Results 11 to 20 of about 2,263 (197)
Small Molecule Inhibitors of Ceramidases [PDF]
Cellular Physiology and Biochemistry, 2014 The equilibrium between the pro-apoptotic ceramide and pro-vital sphingosine-1-phosphate is considered to be decisive for cell death or survival.
Essa M. Saied, Christoph Arenz
doaj +3 more sources
Frontiers in Plant Science, 2015 Ceramidases hydrolyze ceramide into sphingosine and fatty acids and, although ceramidases function as key regulators of sphingolipid homeostasis in mammals, their roles in plants remain largely unknown.
Nan Yao
exaly +3 more sources
Probing compartment-specific sphingolipids with targeted bacterial sphingomyelinases and ceramidases
Journal of Lipid Research, 2019 Sphingolipids contribute to the regulation of cell and tissue homeostasis, and disorders of sphingolipid metabolism lead to diseases such as inflammation, stroke, diabetes, and cancer.
Daniel Canals +2 more
exaly +3 more sources
Acid ceramidase regulates innate immune memory [PDF]
Cell Reports, 2023 Innate immune memory, also called "trained immunity," is a functional state of myeloid cells enabling enhanced immune responses. This phenomenon is important for host defense, but also plays a role in various immune-mediated conditions. We show that exogenously administered sphingolipids and inhibition of sphingolipid metabolizing enzymes modulate ...
Nils Rother +24 more
openaire +6 more sources
Dysbiosis in the Pathogenesis of Atopic Dermatitis. [PDF]
J DermatolABSTRACT Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by epidermal barrier dysfunction and immune dysregulation. Recent research highlights cutaneous dysbiosis as a critical factor in its pathogenesis. In this review, we summarize the interplay between the skin microbiota and host immunity, contrasting the homeostatic ...
Okamoto H, Nakamura Y.
europepmc +2 more sources
Targeting Acid Ceramidase Inhibits Glioblastoma Cell Migration through Decreased AKT Signaling
Cells, 2022 Glioblastoma (GBM) remains one of the most aggressive cancers, partially due to its ability to migrate into the surrounding brain. The sphingolipid balance, or the balance between ceramides and sphingosine-1-phosphate, contributes to the ability of GBM ...
Cyntanna C. Hawkins +12 more
doaj +1 more source
The Dark Side of Sphingolipids: Searching for Potential Cardiovascular Biomarkers
Biomolecules, 2023 Cardiovascular diseases (CVDs) are the leading cause of death and illness in Europe and worldwide, responsible for a staggering 47% of deaths in Europe.
Paola Di Pietro +10 more
doaj +1 more source
Metabolites involved in cellular communication among human cumulus-oocyte-complex and sperm during in vitro fertilization [PDF]
, 2015 Background: Fertilization is a key physiological process for the preservation of the species. Consequently, different mechanisms affecting the sperm and the oocyte have been developed to ensure a successful fertilization. Thus, sperm acrosome reaction is
Avilés Sánchez, Manuel +11 more
core +6 more sources
CREST - a large and diverse superfamily of putative transmembrane hydrolases
Biology Direct, 2011 Background A number of membrane-spanning proteins possess enzymatic activity and catalyze important reactions involving proteins, lipids or other substrates located within or near lipid bilayers. Alkaline ceramidases are seven-transmembrane proteins that
Olson Eric N +3 more
doaj +1 more source
Sphingolipids as emerging mediators in retina degeneration [PDF]
, 2019 The sphingolipids ceramide (Cer), sphingosine-1-phosphate (S1P), sphingosine (Sph), and ceramide-1-phosphate (C1P) are key signaling molecules that regulate major cellular functions.
Prado Spalm, Facundo Heber +3 more
core +1 more source