Results 91 to 100 of about 472,990 (216)

Engineering organoids as cerebral disease models

Current Opinion in Biotechnology
Cerebral organoids pioneered in replicating complex brain tissue architectures in vitro, offering a vast potential for human disease modeling. They enable the in vitro study of human physiological and pathophysiological mechanisms of various neurological diseases and disorders.
Alexander Geidies, Marija LJ Medar, Hannes M Beyer   +2 more
openaire   +3 more sources

Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia

Advanced Science, EarlyView.
FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni, Qiancheng Zhang, Youhui Jiang, Huiying Yao, Chuqing Zhou, Xiaoyi Tian, Shiyingnan Gao, Jun Zhao, Xinyi Ren, Naxin Xu, Mengshan Fu, Liansheng Zhao, Xueyu Qi, Xueli Yu, Wanjun Guo, Sangmi Chung, Fan Guo, Tao Li   +17 more
wiley   +1 more source

Cerebral organoids exhibit neural cortices-like tissue mimic to human brain.

, 2023
(A) Representative bright-field (left) and immunofluorescence images (right) of cerebral organoids differentiated from OrgCtrl or OrgALS iPSCs line at 60 DIV. Scale bars = 1 mm.
Paria Alipour (14044499), Makoto Urushitani (108130), Charles-Étienne Castonguay (14573784), Ryosuke Takahashi (108123), Patrick A. Dion (7865801), Joshua A. Sonnen (11916716), Stefano Stifani (183044), Jay P. Ross (7865792), Boting Li (14573787), Daniel Rochefort (7865786), Yoshitaka Tamaki (14573781), Helene Catoire (7865783), Guy A. Rouleau (105556)   +12 more
core   +1 more source

Neuromorphic Devices and Computing for Sensing, Memory, and Control

Advanced Science, EarlyView.
This review introduces neuromorphic devices made from diverse materials. These devices mimic neuronal functions and architectures and, when integrated with artificial or biological computing, can form closed loops with neurons for pressure, optical, acoustic, and biochemical sensing and modulation.
Zhengguang Zhu, Nicholas Schaffer, Xiao Yang   +2 more
wiley   +1 more source

Actividades físico-deportivas y daño cerebral adquirido

, 2021
El presente documento recoge el resumen y las conclusiones de un taller sobre actividades físico-deportivas y daño cerebral adquirido (DCA). También para las personas con DCA, la práctica de actividades deportivas puede constituir un importante factor de
Federación Española de Daño Cerebral
core  

Niche‐Mediated Neural Priming Enables Robust and Scalable Generation of Human Choroid Plexus Organoids

Advanced Science, EarlyView.
Compared to E8, mTeSR1 culture downregulated WNT and TGF‑β signaling, and upregulated neural differentiation pathways, enhancing neural priming. Under skin organoid induction conditions, mTeSR1‑cultured hESCs generated organoids with significantly higher neuroepithelial differentiation.
Zhongliang Chen, Liangxia Jiang, Xianbin Wang, Lili Zhong, Rongcan Luo, Min Su, Liangzhao Chu, Peng Luo   +7 more
wiley   +1 more source

Molecular Glue Degraders Enhance CAPRIN1‐Dependent Lysosomal Degradation of APP and Reduce Amyloid β in Alzheimer's Disease

Advanced Science, EarlyView.
A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung, Xu Wang, Bin Liu, Raktim Roy, Nancy Jaiswal, Ratan K. Rai, Yuichiro Takagi, Cen Gao, Lifan Zeng, Ho‐Yin Lo, Reagan K. Wohlford, Ryan K. Higgins, Bruce T. Lamb, Anantha Shekhar, Anita C. Bellail, Chunhai Hao   +15 more
wiley   +1 more source

Human cerebral organoids: Complex, versatile, and human-relevant models of neural development and brain diseases

Neural Regeneration Research
The brain is the most complex human organ, and commonly used models, such as two-dimensional-cell cultures and animal brains, often lack the sophistication needed to accurately use in research.
Raquel Coronel, Rosa González-Sastre, Patricia Mateos-Martínez, Laura Maeso, Elena Llorente-Beneyto, Sabela Martín-Benito, Viviana S. Costa Gagosian, Leonardo Foti, Ma Carmen González-Caballero, Victoria López-Alonso, Isabel Liste   +10 more
doaj   +1 more source

Expanding Genetic Code to Generate Human Brain Organoids with Both Vasculature and Microglia‐Like Cells

Advanced Science, EarlyView.
Using genetic code expansion, we engineered vascularized human cerebral organoids (vhCOs) with microglia‐like cells and blood‐brain barrier features. vhCOs recapitulate neurovascular interactions, regional identities, and neuronal subtypes resembling the fetal brain.
Haishuang Lin, Yaqing Wang, Hu Du, Yuxin Qin, Haoyu Zhang, Peng Wang, Lin Wei, Jianhua Qin   +7 more
wiley   +1 more source

The Ethical Paradoxes of Human Cerebral Organoids Technology and Their Solutions

Yixue yu zhexue
Human brain organoids are used to study the developmental mechanisms of the human brain, brain diseases, and more. However, the more advanced the human cerebral organoids are, the intenser the ethical debates it provokes are.
Bin HUANG, Xiang HOU
doaj   +1 more source