Results 51 to 60 of about 3,046,785 (263)

Polo-like kinase 4 controls centriole duplication but does not directly regulate cytokinesis. [PDF]

, 2012
Centrioles organize the centrosome, and accurate control of their number is critical for the maintenance of genomic integrity. Centrioles duplicate once per cell cycle, and duplication is coordinated by Polo-like kinase 4 (Plk4).
Bettencourt-Dias, Monica, Chen, Denaly, Cleveland, Don W, Da Cruz, Sandrine, Fachinetti, Daniele, Holland, Andrew J, Lince-Faria, Mariana, Parish, Nicole, Verma, Inder M, Vitre, Benjamin, Zhu, Quan   +10 more
core   +4 more sources

Truncation of POC1A associated with short stature and extreme insulin resistance [PDF]

, 2015
We describe a female proband with primordial dwarfism, skeletal dysplasia, facial dysmorphism, extreme dyslipidaemic insulin resistance and fatty liver associated with a novel homozygous frameshift mutation in POC1A, predicted to affect two of the three ...
Adams, Claire, Barrett, Jeff, Barroso, Inês, Chen, Jian Hua, Durbin, Richard, Farooqi, Sadaf, Fitzpatrick, David, Geschwind, Daniel, Huang Doran, Isabel, Hurles, Matt, Kaye, Jane, Keane, Thomas, Kennedy, Karen, Langford, Cordelia, Mccarthy, Shane, Muddyman, Dawn, Owen, Michael, O’Rahilly, Stephen, Palotie, Aarno, Payne, Felicity, Richards, Bren, Savage, David B., SEGNI, Maria, Semple, Robert K., Sleigh, Alison, Soranzo, Nicole, Spector, Tim, Stalker, Jim, Timpson, Nic, Zeggini, Eleftheria   +29 more
core   +3 more sources

Regulation of the cell cycle and centrosome biology by deubiquitylases

Biochemical Society Transactions, 2017
Post-translational modification of proteins by ubiquitylation is increasingly recognised as a highly complex code that contributes to the regulation of diverse cellular processes.
S. Darling, A. Fielding, Dorota Sabat-Pośpiech, I. Prior, J. Coulson   +4 more
semanticscholar   +1 more source

Protocol to measure inter-centrosome distance in adherent cells using epifluorescence microscopy

STAR Protocols, 2022
Summary: We present here a protocol to assay the centrosome separation events at late-G2 phase of the cell cycle by immunofluorescence microscopy. We describe the steps required for imaging and measurement of inter-centrosome distance.
Franco K.C. Au, Edna S.W. Lui, Robert Z. Qi   +2 more
doaj   +1 more source

Casein kinase II is required for proper cell division and acts as a negative regulator of centrosome duplication in Caenorhabditis elegans embryos

Biology Open, 2017
Centrosomes are the primary microtubule-organizing centers that orchestrate microtubule dynamics during the cell cycle. The correct number of centrosomes is pivotal for establishing bipolar mitotic spindles that ensure accurate segregation of chromosomes.
Jeffrey C. Medley, Megan M. Kabara, Michael D. Stubenvoll, Lauren E. DeMeyer, Mi Hye Song   +4 more
doaj   +1 more source

Interaction of CK1δ with γTuSC ensures proper microtubule assembly and spindle positioning. [PDF]

, 2015
Casein kinase 1δ (CK1δ) family members associate with microtubule-organizing centers (MTOCs) from yeast to humans, but their mitotic roles and targets have yet to be identified.
Agard, David A, Barnes, Georjana, Drubin, David G, Giddings, Thomas H, Han, Xuemei, Kollman, Justin, Lyon, Andrew, Moritz, Michelle, Peng, Yutian, Winey, Mark, Yates, John   +10 more
core   +1 more source

53BP1 and USP28 mediate p53-dependent cell cycle arrest in response to centrosome loss and prolonged mitosis

eLife, 2016
Mitosis occurs efficiently, but when it is disturbed or delayed, p53-dependent cell death or senescence is often triggered after mitotic exit. To characterize this process, we conducted CRISPR-mediated loss-of-function screens using a cell-based assay in
C. S. Fong, Gregory Mazo, T. Das, Joshua Goodman, Minhee Kim, brian P. o’rourke, Denisse Izquierdo, M. B. Tsou   +7 more
semanticscholar   +1 more source

Ccdc11 is a novel centriolar satellite protein essential for ciliogenesis and establishment of left-right asymmetry [PDF]

, 2016
The establishment of left–right (L-R) asymmetry in vertebrates is dependent on the sensory and motile functions of cilia during embryogenesis. Mutations in CCDC11 disrupt L-R asymmetry and cause congenital heart disease in humans, yet the molecular and ...
Betleja, Ewelina, John, Emily, Mahjoub, Moe R, Mitchell, Brian J, Moresco, James J, Silva, Erica, Spear, Philip, Yates, John R, III, Zhang, Siwei   +8 more
core   +2 more sources

Centrosome and retroviruses: The dangerous liaisons

Retrovirology, 2007
Centrosomes are the major microtubule organizing structures in vertebrate cells. They localize in close proximity to the nucleus for the duration of interphase and play major roles in numerous cell functions.
Mahieux Renaud, Saïb Ali, Zamborlini Alessia, Afonso Philippe V   +3 more
doaj   +1 more source

The centrosomal deubiquitylase USP21 regulates Gli1 transcriptional activity and stability [PDF]

, 2016
USP21 is a centrosome-associated deubiquitylase (DUB) that has been implicated in the formation of primary cilia - crucial organelles for the regulation of the Hedgehog (Hh) signaling pathway in vertebrates. Here, we identify KCTD6 - a cullin-3 E3-ligase
Bertsoulaki, Erithelgi, Clague, Michael J., Cucchi, Danilo, DE SMAELE, Enrico, Heride, Claire, Rigden, Daniel J., Urbé, Sylvie   +6 more
core   +1 more source