Results 71 to 80 of about 42,785 (261)

Connecting the dots: A narrative review of the relationship between heart failure and cognitive impairment

ESC Heart Failure, Volume 12, Issue 2, Page 1119-1131, April 2025.
Abstract Large clinical data underscore that heart failure is independently associated to an increased risk of negative cognitive outcome and dementia. Emerging evidence suggests that cerebral hypoperfusion, stemming from reduced cardiac output and vascular pathology, may contribute to the largely overlapping vascular dementia and Alzheimer's disease ...
Mauro Massussi, Maria Giulia Bellicini, Marianna Adamo, Andrea Pilotto, Marco Metra, Alessandro Padovani, Riccardo Proietti   +6 more
wiley   +1 more source

Correlating familial Alzheimer’s disease gene mutations with clinical phenotype [PDF]

, 2010
Alzheimer’s disease (AD) causes devastating cognitive impairment and an intense research effort is currently devoted to developing improved treatments for it.
Rossor, M.N., Ryan, N.S.
core   +1 more source

Spontaneous ARIA (Amyloid-Related Imaging Abnormalities) and Cerebral Amyloid Angiopathy Related Inflammation in Presenilin 1-Associated Familial Alzheimer's Disease [PDF]

, 2015
Amyloid-related imaging abnormalities (ARIA), thought to reflect immune responses to vascular amyloid, have been detected in several amyloid-modifying therapy trials for Alzheimer's disease (AD).
Dantu, K, Fox, NC, Lashley, T, Morris, HR, Revesz, T, Ryan, NS   +5 more
core   +1 more source

A1 reactive astrocytes and a loss of TREM2 are associated with an early stage of pathology in a mouse model of cerebral amyloid angiopathy

Journal of Neuroinflammation, 2020
Background Cerebral amyloid angiopathy (CAA) is typified by the cerebrovascular deposition of amyloid. The mechanisms underlying the contribution of CAA to neurodegeneration are not currently understood.
Xavier Taylor, Pablo Cisternas, Y. You, Yin-jun You, S. Xiang, Yamil Marambio, Jie Zhang, R. Vidal, Cristian A. Lasagna-Reeves   +8 more
semanticscholar   +1 more source

Coupling CZE, Liquid‐Phase Ion Mobility, to MS/MS for Quantitative Top‐Down Proteomics: Revealing Significant Proteoform Differences Between Healthy and Alzheimer's Disease Brains

PROTEOMICS, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive decline and pathological protein aggregation. Comprehensive quantitative proteomics of brain tissues from AD patients is critical for pursuing a better understanding of the molecular mechanisms that drive AD progression.
Mehrdad Falamarzi Askarani, Fei Fang, Scott E. Counts, Liangliang Sun   +3 more
wiley   +1 more source

Dense-core senile plaques in the Flemish variant of Alzheimer's disease are vasocentric [PDF]

, 2002
Alzheimer's disease (AD) is characterized by deposition of beta-amyloid (Abeta) in diffuse and senile plaques, and variably in vessels. Mutations in the Abeta-encoding region of the amyloid precursor protein (APP) gene are frequently associated with very
Broeckhoven, C. (Christine) van, Ceuterick, C., Cras, P. (Patrick), Duijn, C.M. (Cornelia) van, Kros, J.M. (Johan), Kumar-Singh, S. (Samir), Lubke, U., Marck, E.A. (Eric) van, Martin, J-J. (Jean-Jacques), Serneels, S. (Sally), Swieten, J.C. (John) van, Timmermans, J.P., Vennekens, K., Wang, R. (Rong)   +13 more
core   +1 more source

Emerging concepts in sporadic cerebral amyloid angiopathy.

Brain : a journal of neurology, 2017
Sporadic cerebral amyloid angiopathy is a common, well-defined small vessel disease and a largely untreatable cause of intracerebral haemorrhage and contributor to age-related cognitive decline.
A. Charidimou, G. Boulouis, M. Gurol, C. Ayata, B. Bacskai, M. Frosch, A. Viswanathan, S. Greenberg   +7 more
semanticscholar   +1 more source

Migrasomes, Matrix‐Bound Nanovesicles, and More: Messengers in the Matrix

PROTEOMICS, EarlyView.
ABSTRACT Extracellular vesicles (EVs) and particles (EPs) are diverse micro‐ and nanoparticles that circulate in bodily fluids and can attach to, or be deposited onto, the extracellular matrix (ECM) and other surfaces. To date, the nomenclature and classification of matrix‐bound or matrix‐associated EVs and EPs (MEVPs) have been unclear, largely due to
Anna V. Kolesov, Natalie Reitz, Marley Dewey, Colin L. Hisey   +3 more
wiley   +1 more source

Cerebral amyloid angiopathy revealed by severe renal failure: A case report

Radiology Case Reports
Sporadic cerebral amyloid angiopathy is a common condition in the elderly, characterised by the accumulation of amyloid Aβ peptide in the walls of small cerebral arteries, leading to intracranial haemorrhage and cognitive impairment.
El Ouazzani Mouad, Bouchoual Mohammed, Boughmi Amine, Bounabe Rabia, Bigi Soufiane, Anibar Sara, Jabrane Marouane, Wakrim Soukaina, Arrayhani Mohamed   +8 more
doaj   +1 more source

Cerebral Microbleeds in a Stroke Prevention Clinic. [PDF]

, 2019
The objective of this study is to assess the effectiveness of a stroke clinic in stroke prevention and progression of cerebral microbleeds (CMB). We conducted a retrospective observational study of patients who visited a stroke clinic between January ...
Chang, Peter, Cho, A-Hyun, Chow, Daniel, Fisher, Mark, Floriolli, David, Paganini-Hill, Annlia, Shah, Krunal, Wadi, Lara   +7 more
core   +1 more source