Results 101 to 110 of about 472,990 (216)

Temporal Trajectories of the Tau Aggregate Interactome Reveal Stage‐Specific Vulnerabilities in Alzheimer's Disease

Advanced Science, EarlyView.
Tau populations with different aggregation states associate with distinct sets of proteins in the Alzheimer's disease brain. Proteomic discovery combined with single‐molecule analysis in neurons reveals dynamic associations involving proteostasis, metabolism and RNA biology.
Dorothea Böken, Paula Beltran Lobo, Yunzhao Wu, Lyla A. Rowe, Emre Fertan, Cara L. Croft, Maria Jimenez‐Sanchez, Dezerae Cox, David Klenerman   +8 more
wiley   +1 more source

Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain [PDF]

, 2020
A population of >6 million people worldwide at high risk of Alzheimer’s disease (AD) are those with Down Syndrome (DS, caused by trisomy 21 (T21)), 70% of whom develop dementia during lifetime, caused by an extra copy of β-amyloid-(Aβ)-precursor-protein ...
Yeap, YJ, Brunmeir, R., Zetterberg, H., Shao, X, Becker, DL, Soininen, H., Francis, PT, Dunn, NR, Rostagno, A., Blennow, K, Strydom, A, Brinkmalm, G., Murray, A, Pervushin, K., Brinkmalm, G, Hamburg, S., Hamburg, S, Rovelet-Lecrux, A, Hardy, J, Kostovi, I, Portelius, E, Goh, P.A., Šimić, G, Startin, C, Hardy, J., Francis, P.T., Pervushin, K, Martin, JE, Portelius, E., Wallon, D., Wallon, D, Groet, J, Murray, A., Ghiso, J., Gough, G., Phillips, M., Turmaine, M., Blennow, K., Krsnik, Ž., Startin, Carla; id_orcid, Koschut, D., Ghiso, J, Koschut, D, O'Brien, NL, Kostović, I, Rovelet-Lecrux, A., Alić, I., Šimić, G., Gough, G, Krsnik, Z, Foo, JN, Kvartsberg, H., Dunn, N.R., Volpi, E., Hithersay, R,, Hithersay, R, Goh, PA, LonDownS Consortium, Nižetić, D, O'Brien, N.L., Brunmeir, R, Nižetić, D., Gkanatsiou, E, Mitrečić, D, Zetterberg, H, Turmaine, M, Startin, C., Becker, D.L., Mitrečić, D., Gkanatsiou, E., Rostagno, A, Mok, KY, Shao, X,, Martin, J.E., Alić, I, Groet, J., Kostović, I., Havlicek, S., Soininen, H, Phillips, M, Mok, K.Y., Foo, J.N., Strydom, A., Volpi, E, Yeap, Y.J., Kvartsberg, H, Havlicek, S, Turmaine, Mark, Blennow, Kaj,, Mitrečić, Dinko, Koschut, David, Goh, P. A., Groet, Jürgen, Rostagno, Agueda, Wallon, David, Shao, X. W., Becker, David L., Kostović, Ivica, Pervushin, Konstantin, Yeap, Yee Jie, Kvartsberg, Hlin, Dunn, N. R., Alić, Ivan, Soininen, Hilkka, Mok, Kin Y., Tybulewicz, Victor, Brunmeir, Reinhard, Karmiloff-Smith, Annette, Foo, J. N., Brinkmalm, Gunnar,, O'Brien, N. L., Brinkmalm, Gunnar, Goh, Pollyanna A., Volpi, Emanuela, Portelius, Erik, O’Brien, Niamh L., Francis, P. T., Hardy, John, Strydom, Andre, Yeap, Y. J., Krsnik, Željka, Gkanatsiou, Eleni,, Gkanatsiou, Eleni, Gough, Gillian, Becker, D. L., Zetterberg, Henrik,, Šimić, Goran, Martin, Joanne E., Fisher, Elizabeth, Mok, K. Y., ?, ?, Foo, Jia Nee, Nižetić, Dean, Murray, Aoife, Ghiso, Jorge, Hithersay, R., Rovelet-Lecrux, Anne, Portelius, Erik,, Havlicek, Steven, Wiseman, Frances, Francis, Paul T., Zetterberg, Henrik, Martin, J. E., Shao, Xiaowei, Hithersay, Rosalyn, Dunn, N. Ray, Blennow, Kaj, Kostovi, I., Startin, Carla, Kvartsberg, Hlin,, Hamburg, Sarah, Phillips, Margaret   +151 more
core   +1 more source

AARS2‐SIRT5‐Driven DLD K445 Lactylation Promotes Cuproptosis Resistance in Glioblastoma Stem Cells

Advanced Science, EarlyView.
Lactylation of DLD at K445 by AARS2 suppresses PDH complex activity and reduces DLAT lipoylation, thereby conferring cuproptosis resistance in glioblastoma stem cells. SIRT5‐mediated delactylation restores PDH function and enhances cuproptosis sensitivity.
Mingtian Ding, Haibiao Xu, Cen Liu, Yangyin Ding, Shuai Wang, Jun Yin, Tao Fu, Xiao Jiang, Yuning Chen, Hui Luo, Rui Li, Zhengxin Chen, Huibo Wang   +12 more
wiley   +1 more source

