Results 31 to 40 of about 3,046,785 (263)

FancJ regulates interstrand crosslinker induced centrosome amplification through the activation of polo-like kinase 1

Biology Open, 2013
Summary DNA damage response (DDR) and the centrosome cycle are two of the most critical processes for maintaining a stable genome in animals. Sporadic evidence suggests a connection between these two processes.
Jianqiu Zou, Fen Tian, Ji Li, Wyatt Pickner, Molly Long, Khosrow Rezvani, Hongmin Wang, Dong Zhang   +7 more
doaj   +1 more source

The centrosome and cell proliferation

Cell Division, 2006
Centrosomes are frequently amplified in cancer cells. Increased numbers of centrosomes can give rise to multipolar spindles in mitosis, and thereby lead to the formation of aneuploid daughter cells. However, whether centrosome amplification is a cause or
Merdes Andreas, Srsen Vlastimil
doaj   +1 more source

The ciliary GTPase Arl13b regulates cell migration and cell cycle progression [PDF]

, 2016
Acknowledgments We acknowledge Prof. Tamara Caspary from Emory University for kindly providing the cell lines, Linda Duncan from the University of Aberdeen Ian Fraser Cytometry Center for help with flow cytometry.
Clancy, Hannah, Ding, Yu-Qiang, Lang, Bing, McCaig, Colin D., Pruski, Michal, Rajnicek, Ann, Yang, Zhifu   +6 more
core   +2 more sources

A mitotic kinase scaffold depleted in testicular seminomas impacts spindle orientation in germ line stem cells. [PDF]

, 2015
Correct orientation of the mitotic spindle in stem cells underlies organogenesis. Spindle abnormalities correlate with cancer progression in germ line-derived tumors.
Bucko, Paula, Canton, David, Gelman, Irwin, Hehnly, Heidi, Langeberg, Lorene K, Ogier, Leah, Santana, L Fernando, Scott, John D, Wordeman, Linda   +8 more
core   +1 more source

HTLV-1 Tax: centrosome amplification and cancer

Retrovirology, 2006
During interphase, each cell contains a single centrosome that acts as a microtubule organizing center for cellular functions in interphase and in mitosis.
Kashanchi Fatah, de la Fuente Cynthia, Pumfery Anne   +2 more
doaj   +1 more source

Co-translational protein targeting facilitates centrosomal recruitment of PCNT during centrosome maturation in vertebrates. [PDF]

, 2017
As microtubule-organizing centers of animal cells, centrosomes guide the formation of the bipolar spindle that segregates chromosomes during mitosis.
Antkowiak, Mark, Brust-Mascher, Ingrid, Castro, Noemi M, Cheung, Lee, Christensen, Lana N, Huang, Bo, Jao, Li-En, Jiang, Xueer, Mahe, Karan, Ou, Tingyoung, Sepulveda, Guadalupe, Yoon, Daniel   +11 more
core   +2 more sources

Inactivation of PLK4-STIL Module Prevents Self-Renewal and Triggers p53-Dependent Differentiation in Human Pluripotent Stem Cells

Stem Cell Reports, 2018
Summary: Centrioles account for centrosomes and cilia formation. Recently, a link between centrosomal components and human developmental disorders has been established.
Tereza Renzova, Dasa Bohaciakova, Milan Esner, Veronika Pospisilova, Tomas Barta, Ales Hampl, Lukas Cajanek   +6 more
doaj   +1 more source

Congenital microcephaly [PDF]

, 2014
The underlying etiologies of genetic congenital microcephaly are complex and multifactorial. Recently, with the exponential growth in the identification and characterization of novel genetic causes of congenital microcephaly, there has been a ...
Agha, Ahmad, Arai, Banin, Bettencourt-Dias, Bicknell, Bicknell, Bolanos-Garcia, Bond, Bongers, Buchman, Caldecott, Caldecott, Capo-Chichi, Carney, Casey, Cimprich, Cizmecioglu, Croteau, Dehay, Dehay, Deriano, Domchek, Fish, Gatz, Gellert, Genin, Gilmore, Gineau, Gorlin, Griffith, Gruber, Guernsey, Han, Hanks, Heldin, Hemerly, Herzog, Heyer, Hickson, Hinchcliffe, Hughes, Issa, Jaglin, Jamieson, Kang, Kee, Kerzendorfer, Kim, Kiyomitsu, Kiyomitsu, Koch, Kumagai, Kuo, Lancaster, Lavin, Lee, Lee, Lee, Lobrich, Loveday, Loveday, Mahmood, Maréchal, Matsumoto, Matsuoka, Matsuura, Meindl, Mimitou, Mirzaa, Miyoshi, Miyoshi, Moldovan, Morris-Rosendahl, Moshous, Moynahan, Murga, Murray, Musacchio, Mühlhans, Noguchi, Novorol, O'Driscoll, O'Driscoll, O'Driscoll, O'Driscoll, O'Driscoll, O'Driscoll, Ogi, Orii, Pilaz, Poirier, Ponting, Qvist, Rakic, Rauch, Riballo, Romaniello, Roos, Rudner, Schneider, Shah, Shaheen, Shaheen, Shamseldin, Shen, Shiloh, Sir, Sirbu, Sokka, Spalding, Spassky, Stewart, Stiff, Stokes, Symington, Tan, Thornton, van der Burg, van der Lelij, Varon, Verloes, Walczak, Waltes, Weedon, Weinfeld, Woodbine, Woods, Wu, Zimmerman   +129 more
core   +1 more source

Influence of M-phase chromatin on the anisotropy of microtubule asters [PDF]

, 1996
In many eukaryotic cells going through M-phase, a bipolar spindle is formed by microtubules nucleated from centrosomes. These microtubules, in addition to being "captured" by kinetochores, may be stabilized by chromatin in two different ways: short-range
Dogterom, M., Félix, M. A., Guet, C. C., Leibler, S.   +3 more
core   +2 more sources

Centriolin interacts with HectD1 in a cell cycle dependent manner

BMC Research Notes, 2023
Objective The centrosome is universally recognized as the microtubule organizing center of animal cells, but emerging evidence suggests that it has other important functions including primary cilia formation, DNA damage checkpoints, and cell cycle ...
Jesus Salas, Alexander Garcia, Vancy Zora, Sean Dornbush, Fady Mousa-Ibrahim, Hanna Fogg, Zeynep Gromley, Adam Gromley   +7 more
doaj   +1 more source