Results 111 to 120 of about 223 (124)

Pharmacokinetics of the toxic fraction of Centruroides limpidus limpidus venom in experimentally envenomed rabbits and effects of immunotherapy with specific F(ab′)2

Toxicon, 1999
Envenomations after scorpion stings are a major health problem throughout the world. Their specific treatment is immunotherapy which consists of the injection of specific antibody. In this article, we studied the pharmacokinetics of the toxic fraction of Centruroides limpidus limpidus venom (fraction II) in experimentally envenomed rabbits.
E S, Calderón-Aranda, G, Rivière, V, Choumet, L D, Possani, C, Bon   +4 more
openaire   +2 more sources

Isolation of several toxins from the venom of the scorpion Centruroides limpidus tecomanus Hoffmann

Toxicon, 1988
The soluble venom of the scorpion of Colima, Mexico, was fractionated by Sephadex G-50 gel filtration followed by separation of the toxic fraction (number II) with carboxymethyl-cellulose columns in 20 mM ammonium acetate buffer, pH 4.7. Of 24 fractions five were toxic to mice and were further separated in 50 mM phosphate buffer, pH 6.0 using the same ...
A N, Ramírez, G B, Gurrola, B M, Martin, L D, Possani   +3 more
openaire   +2 more sources

Venom content and toxicity regeneration after venom gland depletion by electrostimulation in the scorpion Centruroides limpidus

Toxicon, 2019
The scorpion venom is a cocktail of many components. Its composition can exhibit a level of plasticity in response to different behavioral and environmental factors, leading to intraspecific variation. The toxicity and specificity of scorpion venoms appear to be taxon-dependent, due to a co-evolutionary interaction with prey and predators, which shaped
Edson Norberto Carcamo-Noriega, Lourival Domingos Possani, Ernesto Ortiz   +2 more
openaire   +2 more sources

Functional and immuno-reactive characterization of a previously undescribed peptide from the venom of the scorpion Centruroides limpidus

Peptides, 2017
A previously undescribed toxic peptide named Cl13 was purified from the venom of the Mexican scorpion Centruroides limpidus. It contains 66 amino acid residues, including four disulfide bonds. The physiological effects assayed in 7 different subtypes of voltage gated Na+-channels, showed that it belongs to the β-scorpion toxin type.
Timoteo, Olamendi-Portugal, Rita, Restano-Cassulini, Lidia, Riaño-Umbarila, Baltazar, Becerril, Lourival D, Possani   +4 more
openaire   +2 more sources

Comparative proteomic analysis of female and male venoms from the Mexican scorpion Centruroides limpidus: Novel components found

Toxicon, 2017
Venom from male and female scorpions of the species Centruroides limpidus were separated by HPLC and their molecular masses determined by mass spectrometry. The relative concentration of components eluting in equivalent retention times from the HPLC column shows some differences.
Jimena Isaias Cid Uribe, Juana Maria Jiménez Vargas, Cesar Vicente Ferreira Batista, Fernando Zamudio Zuñiga, Lourival Domingos Possani   +4 more
openaire   +2 more sources

Venom components of the scorpion Centruroides limpidus modulate cytokine expression by T helper lymphocytes: Identification of ion channel-related toxins by mass spectrometry

International Immunopharmacology, 2020
The study of the effector mechanisms of T helper cells has revealed different phenotypic characteristics that can be manipulated for designing new therapeutic schemes in different pathological scenarios. Ion channels are significant targets in T lymphocyte modulation since they are closely related to their effector activity.
Julián M, Cota-Arce, Daniela, Zazueta-Favela, Fernando, Díaz-Castillo, Samanta, Jiménez, Johanna, Bernáldez-Sarabia, Nadia L, Caram-Salas, Kee W L, Dan, Galileo, Escobedo, Alexei F, Licea-Navarro, Lourival D, Possani, Marco A, De León-Nava   +10 more
openaire   +2 more sources

Experimental envenoming of mice with venom from the scorpion Centruroides limpidus limpidus: differences in mortality and symptoms with and without antibody therapy relating to differences in age, sex and strain of mouse

Toxicon, 2003
C57Bl/6J and BALB/cAnN inbred strains of mice differed significantly in mortality and symptoms when intoxicated subcutaneously with one LD(50) of venom from Centruroides limpidus limpidus. Higher mortality was observed in C57Bl/6J than in BALB/cAnN. Also, C57Bl/6J mice more quickly developed muscular and respiratory collapse whilst BALB/cAnN mice were ...
Alejandro, Padilla, Tzipe, Govezensky, Lourival D, Possani, Carlos, Larralde   +3 more
openaire   +2 more sources

Immunity against the venom of Mexican scorpion Centruroides lumpidus limpidus induced by some proteins from this venom.

Annales d'immunologie, 1980
A protein fraction, which consisted of at least 12 proteins, was obtained from the venom of Mexican scorpion Centruroides limpidus limpidus. The molecular weights of these proteins ranged between 9,800 and 163,000 daltons. This fraction was separated from the rest of the venom components, which were almost all neurotoxins, by chromatographying the ...
J L, Molinari, P, Tato Zaldivar, L, Méndez   +2 more
openaire   +1 more source

Dissecting Toxicity: The Venom Gland Transcriptome and the Venom Proteome of the Highly Venomous Scorpion Centruroides limpidus (Karsch, 1879)

Toxins, 2019
Jimena I Cid-Uribe, Cesar V F Batista, Ernesto Ortiz   +2 more
exaly  

[Radiation with gamma-rays of scorpions of the species Centruroides limpidus].

Revista del Instituto de Salubridad y Enfermedades Tropicales, 1998
L, MAZZOTTI, R H, RHODE, F, LOPEZ, J, TELICH   +3 more
openaire   +1 more source