Results 31 to 40 of about 2,276 (229)

Discovery of KV1.3 ion channel inhibitors: Medicinal chemistry approaches and challenges

Medicinal Research Reviews, Volume 41, Issue 4, Page 2423-2473, July 2021., 2021
Abstract The KV1.3 voltage‐gated potassium ion channel is involved in many physiological processes both at the plasma membrane and in the mitochondria, chiefly in the immune and nervous systems. Therapeutic targeting KV1.3 with specific peptides and small molecule inhibitors shows great potential for treating cancers and autoimmune diseases, such as ...
Špela Gubič, Louise A. Hendrickx, Žan Toplak, Maša Sterle, Steve Peigneur, Tihomir Tomašič, Luis A. Pardo, Jan Tytgat, Anamarija Zega, Lucija P. Mašič   +9 more
wiley   +1 more source

Sex‐Biased Gene Expression of Mesobuthus martensii Collected from Gansu Province, China, Reveals Their Different Therapeutic Potentials

Evidence-Based Complementary and Alternative Medicine, Volume 2021, Issue 1, 2021., 2021
The scorpions, named Mesobuthus martensii, commonly called Quanxie (全蝎) in Chinese, have been widely used as one of the animal medicines for more than 1,000 years because of the strong toxicity of their venoms. Meanwhile, scorpions are sexually dimorphic in appearance, and many exhibit traits associated with sex‐biased gene expression, including ...
Songyu Gao, Feng Wu, Xintong Chen, Ying Yang, Yina Zhu, Liang Xiao, Jing Shang, Xiaowei Bao, Yi Luo, Haihu Chen, Qing Liu, Oluwafemi Adeleke Ojo   +11 more
wiley   +1 more source

Study of the Acute Toxicity of Scorpion Leiurus macroctenus Venom in Rats. [PDF]

ScientificWorldJournal
Background. The expansion of the territory of human habitation leads to inevitable interference in the natural range of distribution of one or another species of animals, some of which may be dangerous for human life. Scorpions—the Arachnida class and order Scorpiones—can be considered as such typical representatives.
Gunas V, Maievskyi O, Raksha N, Vovk T, Savchuk O, Shchypanskyi S, Gunas I.   +6 more
europepmc   +2 more sources

Taking the sting out of scorpions: Electrophysiological investigation of the relative efficacy of three antivenoms against medically significant Centruroides species

Comparative biochemistry and physiology. Toxicology & pharmacology : CBP
Sam I. D. Campbell, Chun Yuen Chow, Édgar Neri-Castro, Alejandro Alagón, Aarón Gómez, Raúl Soria, Glenn F. King, Bryan G. Fry   +7 more
openalex   +2 more sources

Cardiovascular effects of the scorpions Centruroides margaritatus, Centruroides limpidus and Centruroides noxius crude venom

The FASEB Journal, 2019
Scorpions from the Centruroides genus have high toxicity and it is potentially dangerous to humans. In this study we compare the effect of the crude venom of a colombiam scorpion Centruroides margaritatus ( Cm ...
Cláudia Ferreira Santos, Jessica Dayana Galíndez Céron, Alexandre Havt Bindá, Lourival D Possani, José Béltran Vidal, Manassés Claudino Fonteles, Nilberto Robson Falcão Nascimento   +6 more
openaire   +1 more source

Evidencias morfológicas y moleculares que validan como especie a Centruroides tecomanus (Scorpiones, Buthidae)

Revista Mexicana de Biodiversidad, 2009
SE PRESENTAN EVIDENCIAS MORFOLÓGICAS Y MOLECULARES PARA RECONOCER A CENTRUROIDES LIMPIDUS TECOMANUS HOFFMANN (SCORPIONES: BUTHIDAE) COMO ESPECIE VÁLIDA Y NO COMO UNA SUBESPECIE DE CENTRUROIDES LIMPIDUS (KARSCH). SE DIAGNOSTICA LA ESPECIE.
ÓSCAR F. FRANCKE B., JAVIER PONCE SAAVEDRA, ERASTO HERNÁNDEZ CALDERÓN, HORACIO CANO CAMACHO   +3 more
doaj   +1 more source

Envenomation by Centruroides pococki scorpion with neuromuscular toxicity

Toxicon, 2020
Cases of human envenomation by Centruroides pococki are exceptionally reported in human. We report a Class III human envenomation by C. pococki in Guadeloupe, French West Indies, with neuromuscular toxicity that has never been described before. Symptoms resolved within a few hours, without the need for intravenous scorpion-specific antivenom.
Weniko Caré, Sébastien Larréché, Paul Busser, Laurène Dufayet, Dominique Vodovar, Luc de Haro, Jérôme Langrand   +6 more
openalex   +5 more sources

Descripción de una especie nueva de alacrán con importancia médica del género Centruroides (Scorpiones: Buthidae) del estado de Colima, México

Revista Mexicana de Biodiversidad, 2009
Se describe Centruroides hirsutipalpus sp. nov. de la región de Minatitlán, Colima. Se compara con las especies morfológica y geográficamente más cercanas, C. elegans Thorell y C.
Javier Ponce-Saavedra, Oscar F. Francke
doaj   +1 more source

A robust genome and assembly with transcriptomic data from the striped scorpion, Centruroides vittatus

bioRxiv, 2023
Scorpions, a seemingly primitive, stinging arthropod taxa, are known to exhibit marked diversity in their venom components. These venoms are known for their human pathology, but also important as models for therapeutic and drug development applications ...
T. Yamashita, D. Rhoads, Jeff Pummill
semanticscholar   +1 more source

Scorpion venom and its adaptive role against pathogens: a case study in Centruroides granosus Thorell, 1876 and Escherichia coli

Frontiers in Arachnid Science, 2023
Scorpion venoms have been studied extensively, mostly aimed at applications for human health, with strong evidence of antimicrobial properties. However, ecological studies on the adaptive role of these antimicrobial properties have been mostly neglected.
Dumas Gálvez, Eleodoro Bonilla, Carlos Vega   +2 more
semanticscholar   +1 more source