Results 91 to 100 of about 2,263 (197)
Communications BiologyTwo mammalian homologs of systemic RNA interference defective protein 1 (SID-1) (SIDT1/2) are suggested to function as double-stranded RNA (dsRNA) transporters for extracellular dsRNA uptake or for release of incorporated dsRNA from lysosome to cytoplasm.
Yoshinori Hirano +5 more
doaj +1 more source
Brain Pathology, Volume 36, Issue 1, January 2026.Sphingolipids are vital components of cell membranes. Metabolic disruptions of sphingolipids, including ceramide and sphingosine‐1‐phosphate, are linked to neurological disorders. This article summarizes the classification, structure, and metabolic processes of sphingolipids, and the physiological and pathological effects of sphingolipid metabolism and
Tian Li +7 more
wiley +1 more source
Topical Live and Heat‐Killed Probiotics for Photoaging Prevention: A Meta‐Analysis
Dermatology Research and Practice, Volume 2026, Issue 1, 2026.Background The skin microbiome plays a crucial role in maintaining healthy skin, and imbalances in this microbial community, often caused by aging and environmental factors like UV radiation, are linked to photoaging. Topical probiotics may help prevent it.
Marina Rimadhani +5 more
wiley +1 more source
Restoring the Sphingolipid Balance in Glioblastoma [PDF]
, 2022 Glioblastoma (GBM) is a highly aggressive brain tumor with a median survival of 15 months even with standard of care—surgical resection, radiotherapy, and chemotherapy.
Hawkins, Cyntanna C
core +1 more source
Phylogenetic Analysis of Neutral Ceramidase
International Journal of Computer Applications, 2014 ceramidase (NCDase) plays an important role in cell regulation, and has been observed in most of the organism across different groups. In this study the molecular evolution of NCDase in different organisms was studied. The phylogenetic tree relationships among the organisms were explored by comparing the sequences of their NCDase.
Rufus Auxillia, Nirmal Rajah.R
openaire +1 more source
Role of neutral ceramidase in colon cancer
The FASEB Journal, 2016 ABSTRACT Alterations in sphingolipid metabolism, especially ceramide and sphingosine 1‐phosphate, have been linked to colon cancer, suggesting that enzymes of sphingolipid metabolism may emerge as novel regulators and targets in colon cancer.
Mónica, García-Barros +13 more
openaire +3 more sources
CDase is a pan-ceramidase inDrosophila
Molecular Biology of the Cell, 2011 Ceramidases catalyze the conversion of ceramide to sphingosine. They are acylaminohydrolases that catalyze the deacylation of the amide-linked saturated fatty acid from ceramide to generate sphingosine. They also catalyze the reverse reaction of ceramide biosynthesis using sphingosine and fatty acid.
Yuan, Changqing +9 more
openaire +3 more sources
Acid ceramidase confers radioresistance to glioblastoma cells
Oncology Reports, 2017 Glioblastoma multiforme (GBM) is the most common primary, intracranial malignancy of the central nervous system. The standard treatment protocol, which involves surgical resection, and concurrent radiation with adjuvant temozolomide (TMZ), still imparts a grim prognosis.
Doan, Ninh B. +9 more
openaire +3 more sources
Handling a Novel Nanoscale D-erythro-MAPP in Lung Cancer Treatment: An In vitro Cytotoxicity Research [PDF]
, 2020 Cancer disease cause high mortality rates through the world. Lung cancer has ranked between the most prevalent cancers among the rare cancer types. Surgical resection, chemotherapy and radiation are current techniques for its treatment.
Kutlu, Hatice Mehtap +2 more
core +1 more source