GNG5 Controls the Number of Apical and Basal Progenitors and Alters Neuronal Migration During Cortical Development

Frontiers in Molecular Biosciences, 2020
Cortical development is a very complex process in which any temporal or spatial alterations can give rise to a wide range of cortical malformations. Among those malformations, periventricular heterotopia (PH) is characterized by clusters of neurons that ...
Ane Cristina Ayo-Martin, Ane Cristina Ayo-Martin, Christina Kyrousi, Rossella Di Giaimo, Rossella Di Giaimo, Silvia Cappello   +5 more
doaj   +1 more source

Apolipoprotein E regulates lipid metabolism and α-synuclein pathology in human iPSC-derived cerebral organoids

, 2021
APOE4 is a strong genetic risk factor for Alzheimer’s disease and Dementia with Lewy bodies; however, how its expression impacts pathogenic pathways in a human-relevant system is not clear.
Fu, Yuan, Dickson, Dennis W., Pan, Meixia, Younkin, Steven G., Lu, Wenyan, Li, Fuyao, Ertekin-Taner, Nilüfer, Shue, Francis, Graff-Radford, Neill R., Davis, Mary D., Wang, Xue, Kanekiyo, Takahisa, Bu, Guojun, Wszolek, Zbigniew K., Zhao, Jing, Chen, Kai, Liu, Chia Chen, Brafman, David A., Martens, Yuka A., Asmann, Yan W., Han, Xianlin, Xu, Ziying, Ren, Yingxue   +22 more
core   +1 more source

Mitochondrial Protection and Neural Repair via ROS‐Responsive Biomimetic Nanoparticles in Intracerebral Hemorrhage

Advanced Science, EarlyView.
A ROS‐responsive biomimetic nanoparticle platform co‐delivers DIDS and Mdivi‐1 to protect mitochondria and promote neural repair after intracerebral hemorrhage. By targeting LPAR1/VDAC1‐related mitochondrial dysfunction, the nanotherapy reduces oxidative injury, neuronal apoptosis, and blood‐brain barrier disruption, improving neurological recovery and
Ling Gao, Li Peng, Xiaobin Zheng, Cong Tan, Chuang Wang, Qijiang Xiong, Weiming Chen, Zhao Yang   +7 more
wiley   +1 more source

PBRM1 Deficiency in Microglia Leads to Excessive Neurogenesis and Autism‐Like Behaviors via the CCL5‐CCR1/5‐β‐catenin Signaling Axis

Advanced Science, EarlyView.
Microglial PBRM1 deficiency drives excessive hippocampal neurogenesis by enhancing CCL5–CCR1/5 signaling, leading to autism‐like behaviors. A pro‐inflammatory IL1α+/TNFα+ microglial subset is identified as a key cellular contributor to this process. PBRM1 represses Ccl5 expression at the transcriptional level.
Yang‐Yang Duan, Lin‐Fei Jiao, Pei‐Pei Liu, Chun‐Hui Duan, Xiao Li, Zi‐Han Zhang, Yue‐Qi Zhang, Xin‐Li Ouyang, Hong‐Zhen Du, Sha Liu, Yi Tang, Zhao‐Qian Teng, Chang‐Mei Liu   +12 more
wiley   +1 more source

Cerebral Organoid Research Ethics and Pinning the Tail on the Donkey

Cambridge Quarterly of Healthcare Ethics, 2023
AbstractThe risk of creating cerebral organoids/assembloids conscious enough to suffer is a recurrent concern in organoid research ethics. On one hand, we should, apparently, avoid discovering how to distinguish between organoids that it would be permissible (non-conscious) and impermissible (conscious) to use in research, since if successful we would ...
openaire   +2 more sources

Precision Nanomedicine for Traumatic Neural Injury: Functional Paradigms and Translational Frameworks

Advanced Science, EarlyView.
This review presents a pathology‐driven framework unifying nanomedicine across TBI, SCI, and PNI. Epidemiological evidence and comparative single‐cell transcriptomic reanalysis define shared pathological modules, injury‐specific effectors, and therapeutic bottlenecks. Six functional paradigms connect nanomaterial structure and biological fate to injury‐
Mouyuan Sun, Shuangyang Li, Zhixu He, Jingyi Xie, Yaxian Luo, Xuankai Fan, Jingyu Zhang, Luying Qin, Lianjie Peng, Tao Qiu, Tian Zhang, Huiming Wang, Mengfei Yu   +12 more
wiley   +1 more source

Arhgef1 Deletion Disrupts Early Cortical Neurogenesis via PAK1 Overactivation and Causes Motor Dysfunction in Adulthood

Advanced Science, EarlyView.
ARHGEF1 plays a pivotal role in both embryonic cortical neurogenesis and adult motor function. During early development, it governs genesis of deep‐layer cortical neurons by negatively regulating RAC1/CDC42‐PAK1‐Cofilin signaling. In adulthood, ARHGEF1 is important for the maintenance of neuronal morphology and activity in the motor cortex, ensuring ...
Liuren Li, Xuanyue Ma, Zhenyu Ding, Bang Sun, Linglin Liu, Hei Matthew Yip, Wei Wang, Tianying Wu, Yuan Guo, Yinghui Peng, Shiqing Zhang, Jacque Pak Kan Ip, Li Zhang, Keshen Li, Lei Shi   +14 more
wiley   +1 more source