Results 241 to 250 of about 33,232 (287)

Skeletal muscle insulin resistance in prediabetes: a lipidomic perspective on diacylglycerols, ceramides, and phospholipids. [PDF]

Sci Rep
Markova I, Hüttl M, Šťastný J, Zapletalova I, Kačer P, Hönig V, Kacerova T, Malinska H.   +7 more
europepmc   +1 more source

Tks4‐Targeted Gene Therapy Inhibited White Adipocyte Hypertrophy in Mice

The FASEB Journal, Volume 40, Issue 2, 31 January 2026.
Tks4 knockout or knockdown by AAV mediated shRNA both successfully restricted adipocyte hypertrophy in high fat diet. The reduction of TAG was validated by biochemistry and lipidomics analyses. This study suggested a potential of Tks4 targeted therapy in obesity intervention. ABSTRACT Obesity is one of the most prevalent public health issues worldwide,
Meng Tian, Jingwen Deng, Yuzhu Hong, Ruitong Liu, Shengnan Li, Xiaoxiao He   +5 more
wiley   +1 more source

Novel Strategies against Hepatocellular Carcinoma through Lipid Metabolism. [PDF]

Oncol Res
Yang Y, Zhao P, Chen H, Tu Y, Zhou Y, Liu X, Sreang L, Zhou Z, Tu J.   +8 more
europepmc   +1 more source

Evaluating the Efficacy of Soothing Agents in Mitigating 0.1% Retinol-Induced Skin Irritation: A Patch Test. [PDF]

J Cosmet Dermatol
Ying Y, Fang Y, Chenlan X, Lin S, Jiefang H, Yanan L, Peiwen S.   +6 more
europepmc   +1 more source

Simultaneous Grafting of 3,4,5‐Trihydroxypiperidine Iminosugars Onto Multivalent Scaffolds via Double Reductive Amination Provides New GCase Inhibitors

Chemistry – A European Journal, Volume 32, Issue 2, 9 January 2026.
A small set of low‐valency multivalent 3,4,5‐trihydroxypiperidines was prepared through double reductive amination (DRA) of a sugar‐derived dialdehyde. Among them, trivalent derivative 37 emerged as a potent β‐glucocerebrosidase (GCase) inhibitor displaying an unexpected mixed‐type kinetic profile. The integration of kinetic analysis, NMR, docking, and
Maria Giulia Davighi, Francesca Clemente, Alessio Morano, Francesca Mangiavacchi, Francesca Cardona, Andrea Goti, Paolo Paoli, Amelia Morrone, Ferran Nieto‐Fabregat, Roberta Marchetti, Camilla Matassini   +10 more
wiley   +1 more source

Metabolomics Analysis Uncovers Distinct Profiles of Liver Post-Transplant Patients by Immunosuppression Regimen. [PDF]

Metabolites
Baciu C, Hasjim BJ, Maleki S, Pasini E, Patel MK, Shojaee M, Azhie A, Saracino G, Asrani SK, Bhat M.   +9 more
europepmc   +1 more source

Body Biofluids for Minimally‐Invasive Diagnostics: Insights, Challenges, Emerging Technologies, and Clinical Potential

Advanced Healthcare Materials, Volume 15, Issue 4, 26 January 2026.
Recent advances in diagnostics have accelerated the development of miniaturized wearable technologies for the continuous monitoring of diseases. This paradigm is shifting healthcare away from invasive, centralized blood tests toward decentralized monitoring, using alternative body biofluids.
Lanka Tata Rao, Chandan Kumar Mandal, Fernando Patolsky   +2 more
wiley   +1 more source

Sugar accelerates chronological aging in yeast via ceramides. [PDF]

Cell Stress
Schmiedhofer V, Sommersguter-Wagner J, Knittelfelder O, Jungwirth H, Rechberger GN, Carmona-Gutierrez D, Rockenfeller P, Ruckenstuhl C, Madeo F.   +8 more
europepmc   +1 more source

Retraction: Overexpressed PKCδ Downregulates the Expression of PKCα in B16F10 Melanoma: Induction of Apoptosis by PKCδ via Ceramide Generation

The PLOS One Editors
openalex   +2 more sources

Increased Unsaturation of Fatty Acids in Covalently Bound Ceramides Is Linked to Disordered Intercellular Lipid Structure and Skin Hypersensitivity. [PDF]

J Cosmet Dermatol
Kawamoto A, Joichi T, Katsukura H, Zhai L, Watanabe D, Yamamoto N, Haneoka M, Nakamura S, Nakazawa H, Yoshida H.   +9 more
europepmc   +1 more source