Results 71 to 80 of about 2,263 (197)

Hyperthyroidism Evokes Myocardial Ceramide Accumulation

Cellular Physiology and Biochemistry, 2015
Background: Thyroid hormones (THs) are key regulators of cardiac physiology as well as modulators of different cellular signals including the sphingomyelin/ceramide pathway.
Agnieszka Mikłosz, Bartłomiej Łukaszuk, Adrian Chabowski, Filip Rogowski, Krzysztof Kurek, Małgorzata Żendzian-Piotrowska   +5 more
doaj   +1 more source

Text mining of full-text journal articles combined with gene expression analysis reveals a relationship between sphingosine-1-phosphate and invasiveness of a glioblastoma cell line [PDF]

, 2006
Background Sphingosine 1-phosphate (S1P), a lysophospholipid, is involved in various cellular processes such as migration, proliferation, and survival. To date, the impact of S1P on human glioblastoma is not fully understood. Particularly, the concerted
Berrar, Daniel, Bremer, Eric G., DeSesa, Catherine, Dubitzky, Werner, Hack, Catherine, Natarajan, Jeyakumar, Van Brocklyn, James R., Zhang, Yonghong   +7 more
core   +5 more sources

A Systemic Selective Modified mRNA Delivery Platform for Preventing Chemotherapy‐Induced Cardiotoxicity

Advanced Science, Volume 13, Issue 10, 18 February 2026.
In Yoo and Mainkar et al., we present a minimally invasive, CM‐selective modRNA delivery system encapsulated in lipid nanoparticles for intravenous (IV) administration. This platform enables selective cardiac translation of therapeutic modRNA but suppresses expression in off‐target tissues, including tumors.
Jimeen Yoo, Gayatri Mainkar, Matteo Ghiringhelli, Bernardo Gindri Dos Santos, Magdalena M. Żak, Keerat Kaur, Ann Anu Kurian, Matthew Adjmi, Segev Sharon, Eftychia Markopoulou, Lucia Žigová, Daniela Hirsch, Sydney Pessin, Rachel Hanan, Juan Luis Escano Abreu, Niki Brisnovali, Nicole Dubois, Leigh Goedeke, Mengcheng Shen, Lior Zangi   +19 more
wiley   +1 more source

Feeding a Modified Fish Diet to Bottlenose Dolphins Leads to an Increase in Serum Adiponectin and Sphingolipids.

Frontiers in Endocrinology, 2016
Feeding a modified fish diet has been suggested to improve insulin sensitivity in bottlenose dolphins; however insulin sensitivity was not directly measured.
Philip Michael Sobolesky, Tyler S Harrell, Celeste eParry, Stephanie eVenn-Watson, Michael Gregory Janech, Michael Gregory Janech   +5 more
doaj   +1 more source

Secreted Proteases from Dermatophytes [PDF]

, 2018
Dermatophytes are highly specialized pathogenic fungi that exclusively infect the stratum corneum, nails or hair, and it is evident that secreted proteolytic activity is important for their virulence.
Monod, Michel
core  

Therapeutic potential of targeting sphingosine kinases and sphingosine 1-phosphate in hematological malignancies [PDF]

, 2016
Sphingolipids, such as ceramide, sphingosine and sphingosine 1-phosphate (S1P) are bioactive molecules that have important functions in a variety of cellular processes, which include proliferation, survival, differentiation and cellular responses to ...
Barata, J T, Buontempo, F, Chiarini, F, Evangelisti, C, Evangelisti, C, Lonetti, A, Martelli, A M, Orsini, E, Pyne, N J, Pyne, S   +9 more
core   +1 more source

The Reverse Activity of Human Acid Ceramidase [PDF]

Journal of Biological Chemistry, 2003
An overexpression system was recently developed to produce and purify recombinant, human acid ceramidase. In addition to ceramide hydrolysis, the purified enzyme was able to catalyze ceramide synthesis using [14C]lauric acid and sphingosine as substrates.
Nozomu, Okino, Xingxuan, He, Shimon, Gatt, Konrad, Sandhoff, Makoto, Ito, Edward H, Schuchman   +5 more
openaire   +2 more sources

Disrupting Lipid Raft Microdomains to Block Polyploid Giant Cancer Cell Budding and Enhance Radiotherapy Response

Advanced Science, Volume 13, Issue 9, 13 February 2026.
Radiation induces polyploid giant cancer cells (PGCCs) that regenerate tumors through virus‐like budding. This process depends on a SNCG–FLOT2–CHMP4B signaling axis functioning in lipid raft microdomains. Disrupting these domains using statins or anti‐PCSK9 antibodies blocks PGCC budding, suppresses tumor repopulation, and enhances radiotherapy ...
Zheng Deng, Haoran Sun, Jin Cheng, Ruyi Zhao, Jianzhu Xie, Yanwei Song, Yucui Zhao, Chenwei Lin, Binjie Hu, Yanping Gong, Jun Lin, Sijia He, Yuntao Luo, Minghui Zhao, Yiwei Wang, Ming Jiao, Yuqin Yang, Jikun Li, Shujie Xia, Chuanyuan Li, Qian Huang   +20 more
wiley   +1 more source

Myomaker and ether lipids cooperate to promote fusion-competent membrane states

Cell Reports
Summary: Cell fusion is a fundamental process for skeletal muscle development and regeneration. The muscle-specific fusogens Myomaker and Myomerger are necessary for fusion of muscle cells and together are sufficient for fusion.
Tanner J. Wherley, Xueheng Zhao, Sajedah M. Hindi, Laura J.S. Lopes, Evgenia Leikina, Fiona C. Rowan, Kenneth D.R. Setchell, Alexander J. Sodt, Leonid V. Chernomordik, Douglas P. Millay   +9 more
doaj   +1 more source

Lipidomic Analysis of Plasma Extracellular Vesicles from Adiponectin Deficient Mice or Metabolic Syndrome Patients Reveals Pro‐Oxidative and Pro‐Inflammatory Lipid Signatures Correlating with Metabolic Dysfunction

Journal of Extracellular Vesicles, Volume 15, Issue 2, February 2026.
Adiponectin deficiency remodels the lipid composition of plasma extracellular vesicles (EV), enriching polyunsaturated phospholipids and reducing lysophospholipids. These remodelled EV impact oxidative, inflammatory and metabolic function in recipient cells.
Sungji Cho, Hye Kyoung Sung, Khang Nguyen, Yubin Lei, Sivaporn Wannaiampikul, Brian Lee, Eddie Tam, Yihan Luo, Evgeniy V. Petrotchenko, Christoph H. Borchers, Kacey J. Prentice, Scott A Summers, Dylan Burger, Gary Sweeney   +13 more
wiley   +1 more source