Cell Proliferation, EarlyView.The pathogenic mechanisms of pulmonary vascular endothelial cells (VECs) in lung diseases and their multimodal therapeutic strategies. ABSTRACT Pulmonary vascular endothelial cells (VECs) are essential for the normal function of the lung, through maintaining vascular barrier integrity, regulating blood flow, and participating in inflammatory responses ...
Qianyue Liu +5 more
wiley +1 more source
Lifespan-Extending Endogenous Metabolites. [PDF]
Aging CellEndogenous metabolites act as mediators of longevity by modulating conserved cellular pathways. We summarize mechanistic evidence linking specific metabolites to lifespan and healthspan benefits across model systems, with discussion of clinical evidence, translational opportunities, and remaining knowledge gaps.
Jiang Y, Han JJ.
europepmc +2 more sources
Therapeutic potential of targeting ceramide for early cardiometabolic lipotoxicity in vivo study [PDF]
Youssef M. Shalaby +5 more
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CFTR Clustering and Tethering in Ceramide-Platforms in Response to Post-Infection PKC Stimulation [PDF]
, 2014 Asmahan Abu‐Arish +3 more
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p75NTR Promotes Circadian‐Driven Mineralization During Tooth Development via CK2/PER2 Pathway
Cell Proliferation, EarlyView.The diagram illustrates how the circadian rhythm regulates the p75NTR‐CK2‐PER2 axis, driving rhythmic biomineralisation during tooth development. ABSTRACT Circadian rhythm is an essential biological process that synchronises physiological activities with environmental light/dark cycles.
Manzhu Zhao +8 more
wiley +1 more source
Reversing the effects of ceramide imbalance via anti-ceramide immunotherapy is an effective therapy for diabetic retinopathy. [PDF]
Cell Death DiscovZhou L, Li J, Fu C, Chu WK.
europepmc +1 more source
Diabetes, Obesity and Metabolism, EarlyView.Abstract Metabolic and bariatric surgery (MBS) is the most effective treatment for severe obesity. It usually results in spectacular weight loss, associated with improvements of obesity‐associated comorbidities. The mechanisms underlying these benefits are not fully understood but could involve a postoperative activation of the enzyme 5′ AMP‐activated ...
Adrien Delcour, Nathalie Niederhoffer
wiley +1 more source
Heterogeneity of common carotid artery and abdominal aorta: an angle of sphingolipid metabolism in vascular smooth muscle cells. [PDF]
Biomed Eng OnlineLi B +10 more
europepmc +1 more source
Ceramide induces p38 MAPK and JNK activation through a mechanism involving a thioredoxin-interacting protein-mediated pathway [PDF]
, 2008 Chia‐Ling Chen +5 more
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Sensing of cardiolipin exposure on plasma membranes of apoptotic cells by EryA‐mCherry protein
The FEBS Journal, EarlyView.An aegerolysin protein erylysin A (EryA) fused with mCherry binds to artificial lipid vesicles supplemented with cardiolipin (CL). This binding is much more specific than that of annexin V, which binds various negatively charged glycerophospholipids (PG, PS, PI). In mammalian cells, the CL exposition at the membrane surface represents an early hallmark
Luka Žeželj +12 more
wiley +1 more source