Results 61 to 70 of about 1,594,854 (292)

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Evaluation of a novel PET tracer [18F]-Florbetazine for Alzheimer's disease diagnosis and β-amyloid deposition quantification

NeuroImage
[18F]-Florbetazine ([18F]-92) is a selective PET tracer for β-amyloid (Aβ) depositions with a novel diaryl-azine scaffold to reduce lipophilicity and to achieve higher gray-to-white matter contrast.
Meiqi Wu, Chao Ren, Chenhui Mao, Liling Dong, Bo Li, Xueqian Yang, Zhenghai Huang, Haiqiong Zhang, Yuying Li, Mengshi Yan, Qi Ge, Runze Wu, Feng Feng, Mengchao Cui, Jing Gao, Li Huo   +15 more
doaj   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Change in the central control of the bladder function of rats with focal cerebral infarction induced by photochemically-induced thrombosis.

PLoS ONE, 2021
The photochemically-induced thrombosis (photothrombosis) method can create focal cerebral infarcts anywhere in the relatively superficial layers of the cerebrum; it is easy to implement and minimally invasive.
Yuya Ota, Yasue Kubota, Yuji Hotta, Mami Matsumoto, Nayuka Matsuyama, Taiki Kato, Takashi Hamakawa, Tomoya Kataoka, Kazunori Kimura, Kazunobu Sawamoto, Takahiro Yasui   +10 more
doaj   +1 more source

Common Blood Flow Changes across Visual Tasks: II. Decreases in Cerebral Cortex

Journal of Cognitive Neuroscience, 1997
Nine previous positron emission tomography (PET) studies of human visual information processing were reanalyzed to determine the consistency across experiments of blood flow decreases during active tasks relative to passive viewing of the same stimulus ...
G. Shulman, J. Fiez, M. Corbetta, R. Buckner, F. Miezin, M. Raichle, S. Petersen   +6 more
semanticscholar   +1 more source

Structure–Function Decoupling of the Sensorimotor and Default Mode Networks in Black Americans With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B‐PwMS) experience a more severe disease course than non‐Hispanic White people with MS (NHW‐PwMS). Here we investigated structural and functional connectivity as well as structure–function decoupling in the ...
Emilio Cipriano, Giacomo Boffa, Maria Petracca, Marta Ponzano, Nicole Graziano, Claire Wigley, Claire Riley, Jonathan Howard, Pietro Bontempi, Sylvia Klineova, Fred Lublin, Matilde Inglese   +11 more
wiley   +1 more source

Biomaterial-engineering and neurobiological approaches for regenerating the injured cerebral cortex

Regenerative Therapy, 2016
The cerebral cortex is responsible for higher functions of the central nervous system (CNS), such as movement, sensation, and cognition. When the cerebral cortex is severely injured, these functions are irreversibly impaired.
Itsuki Ajioka
doaj   +1 more source

Baseline Regional Cholinergic Denervation Predicts Cognitive Trajectories in Moderate Parkinson Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive decline is a disabling and variable feature of Parkinson disease (PD). While cholinergic system degeneration is linked to cognitive impairments in PD, most prior research reported cross‐sectional associations. We aimed to fill this gap by investigating whether baseline regional cerebral vesicular acetylcholine transporter ...
Taylor Brown, Giulia Carli, Prabesh Kanel, Stiven Roytman, Jaimie Barr, Nicolaas I. Bohnen, Roger L. Albin   +6 more
wiley   +1 more source

FEATURES OF NEUROENERGYMETABOLISM AND ACTIVATION INFLUENCES ON CEREBRAL CORTEX IN CHILDREN OF PRIMARY SHOOL AGE WITH DIFFERENT TYPES OF TEMPERAMENT AND SUCCESS IN LEARNING

В мире научных открытий, 2017
The aim of the study was to identify the relationship with intensity of energy metabolism and the level of activation of the cerebral cortex in primary schoolchildren with different temperament characteristic and their possible influence on successful ...
Natalya Sergeevna Bedereva, Sergey Nikolaevich Shilov, Irina Akimovna Ignatova   +2 more
doaj   +1 more source

Conditioned reflexes: An investigation of the physiological activity of the cerebral cortex

Annals of Neurosciences, 2010
The development of the objective method in investigating the physiological activities of the cerebral hemispheres. – Concept of Reflex. -- Variety of Reflexes. -- Signal reflexes, the most fundamental physiological characteristic of the hemispheres. doi :
I. Pavlov
semanticscholar   +1 more source