primary tumor invading normal tissues at distant organs. Chromosomal instability (CIN) is a hallmark of human cancer, associated with metastasis and therapeutic resistance. The
Massimo Pancione +6 more
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A role for Gle1, a regulator of DEAD-box RNA helicases, at centrosomes and basal bodies. [PDF]
, 2017 Control of organellar assembly and function is critical to eukaryotic homeostasis and survival. Gle1 is a highly conserved regulator of RNA-dependent DEAD-box ATPase proteins, with critical roles in both mRNA export and translation.
Akef, Abdalla +2 more
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