Results 11 to 20 of about 1,149,621 (388)
npj Parkinson's Disease, 2022 Neuroinflammation, in which activated microglia are involved, appears to contribute to the development of Parkinson’s disease (PD). However, the role of microglial activation and the mechanisms governing this process remain uncertain.
Neus Rabaneda-Lombarte +8 more
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MicroRNAs in Cerebral Ischemia [PDF]
Stroke Research and Treatment, 2013 The risk of ischemic stroke increases substantially with age, making it the third leading cause of death and the leading cause of long-term disability in the world. Numerous studies demonstrated that genes, RNAs, and proteins are involved in the occurrence and development of stroke. Current studies found that microRNAs (miRNAs or miRs) are also closely
Yang Wang, Yongting Wang, Guo-Yuan Yang
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The Alterations in Mitochondrial Dynamics Following Cerebral Ischemia/Reperfusion Injury
Antioxidants, 2021 Cerebral ischemia results in a poor oxygen supply and cerebral infarction. Reperfusion to the ischemic area is the best therapeutic approach. Although reperfusion after ischemia has beneficial effects, it also causes ischemia/reperfusion (I/R) injury ...
Jirapong Vongsfak +5 more
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Effects and Mechanisms of Exosomes from Different Sources in Cerebral Ischemia
Cells, 2022 Cerebral ischemia refers to the symptom of insufficient blood supply to the brain. Cells of many different origins participate in the process of repairing damage after cerebral ischemia occurs, in which exosomes secreted by the cells play important roles.
Ruoxi Xie +4 more
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Establishment and Evaluation of a Monkey Acute Cerebral Ischemia Model [PDF]
Clinics, 2020 OBJECTIVES: Cerebral ischemia seriously threatens human health and is characterized by high rates of incidence, disability and death. Developing an ideal animal model of cerebral ischemia that reflects the human clinical features is critical for ...
Li Yan +11 more
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Journal of Medical Science, 2021 Aim. Measure of the histological changes in neurons in the parietal cortex and hippocampus of rats with partial, subtotal, stepwise subtotal, and total cerebral ischemia. Material and Methods. Studies were performed on 84 rats. Partial cerebral ischemia
Lizaveta I. Bon, Nataliya Y. Maksimovich
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Insights into the neuropathology of cerebral ischemia and its mechanisms
Reviews in the Neurosciences, 2020 Cerebral ischemia is a result of insufficient blood flow to the brain. It leads to limited supply of oxygen and other nutrients to meet metabolic demands. These phenomena lead to brain damage.
M. Ahad +11 more
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The transcriptome of cerebral ischemia [PDF]
Brain Research Bulletin, 2012 The molecular causality and response to stroke is complex. Yet, much of the literature examining the molecular response to stroke has focused on targeted pathways that have been well-characterized. Consequently, our understanding of stroke pathophysiology has made little progress by way of clinical therapeutics since tissue plasminogen activator was ...
Charles L. Rosen +3 more
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AG490 protects cerebral ischemia/reperfusion injury via inhibiting the JAK2/3 signaling pathway
Brain and Behavior, 2021 Background Cerebral ischemia/reperfusion injury is a severe problem in patients with brain ischemia. Brain injury caused by the immune response is important in the pathogenesis of cerebral ischemia/reperfusion injury and immune pathways.
Lichao Fan, Lichun Zhou
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Nrf2 Regulates Oxidative Stress and Its Role in Cerebral Ischemic Stroke
Antioxidants, 2022 Cerebral ischemic stroke is characterized by acute ischemia in a certain part of the brain, which leads to brain cells necrosis, apoptosis, ferroptosis, pyroptosis, etc.
Lei Wang +7 more
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