Results 41 to 50 of about 3,046,785 (263)

Centrosome-associated regulators of the G₂/M checkpoint as targets for cancer therapy

Molecular Cancer, 2009
In eukaryotic cells, control mechanisms have developed that restrain cell-cycle transitions in response to stress. These regulatory pathways are termed cell-cycle checkpoints.
Broaddus Russell R, Liu Jinsong, Ji Ping, Wang Yingmei, Xue Fengxia, Zhang Wei   +5 more
doaj   +1 more source

Astrin is required for the maintenance of sister chromatid cohesion and centrosome integrity [PDF]

, 2007
Faithful chromosome segregation in mitosis requires the formation of a bipolar mitotic spindle with stably attached chromosomes. Once all of the chromosomes are aligned, the connection between the sister chromatids is severed by the cysteine protease ...
Gruneberg, Ulrike, Kleylein-Sohn, Julia, Nigg, Erich A., Thein, Kerstin H.   +3 more
core   +3 more sources

Adolescent idiopathic scoliosis associated POC5 mutation impairs cell cycle, cilia length and centrosome protein interactions

PLoS ONE, 2019
Adolescent Idiopathic Scoliosis (AIS) is a spinal deformity that affects approximately 3 percent of human adolescents. Although the etiology and molecular basis of AIS is unclear, several genes such as POC5 have been identified as possible causes of the ...
Amani Hassan, S. Parent, Hélène Mathieu, C. Zaouter, Sirinart Molidperee, E. Bagu, S. Barchi, I. Villemure, S. A. Patten, F. Moldovan   +9 more
semanticscholar   +1 more source

Lysine demethylase 4A is a centrosome-associated protein required for centrosome integrity and genomic stability. [PDF]

FEBS J
KDM4A, a chromatin eraser, localizes to the centrosomes. Its demethylase activity is essential for maintaining centrosome number and integrity, independent of gene expression changes. Loss of KDM4A leads to centrosome amplification, pseudo‐bipolar spindle formation, and chromosome segregation errors, including micronuclei and chromatin bridges.
Chowdhury P, Wang X, Han RI, Motrapu M, Boice AG, Nakatani Y, Vargas-Hernandez S, Love JF, Chew C, Grimm SL, Mezquita D, Mason FM, Martinez ED, Coarfa C, Walker CL, Gustavsson AK, Dere R.   +16 more
europepmc   +2 more sources

Deterministic mechanical model of T-killer cell polarization reproduces the wandering of aim between simultaneously engaged targets [PDF]

, 2009
T-killer cells of the immune system eliminate virus-infected and tumorous cells through direct cell-cell interactions. Reorientation of the killing apparatus inside the T cell to the T-cell interface with the target cell ensures specificity of the immune
A Ashkin, A Kupfer, B Alberts, B Mickey, C Kozlowski, D Depoil, EL Botvinick, EN Cytrynbaum, F Nédélec, IA Vorobjev, IA Vorobjev, IV Maly, Ivan V. Maly, J Combs, Jason A. Papin, JM Serrador, JR Kuhn, Mun Ju Kim, S Valitutti, SW Grill, T Mitchison, T Takasone, TL Hill, W Press   +23 more
core   +7 more sources

Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling [PDF]

, 2007
Large brain size is one of the defining characteristics of modern humans. Seckel syndrome (MIM 210600), a disorder of markedly reduced brain and body size, is associated with defective ATR-dependent DNA damage signaling.
A Kramer, A Purohit, Anand Saggar, Andrew P Jackson, Ben Hamel, Bertrand Vernay, C Ponting, Carol-Anne Martin, CG Woods, D Chen, D Diviani, Elen Griffith, F Majewski, F Ruschendorf, GK Alderton, GK Alderton, H Dodson, H Loffler, H Niida, HPG Seckel, J Bond, J Bond, JB Dictenberg, K Miyoshi, M Martinez-Campos, M O'Driscoll, Mark O'Driscoll, MR Flory, Nouriya Al Sanna, P Brown, Paola Vagnarelli, Penny A Jeggo, Q Li, RD Martin, S Doxsey, S Sengupta, S Zhang, Sarah Walker, SJ Doxsey, Tom Stiff, WC Zimmerman, William C Earnshaw, Y Shiloh   +42 more
core   +4 more sources

New insights into subcomplex assembly and modifications of centrosomal proteins

Cell Division, 2012
This review provides a brief overview of the recent work on centrosome proteomics, protein complex identification and functional characterization with an emphasis on the literature of the last three years.
Habermann Karin, Lange Bodo MH
doaj   +1 more source

A Proximity Mapping Journey into the Biology of the Mammalian Centrosome/Cilium Complex

Cells, 2020
The mammalian centrosome/cilium complex is composed of the centrosome, the primary cilium and the centriolar satellites, which together regulate cell polarity, signaling, proliferation and motility in cells and thereby development and homeostasis in ...
Melis Dilara Arslanhan, Dila Gulensoy, Elif Nur Firat-Karalar   +2 more
doaj   +1 more source

TgCep250 is dynamically processed through the division cycle and is essential for structural integrity of the Toxoplasma centrosome

bioRxiv, 2018
The Toxoplasma centrosome is a unique bipartite structure comprising an inner- and outer-core responsible for the nuclear cycle (mitosis) and budding cycles (cytokinesis), respectively.
Chun‐Ti Chen, Marc-Jan Gubbels
semanticscholar   +1 more source

The Microcephaly-Associated Protein Wdr62/CG7337 Is Required to Maintain Centrosome Asymmetry in Drosophila Neuroblasts

Cell Reports, 2016
Summary: Centrosome asymmetry has been implicated in stem cell fate maintenance in both flies and vertebrates, but the underlying molecular mechanisms are incompletely understood.
Anjana Ramdas Nair, Priyanka Singh, David Salvador Garcia, David Rodriguez-Crespo, Boris Egger, Clemens Cabernard   +5 more
doaj   +1 more source