Results 61 to 70 of about 2,263 (197)

Phase II Trial of Opaganib Addition in Metastatic Castration‐Resistant Prostate Cancer After Disease Progression on Abiraterone or Enzalutamide

Cancer Medicine, Volume 15, Issue 4, April 2026.
This phase II trial investigated the safety and efficacy of opaganib in combination with abiraterone or enzalutamide in patients with castration‐resistant prostate cancer (CRPC). While the study did not meet its disease control efficacy endpoint, there was evidence of clinical activity in a subset of patients.
Jacqueline T. Brown, Bassel Nazha, Anna C. Ferreira, Kent Armeson, Elizabeth G. Hill, Besim Ogretmen, Shikhar Mehrotra, Alan Brisendine, George Magrath, Terry F. Plasse, Theodore Stewart Gourdin, Omer Kucuk, Michael Lilly   +12 more
wiley   +1 more source

Genetics of gene expression characterizes response to selective breeding for alcohol preference [PDF]

, 2014
Numerous selective breeding experiments have been performed with rodents, in an attempt to understand the genetic basis for innate differences in preference for alcohol consumption.
Flink, S., Grahame, N. J., Hoffman, P. L., Kechris, K., Saba, L. M., Tabakoff, B.   +5 more
core   +1 more source

Membrane topology of yeast alkaline ceramidase YPC1 [PDF]

Biochemical Journal, 2013
Ypc1p (yeast phyto-ceramidase 1) and Ydc1p (yeast dihydroceramidase 1) are alkaline ceramide hydrolases that reside in the ER (endoplasmic reticulum). Ypc1p can catalyse the reverse reaction, i.e. the condensation of non-esterified fatty acids with phytosphingosine or dihydrosphingosine and overexpression of YPC1 or YDC1 can provide enough ceramide ...
Ramachandra, Nagaraju, Conzelmann, Andreas   +1 more
openaire   +2 more sources

The crystal structure of human transport and Golgi organization 2 homolog (TANGO2) suggests a cysteine N‐terminal nucleophile (Ntn) hydrolase

Acta Crystallographica Section D, Volume 82, Issue 4, Page 383-396, April 2026.
This study reports the first crystal structure of human TANGO2, mutations of which are responsible for TANGO2 deficiency disorder. The crystallographic analysis demonstrates that interactions between heme and TANGO2 are nonspecific, helping to address ongoing questions about the role of TANGO2 as a heme‐trafficking protein.Recently, there has been ...
Dayong Zhou, Lirong Chen, John Rose, Bi-Cheng Wang   +3 more
wiley   +1 more source

ORMDL Proteins Turnover via Proteasome and Autophagy Is Cell‐Type Dependent and Tied to Ceramide Homeostasis

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
ORMDL proteins in the endoplasmic reticulum (ER) negatively regulate serine palmitoyltransferase (SPT) activity in response to the rate of de novo sphingolipid synthesis. Disruption of ceramide homeostasis by myriocin or fumonisin B1 (FB1) appears to destabilize the ORMDL‐SPT complex, leading to ORMDL degradation as a feedback mechanism.
Michal Mrkacek, Magda Tumova, Alex Puskasu, Pavol Utekal, Marek Vrbacky, Ladislav Kuchar, Petr Draber, Viktor Bugajev   +7 more
wiley   +1 more source

Adiponectin inhibits tumor necrosis factor-α-induced vascular inflammatory response via caveolin-mediated ceramidase recruitment and activation. [PDF]

, 2014
RATIONALE: Anti-inflammatory and vascular protective actions of adiponectin are well recognized. However, many fundamental questions remain unanswered.
Booth, David, Gao, Erhe, Koch, Walter, Lau, Wayne Bond, Li, Jing-Jing, Ma, Xin-Liang, Preston, Kyle, Scalia, Rosario, Wang, Xiaoliang, Wang, Yajing, Yuan, Yuexing   +10 more
core   +2 more sources

Improved synthesis of a fluorogenic ceramidase substrate [PDF]

Bioorganic & Medicinal Chemistry, 2010
Substantial interest has focused on the roles of sphingolipid metabolizing enzymes in a variety of hyperproliferative and inflammatory diseases. A key family of enzymes involved in these pathologies is the ceramidases. Ceramidases cleave the pro-apoptotic lipid ceramide into a long-chain fatty acid and sphingosine, which can then be further metabolized
Xia, Zuping, Draper, Jeremiah M, Smith, Charles D   +2 more
openaire   +3 more sources

F13A1‐Mediated Macrophage Activation Promotes MASH Progression via the PKM2/HIF1A Pathway

Advanced Science, Volume 13, Issue 13, 3 March 2026.
In fatty liver disease, hepatocytes exposed to palmitate release S1P, which activates calcium signaling in macrophages. Elevated calcium enhances the activity of F13A1, driving PKM2 dimerization. The PKM2 dimers cause Warburg effect, translocate to the nucleus, cooperate with HIF1A, and upregulate IL1B expression, ultimately promoting classical ...
Qianrang Lu, Meiching Ong, Xuewen Yi, Muqiong Xing, Xinyao Tian, Ke Zhang, Ling Lu, Hao Wang, Xiaohan Lin, Jun Fang, Aibo Mu, Jiaying Cao, Jingyu Jiang, Feng Gao, Hongjun Li, Baohong Wang, Qi Ling   +16 more
wiley   +1 more source

Intracellular proton pumps as targets in chemotherapy: V-ATPases and cancer [PDF]

, 2012
Cancer cells show a metabolic shift that makes them overproduce protons; this has the potential to disturb the cellular acid-base homeostasis. However, these cells show cytoplasmic alkalinisation, increased acid
Hernández López, Agustín, Pérez Castiñeira, José Román, Serrano Bueno, Gloria, Serrano Delgado, Aurelio   +3 more
core   +1 more source

Degradation of hexosylceramides is required for timely corpse clearance via formation of cargo-containing phagolysosomal vesicles

European Journal of Cell Biology
Efficient degradation of phagocytic cargo in lysosomes is crucial to maintain cellular homeostasis and defending cells against pathogens. However, the mechanisms underlying the degradation and recycling of macromolecular cargo within the phagolysosome ...
Rebecca Holzapfel, Agata Prell, Fabian Schumacher, Veronika Perschin, José Pedro Friedmann Angeli, Burkhard Kleuser, Christian Stigloher, Gholamreza Fazeli   +7 more
doaj   +1 more source