Results 41 to 50 of about 2,263 (197)

Functions of neutral ceramidase in the Golgi apparatus

Journal of Lipid Research, 2018
Ceramidases hydrolyze ceramides into sphingosine and fatty acids, with sphingosine being further metabolized into sphingosine-1-phosphate (S1P); thus, ceramidases control the levels of these bioactive sphingolipids in cells and tissues.
Wataru Sakamoto, Nicolas Coant, Daniel Canals, Lina M. Obeid, Yusuf A. Hannun   +4 more
doaj   +1 more source

Sebaceous-immunobiology is orchestrated by sebum lipids [PDF]

, 2018
K
Lovászi, Marianna, Szegedi, Andrea, Töröcsik, Dániel, Zouboulis, Christos C.   +3 more
core   +1 more source

Increased dihydroceramide/ceramide ratio mediated by defective expression of degs1 impairs adipocyte differentiation and function. [PDF]

, 2014
Adipose tissue dysfunction is an important determinant of obesity-associated, lipid-induced metabolic complications. Ceramides are well-known mediators of lipid-induced insulin resistance in peripheral organs such as muscle.
Barbarroja, Nuria, Camargo, Antonio, Cuadrado, Irene, Lopez-Pedrera, Chary, Medina-Gomez, Gema, Nygren, Heli, Oresic, Matej, Pellegrinelli, Vanessa, Pirraco, Ana, Relat, Joana, Rodriguez-Cuenca, Sergio, Summers, Scott A, Symons, J David, Tinahones, Francisco J, Vidal-Puig, Antonio   +14 more
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Catalytic Mechanism of Eukaryotic Neutral Ceramidase [PDF]

Structure, 2015
Neutral ceramidases are key enzymes of sphingolipid metabolism that hydrolyze the fatty acyl/sphingosine amide linkage of ceramide at neutral pH. In this issue of Structure, Airola et al. (2015) present the first crystal structure of human nCDase and show how complexation with phosphate supports a new catalytic mechanism for Zn-dependent amidases while
Malinina, Lucy, Brown, Rhoderick E.
openaire   +2 more sources

Low serum sphingolipids in children with attention deficit-hyperactivity disorder [PDF]

, 2015
Background: Attention deficit-hyperactivity disorder (ADHD) is the most prevalent neuropsychiatric condition in childhood. ADHD is a multifactorial trait with a strong genetic component. One neurodevelopmental hypothesis is that ADHD is associated with a
Benjamin I Kim, Marcela Patricia Henríquez-Henríquez, Marcela Patricia Henríquez-Henríquez, Richard J. Deckelbaum, Sandra eSolari, Teresa eQuiroga, Tilla S. Worgall   +6 more
core   +2 more sources

Sphingosine kinase 1 in breast cancer: A new molecular marker and a therapy target [PDF]

, 2020
It is now well-established that sphingosine kinase 1 (SK1) plays a significant role in breast cancer development, progression, and spread, whereas SK1 knockdown can reverse these processes.
Alshaker, Heba, Pchejetski, Dmitri, Thrower, Hannah   +2 more
core   +1 more source

Myocardium of type 2 diabetic and obese patients is characterized by alterations in sphingolipid metabolic enzymes but not by accumulation of ceramide[S]

Journal of Lipid Research, 2010
Data from animal experiments strongly suggest that ceramide is an important mediator of lipotoxicity in the heart and that accumulation of ceramide contributes to cardiomyocyte apoptosis associated with type 2 diabetes and obesity.
Marcin Baranowski, Agnieszka Blachnio-Zabielska, Tomasz Hirnle, Dorota Harasiuk, Krzysztof Matlak, Malgorzata Knapp, Piotr Zabielski, Jan Gorski   +7 more
doaj   +1 more source

Inhibition of ceramide accumulation in AdipoR1–/– mice increases photoreceptor survival and improves vision

JCI Insight, 2022
Adiponectin receptor 1 (ADIPOR1) is a lipid and glucose metabolism regulator that possesses intrinsic ceramidase activity. Mutations of the ADIPOR1 gene have been associated with nonsyndromic and syndromic retinitis pigmentosa.
Dominik Lewandowski, Andrzej T. Foik, Roman Smidak, Elliot H. Choi, Jianye Zhang, Thanh Hoang, Aleksander Tworak, Susie Suh, Henri Leinonen, Zhiqian Dong, Antonio F.M. Pinto, Emily Tom, Jennings Luu, Joan Lee, Xiuli Ma, Erhard Bieberich, Seth Blackshaw, Alan Saghatelian, David C. Lyon, Dorota Skowronska-Krawczyk, Marcin Tabaka, Krzysztof Palczewski   +21 more
doaj   +1 more source

Lipids under stress - a lipidomic approach for the study of mood disorders [PDF]

, 2015
The emerging field of lipidomics has identified lipids as key players in disease physiology. Their physicochemical diversity allows precise control of cell structure and signaling events through modulation of membrane prop- erties and trafficking of ...
Antonny, Arevalo, Bazinet, Bessa, Björkhem, Bligh, Bozek, Brügger, Buchenauer, Catania, Cermenati, Cerqueira, Cerruti, Chan, Chang, Choi, Chuang, Dawson, De Kroon, Delisi, Di Paolo, Di Paolo, Dias, Dias-Ferreira, Dietschy, Dunkley, Fahy, Fahy, Feder, Giovacchini, Green, Green, Guan, Gulbins, Han, Hannun, Hartmann, Heverin, Holthuis, Holthuis, Huang, Karran, Kassas, Kay, Kielkowska, Kim, Kloda, Klose, Kodigepalli, Kornhuber, Lam, Lamaziere, Lee, Lev, Levant, Little, Liu, Lupien, Lütjohann, Maceyka, Malcher-Lopes, Mapstone, McMahon, McNamara, Mesmin, Miller, Morel, Mouritsen, Movahed, Müller, Nestler, Nestler, Nguyen, Nicolson, Oliveira, Oliveira, Oliveira, Ortolani, Pinto, Piomelli, Popoli, Prasad, Prasad, Puri, Radhakrishnan, Ricart-Jané, Roozendaal, Sanchez, Sanchez-Mejia, Schauder, Schultz, Shevchenko, Simons, Simons, Sousa, Sousa, Sousa, Sousa, Subramanian, Sundaram, Takamori, Thatcher, Tiemeier, Van Meer, Vetrivel, Wakelam, Walter, Wenk, Wenk, Williamson, Wymann, Yang, Zhang, Zhang, Zolov   +114 more
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Ceramidase Regulates Synaptic Vesicle Exocytosis and Trafficking [PDF]

The Journal of Neuroscience, 2004
A screen forDrosophilasynaptic dysfunction mutants identifiedslug-a-bed(slab). Theslabgene encodes ceramidase, a central enzyme in sphingolipid metabolism and regulation. Sphingolipids are major constituents of lipid rafts, membrane domains with roles in vesicle trafficking, and signaling pathways. Nullslabmutants arrest as fully developed embryos with
Jeffrey, Rohrbough, Emma, Rushton, Laura, Palanker, Elvin, Woodruff, Heinrich J G, Matthies, Usha, Acharya, Jairaj K, Acharya, Kendal, Broadie   +7 more
openaire   +2 more sources