Results 261 to 270 of about 110,293 (352)

Lifespan‐Extending Endogenous Metabolites

Aging Cell, Volume 25, Issue 2, February 2026.
Endogenous metabolites act as mediators of longevity by modulating conserved cellular pathways. We summarize mechanistic evidence linking specific metabolites to lifespan and healthspan benefits across model systems, with discussion of clinical evidence, translational opportunities, and remaining knowledge gaps.
Yizhou Jiang, Jing‐Dong J. Han
wiley   +1 more source

Acyl‐CoA Binding Protein in White and Brown Adipose Tissue Is Dispensable for Systemic Energy Metabolism in Mice

Acta Physiologica, Volume 242, Issue 2, February 2026.
ABSTRACT Aim Acyl‐CoA binding protein plays a vital role in lipid metabolism by mediating the intracellular flux and utilization of long‐chain acyl‐CoAs. We generated an adipocyte‐wide ACBP knockout mouse and a brown adipose tissue‐specific ACBP knockout mouse to investigate ACBP function in adipose tissue.
M. F. Nørremark, R. Petersen, P. M. M. Ruppert, E. S. Jul, T. K. Doktor, R. Nielsen, J. F. Kappel, S. Larsen, J. W. Kornfeld, S. Mandrup, B. S. Andresen, J. Havelund, D. Neess, N. J. Færgeman   +13 more
wiley   +1 more source

Evogliptin prevents ceramide-induced pyroptosis during calcification via modulation of NLRP3/GSDM-D mediated pathway in Vascular Smooth Muscle Cells. [PDF]

PLoS One
Rahil RR, Shamas S, Wani NA, Nanda N, Ahmad SF, Attia SM, Hamid A, Zargar MA, Bhat OM.   +8 more
europepmc   +1 more source

Suppression of endothelial ceramide de novo biosynthesis by Nogo-B contributes to cardiometabolic diseases [PDF]

Luisa Rubinelli, Onorina L. Manzo, Sungho Jin, Ilaria Del Gaudio, Rohan Bareja, Alice Marino, Sailesh Palikhe, Vittoria Di Mauro, Mariarosaria Bucci, Domenick J. Falcone, Olivier Elemento, Baran A. Ersoy, Sabrina Diano, Linda Sasset, Annarita Di Lorenzo   +14 more
openalex   +1 more source

MSC‐Derived Secretome and Exosomes in Dermatology: Mechanisms, Therapeutic Opportunities, and Scientific Challenges—A Narrative Review

International Journal of Dermatology, Volume 65, Issue 2, Page 257-272, February 2026.
ABSTRACT Mesenchymal stromal cells (MSCs) exert their effects primarily through paracrine signaling via soluble factors and extracellular vesicles (EVs), especially exosomes. These acellular components offer regenerative and immunomodulatory benefits with fewer safety and logistical constraints than cell‐based therapies.
Marcela da Costa Pereira Cestari, Reinaldo Falavigna Tovo, Daniela Franco Bueno   +2 more
wiley   +1 more source

Rare skin disease helps uncover mechanisms of acyl ceramide biosynthesis. [PDF]

J Lipid Res
Tollinger S, Ortner D, Trafoier T, Moosbrugger-Martinz V, Gruber R, Schmuth M.   +5 more
europepmc   +1 more source

A comprehensive measure of Golgi sphingolipid flux using NBD C6-ceramide: evaluation of sphingolipid inhibitors [PDF]

Allen H. Lee, Justin M. Snider, Sitapriya Moorthi, Nicolas Coant, Magali Trayssac, Daniel Canals, Christopher J. Clarke, Chiara Luberto, Yusuf A. Hannun   +8 more
openalex   +1 more source

Effect of a Spray Containing Occlusive Agents, Humectants and Physiological Lipids on Skin Hydration of Healthy Dogs When Applied After Bathing With a Chlorhexidine 2%/Miconazole 2% Shampoo

Veterinary Dermatology, Volume 37, Issue 1, Page 140-147, February 2026.
Background: Normal hydration of the canine epidermis is imperative for cutaneous homeostasis. Xerosis may be encountered in canine atopic dermatitis and may be aggravated by topical antiseptics. Hypothesis and Objectives: To evaluate the hydrating properties and the safety of a spray (Sensiderm spray; MP Labo) when applied after shampooing healthy dogs
Adamantia Pseftogka, Elisabeta Samuel (Badulescu), Manolis K. Chatzis, Manolis N. Saridomichelakis   +3 more
wiley   +1 more source

Heterogeneity of common carotid artery and abdominal aorta: an angle of sphingolipid metabolism in vascular smooth muscle cells. [PDF]

Biomed Eng Online
Li B, Zhou K, Chen K, Jiang S, Wang X, Gu Z, Gu C, Han Y, Liu Y, Chang Y, Bao J.   +10 more
europepmc   +1 more source