Results 61 to 70 of about 1,638,797 (414)

Cerebral blood flow and behavioural effects of caffeine in habitual and non-habitual consumers of caffeine: A near infrared spectroscopy study [PDF]

, 2011
Caffeine has been shown to modulate cerebral blood flow, with little evidence of tolerance to these effects following habitual use. However, previous studies have focused on caffeine levels much higher than those found in dietary servings and have ...
Adan, Addicott, Addicott, Ahlemeyer, Alexopoulos, Alsene, Attwood, Brice, Brice, Cameron, Chen, Chen, Childs, Cornelis, Crystal F. Haskell, Dager, David O. Kennedy, de Mendonca, Drummond, Durlach, Farag, Field, Fredholm, Gray, Green, Haskell, Haskell, Heatherley, Heatherley, Hettema, Hewlett, Hoshi, Huppert, James, James, Johansson, Jones, Kazui, Kendler, Kennedy, Kennedy, Kennedy, Kennedy, Keppel, Koppelstaetter, Laurienti, Laurienti, Lawrence, Li, Lovallo, Luciano, Lunt, Mathew, Mulderink, Obrig, Perthen, Quinlan, Reay, Reay, Richardson, Riksen, Riksen, Rogers, Schroeter, Shi, Sigmon, Smit, Smith, Smith, Steinbrink, Title, Umemura, Varani, Varani, Varani, Warburton, Widlansky, Yeomans   +77 more
core   +1 more source

Soman induces endoplasmic reticulum stress and apoptosis of cerebral organoids via the GRP78‐ATF6‐CHOP signaling pathway

FEBS Open Bio, EarlyView.
Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei, Zhanbiao Liu, Jingjing Shi, Qian Jin, Wenqian Chen, Xuejun Chen, Liqin Li, Hui Chen   +7 more
wiley   +1 more source

Increased glutamate receptor and transporter expression in the cerebral cortex and striatum of gcdh-/- mice: possible implications for the neuropathology of glutaric acidemia type I.

PLoS ONE, 2014
We determined mRNA expression of the ionotropic glutamate receptors NMDA (NR1, NR2A and NR2B subunits), AMPA (GluR2 subunit) and kainate (GluR6 subunit), as well as of the glutamate transporters GLAST and GLT1 in cerebral cortex and striatum of wild type
Valeska Lizzi Lagranha, Ursula Matte, Talita Giacomet de Carvalho, Bianca Seminotti, Carolina Coffi Pereira, David M Koeller, Michael Woontner, Stephen I Goodman, Diogo Onofre Gomes de Souza, Moacir Wajner   +9 more
doaj   +1 more source

Influence of 100% and 40% oxygen on penumbral blood flow, oxygen level, and T2*-weighted MRI in a rat stroke model [PDF]

, 2011
Accurate imaging of the ischemic penumbra is a prerequisite for acute clinical stroke research. T2* magnetic resonance imaging (MRI) combined with an oxygen challenge (OC) is being developed to detect penumbra based on changes in blood deoxyhemoglobin ...
Baskerville, Tracey, Deuchar, Graeme A., Holmes, William M., Macrae, I. Mhairi, McCabe, Chris, Robertson, Craig A., Santosh, Celestine   +6 more
core   +1 more source

A Systematic Relationship Between Functional Connectivity and Intracortical Myelin in the Human Cerebral Cortex

Cerebral Cortex, 2017
Research in the macaque monkey suggests that cortical areas with similar microstructure are more likely to be connected. Here, we examine this link in the human cerebral cortex using 2 magnetic resonance imaging (MRI) measures: quantitative T1 maps ...
Julia M. Huntenburg, P. Bazin, A. Goulas, Christine L. Tardif, A. Villringer, D. Margulies   +5 more
semanticscholar   +1 more source

Progressive Myoclonus Epilepsy: Distinctive MRI Changes in Cerebellar and Motor Networks

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Progressive myoclonus epilepsy (PME) is a rare generalized epilepsy syndrome with a well‐characterized genetic basis. The brain networks that are affected to give rise to the distinctive symptoms of PME are less well understood. Methods Eleven individuals with PME with a confirmed genetic diagnosis and 22 controls were studied.
Jillian M. Cameron, Remika Mito, Samuel F. Berkovic, Graeme D. Jackson   +3 more
wiley   +1 more source

The expression of aristaless-related homeobox in neural progenitors of gyrencephalic carnivore ferrets

Biochemistry and Biophysics Reports, 2021
Aristaless-related homeobox (ARX) has important functions in the development of various organs including the brain. Mutations of the human ARX gene have been associated with malformations of the cerebral cortex such as microcephaly and lissencephaly ...
Hiroki Maeyama, Yohei Shinmyo, Hiroshi Kawasaki   +2 more
doaj  

Anatomical Parcellation of Cortical Language Sites [PDF]

, 2004
Anatomical labeling of cerebral cortical stimulation (CSM) sites is necessary for intelligent computer querying of a rich and unique experimental database examining neural substrates underlying human language production.
Brinkley, James F, Corina, David P, Hertzenberg, X., Martin, Richard F, Ojemann, George A, Poliakov, Andrew V   +5 more
core   +1 more source

Hyperglycaemia does not increase perfusion deficits after focal cerebral ischaemia in male Wistar rats [PDF]

, 2018
Background: Hyperglycaemia is associated with a worse outcome in acute ischaemic stroke patients; yet the pathophysiological mechanisms of hyperglycaemia-induced damage are poorly understood.
Dewar, Deborah, Holmes, William M., MacDonald, Kathleen, Macrae, I. Mhairi, Muir, Keith W., Thow, Lisa A.   +5 more
core   +1 more source

Early Language Impairment as an Integral Part of the Cognitive Phenotype in Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Huntington's disease (HD) speech/language disorders have typically been attributed to motor and executive impairment due to striatal dysfunction. In‐depth study of linguistic skills and the role of extrastriatal structures in HD is scarce.
Arnau Puig‐Davi, Carla Franch‐Marti, Iñigo Ruiz‐Barrio, Frederic Sampedro, Jesus Perez‐Perez, Jordi A. Matias‐Guiu, Fernando Cuetos, Gonzalo Olmedo‐Saura, Laura Perez‐Carasol, Andrea Horta‐Barba, Ignacio Aracil‐Bolaños, Javier Pagonabarraga, Jaime Kulisevsky, Saul Martinez‐Horta   +13 more
wiley   +1 more source