Results 11 to 20 of about 355,372 (304)

Intravenous tPA therapy does not worsen acute intracerebral hemorrhage in mice [PDF]

open access: yes, 2013
Tissue plasminogen activator (tPA) is the only FDA-approved treatment for reperfusing ischemic strokes. But widespread use of tPA is still limited by fears of inadvertently administering tPA in patients with intracerebral hemorrhage (ICH).
Arai, Ken   +13 more
core   +11 more sources

Function of BID - a molecule of the bcl-2 family - in ischemic cell death in the brain [PDF]

open access: yes, 2002
Mitochondrial mechanisms, particularly the release of cytochrome c, play a role in the death of nerve and glial cells in cerebral ischemia. We have currently investigated whether BID, a proapoptotic molecule of the bcl-2 family and promoter of the ...
Amin-Hanjani, Sepideh   +5 more
core   +1 more source

Wide therapeutic time window for nimesulide neuroprotection in a model of transient focal cerebral ischemia in the rat [PDF]

open access: yes, 2004
Results from several studies indicate that cyclooxygenase-2 (COX-2) is involved ischemic brain injury. The purpose of this study was to evaluate the neuroprotective effects of the selective COX-2 inhibitor nimesulide on cerebral infarction and ...
Candelario-Jalil, Eduardo   +4 more
core   +1 more source

A systematic review of neuroprotective strategies after cardiac arrest: from bench to bedside (Part I - Protection via specific pathways). [PDF]

open access: yes, 2014
Neurocognitive deficits are a major source of morbidity in survivors of cardiac arrest. Treatment options that could be implemented either during cardiopulmonary resuscitation or after return of spontaneous circulation to improve these neurological ...
Applegate, Patricia M   +5 more
core   +2 more sources

Variability of the Heart Rhythm as an Additional Marker for Determining Vegetative Functions in Patients with Chronic Cerebral Ischemia [PDF]

open access: yes, 2018
Aim. Practical cardiology is in constant search for non-invasive vascular risk markers. Heart rhythm reflects the body\u27s response to various stimuli of the external and internal environment. Heart rate variability (HRV) has a prognostic and diagnostic
Inhula, N. (Nataliia)
core   +2 more sources

Delayed treatment with nimesulide reduces measures of oxidative stress following global ischemic brain injury in gerbils [PDF]

open access: yes, 2003
Metabolism of arachidonic acid by cyclooxygenase is one of the primary sources of reactive oxygen species in the ischemic brain. Neuronal overexpression of cyclooxygenase-2 has recently been shown to contribute to neurodegeneration following ischemic ...
Alvarez, Dalia   +3 more
core   +1 more source

Barrier mechanisms in neonatal stroke. [PDF]

open access: yes, 2014
Clinical data continue to reveal that the incidence of perinatal stroke is high, similar to that in the elderly. Perinatal stroke leads to significant morbidity and severe long-term neurological and cognitive deficits, including cerebral palsy ...
Chip, Sophorn   +2 more
core   +2 more sources

Selenium-Binding Protein 1 Indicates Myocardial Stress and Risk for Adverse Outcome in Cardiac Surgery [PDF]

open access: yes, 2019
Selenium-binding protein 1 (SELENBP1) is an intracellular protein that has been detected in the circulation in response to myocardial infarction. Hypoxia and cardiac surgery affect selenoprotein expression and selenium (Se) status.
Kühn, Eike C.   +8 more
core   +1 more source

A depletable pool of adenosine in area CA1 of the rat hippocampus [PDF]

open access: yes, 2001
Adenosine plays a major modulatory and neuroprotective role in the mammalian CNS. During cerebral metabolic stress, such as hypoxia or ischemia, the increase in extracellular adenosine inhibits excitatory synaptic transmission onto vulnerable neurons via
Caldwell, Darren   +4 more
core   +1 more source

The future of ischemic stroke: flow from prehospital neuroprotection to definitive reperfusion. [PDF]

open access: yes, 2014
Recent advances in ischemic stroke enable a seamless transition of the patient flow from the prehospital setting to definitive reperfusion, without the arbitrary separation of therapeutic phases of ischemia based on time alone.
Ip, Hing Lung, Liebeskind, David S
core   +1 more source

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