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Ethical Issues in Cerebral Organoid Research
Cambridge Quarterly of Healthcare Ethics, 2023About ten years ago, reports of lab-grown “mini brains” or “brains in a dish” appeared in the media, falling somewhere between the curious and the alarming. The trigger of these reports was a new method to grow three-dimensional neural tissue from human stem cells that recapitulates, to some degree, the early development of brain tissue.
Gardar Arnason +2 more
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The future of cerebral organoids in drug discovery
Seminars in Cell & Developmental Biology, 2021Until the discovery of human embryonic stem cells and human induced pluripotent stem cells, biotechnology companies were severely limited in the number of human tissues that they could model in large-scale in vitro studies. Until this point, companies have been limited to immortalized cancer lines or a small number of primary cell types that could be ...
Max R, Salick +3 more
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Human Cerebral Organoids Recapitulate Gene Expression Programs of Fetal Neocortex Development
Proceedings of the National Academy of Sciences of the United States of America, 2015 Cerebral organoids—3D cultures of human cerebral tissue derived from pluripotent stem cells—have emerged as models of human cortical development. However, the extent to which in vitro organoid systems recapitulate neural progenitor cell proliferation and
Eric Lewitus +2 more
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Optogenetics in the Era of Cerebral Organoids
Trends in Biotechnology, 2019The human brain has been deemed the most complex organ and has captivated neuroscientists for decades. Most studies of this organ have relied on reductionist model systems. Although all model systems are essentially wrong, cerebral organoids so far represent the closest recapitulation of human brain development and disease both in terms of cell ...
Zahra, Shiri +3 more
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Gene-Edited Fluorescent and Mixed Cerebral Organoids
The CRISPR Journal, 2022Cerebral organoids are a promising model to study human brain function and disease, although the high inter-organoid variability is still challenging. To overcome this limitation, we introduce the method of labeled mixed organoids generated from two different human induced pluripotent stem cell (hiPSC) lines, which enables the identification of cells ...
Lisa, Bachmann +5 more
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Breeding Brains? Patients’ and Laymen’s Perspectives on Cerebral Organoids
Regenerative Medicine, 2020Aim: To explore the perspectives of patients and laymen with regard to the development, use and storage of cerebral organoids, in order to contribute to the ethical debate about this technology. Materials & methods: In depth semi-structured interviews with 28 patients and laymen were conducted.
Haselager, D.R. +5 more
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Cerebral Organoids: A Model of Brain Development
Russian Journal of Developmental Biology, 2020The development of the human brain in normal or pathological conditions is currently infeasible to fully reproduce in animal models, warranting a search for alternative solutions. Significant progress has recently been achieved in the development of methods to culture human cerebral organoids.
K. K. Sukhinich, M. A. Aleksandrova
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