Results 101 to 110 of about 68,629 (274)

Current Advances of Treatments, Therapeutic Targets, Biomarkers, Novel Drugs, and Machine Learning for Hypopharyngeal Squamous Cell Carcinoma

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Hypopharyngeal squamous cell carcinoma (HSCC) is an aggressive subtype of head and neck squamous cell carcinoma with insidious onset, early metastasis, and dismal prognosis. Conventional multimodal therapy achieves limited survival benefit, highlighting an urgent need for refined precision strategies.
Ce Li, Rui Guan, Rui‐Jie Jiao, Zhi‐Jie Bi, Yang Fu, Yin Wang, Chen‐Yang Xu, Ye Qian, Ran Wei, Sheng‐Da Cao, Wen‐Ming Li, Dong‐Min Wei, Da‐Peng Lei   +12 more
wiley   +1 more source

The functional roles of competitive endogenous RNA (ceRNA) networks in apoptosis in human cancers: The circRNA/miRNA/mRNA regulatory axis and cell signaling pathways

Heliyon
Circular RNAs are noncoding RNAs with circular conformation mainly due to backsplicing event. CircRNAs can potentially impact cell biological processes by interacting with cell signaling pathways.
Mina Shahpari, Mohamad Hashemi, Tayebeh Younesirad, Aida Hasanzadeh, Mohammad mahdi Mosanne, Mohamadreza Ahmadifard   +5 more
semanticscholar   +1 more source

Estrogen-induced circRNA, circPGR, functions as a ceRNA to promote estrogen receptor-positive breast cancer cell growth by regulating cell cycle-related genes

Theranostics, 2021
Estrogen and estrogen receptor (ER)-regulated gene transcriptional events have been well known to be involved in ER-positive breast carcinogenesis. Meanwhile, circular RNAs (circRNAs) are emerging as a new family of functional non-coding RNAs (ncRNAs ...
Lei Wang, Jia Yi, Ling-Yun Lu, Yue-ying Zhang, Lan Wang, Guo-Sheng Hu, Yi-Chen Liu, Jian-Cheng Ding, Hai-Feng Shen, Fang Zhao, Hai-Hua Huang, Wen Liu   +11 more
semanticscholar   +1 more source

From patient to tumor organoid: Culture protocol choice controls glioblastoma tumor architecture and identity

Brain Pathology, EarlyView.
How glioblastoma organoids are made shapes what they become. Fragment‐based cultures preserve extracellular matrix networks, cellular diversity, and primary tumor identity, whereas dissociation‐based cultures shift toward growth‐adapted states and simplified microenvironments. Abstract Patient‐derived tumor organoids are widely used in cancer research,
Jana Slovackova, Ondrej Bernatik, Katarina Cimborova, Martin Barak, Michal Hendrych, Karolina Kocourkova, Marie Sulcova, Jaroslav Olha, Katerina Amruz Cerna, Zdenek Hodny, Radim Jancalek, Dasa Bohaciakova   +11 more
wiley   +1 more source

Out-of-Equilibrium ceRNA Crosstalk

Amongst non-coding RNAs, microRNAs are pivotal post-transcriptionalregulators of gene expression in higher eukaryotes. Through a titration-based mech-anism of interaction with their target RNAs, microRNAs can mediate a weak butpervasive form of RNA cross-regulation, as different endogenous RNAs can be ef-fectively coupled by competing for microRNA ...
Ferro, Elsi, Szischik, Candela L., Cunial, Marta, Ventura, Alejandra C., De Martino, Andrea, Bosia, Carla   +5 more
openaire   +4 more sources

Aberrant ceRNA activity drives lung cancer [PDF]

Cell Research, 2014
In a recent issue of Nature, Kumar et al. demonstrate that the oncogenic potential of the Hmga2 gene is largely due to the ability of its transcript to operate as a competing endogenous RNA in a protein coding-independent manner. The Hmga2 mRNA decoys the let-7 microRNA family to regulate Tgfbr3 expression and enhance TGF-β signaling, thereby promoting
Yvonne, Tay, Florian A, Karreth, Pier Paolo, Pandolfi   +2 more
openaire   +2 more sources

Development of Ferroptosis-Associated ceRNA Network in Periodontitis

International Dental Journal, 2023
Periodontitis is a chronic inflammatory illness that may lead to tooth loosening and even loss, and its pathogenesis is not fully understood. Ferroptosis is an iron-dependent, regulated cell death. The present study aims to find the key ferroptosis-related genes (FRGs) in periodontitis and develop an mRNA-miRNA-lncRNA network to deeply explore the ...
Churen Zhang, Pengxin Xue, Jianguo Ke, Qiaoling Cai   +3 more
openaire   +3 more sources

LncRNA SNHG16 Facilitates Nasopharyngeal Carcinoma Progression by Acting as ceRNA to Sponge miR-520a-3p and Upregulate MAPK1 Expression

Cancer Management and Research, 2021
Qingwei Wu, Yingying Zhao, Runjie Shi, Tao Wang Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of ChinaCorrespondence ...
Wu Q, Zhao Y, Shi R, Wang T
doaj  

Comprehensive analysis of lncRNA‐associated ceRNA network reveals novel potential prognostic regulatory axes in glioblastoma multiforme

Journal of Cellular and Molecular Medicine
Deciphering the lncRNA‐associated competitive endogenous RNA (ceRNA) network is essential in decoding glioblastoma multiforme (GBM) pathogenesis by regulating miRNA availability and controlling mRNA stability. This study aimed to explore novel biomarkers
Maryam Bazrgar, S. A. Mirmotalebisohi, M. Ahmadi, Parisa Azimi, L. Dargahi, H. Zali, A. Ahmadiani   +6 more
semanticscholar   +1 more source

Integrated analysis of lncRNA-miRNA-mRNA ceRNA network in squamous cell carcinoma of tongue

BMC Cancer, 2019
Numerous studies have highlighted that long non-coding RNAs (lncRNAs) can bind to microRNA (miRNA) sites as competing endogenous RNAs (ceRNAs), thereby affecting and regulating the expression of mRNAs and target genes. These lncRNA-associated ceRNAs have
Rui-Sheng Zhou, En-Xin Zhang, Qin-Feng Sun, Zeng-Jie Ye, Jian-Wei Liu, Dai-Han Zhou, Ying Tang   +6 more
semanticscholar   +1 more source