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Construction of ceRNA Regulatory Network in Human Oocytes

Clinical Laboratory, 2023
Cryogenic freezing, often known as cryopreservation, is a technique for preserving human oocytes.In this study, differentially expressed long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs) were identified using the human frozen oocyte dataset GSE69768 from the Gene Expression Database (GEO). Subsequently, combined with the microRNA atlas database,
MingMing, Liang   +5 more
openaire   +2 more sources

ceRNA networks in gynecological cancers progression and resistance

Journal of Drug Targeting, 2023
Gynecological cancers are the second most common types of cancer in women. Clinical diagnosis of these cancers is often delayed or misdiagnosed due to lack of insight into their tumorigenesis mechanism and specific diagnostic biomarkers. Many studies have demonstrated that competing endogenous RNAs (ceRNAs) modulate the progression and resistance of ...
Shuqin, Wu   +4 more
openaire   +2 more sources

PTEN ceRNA networks in human cancer

Methods, 2015
In multiple human cancer types, a close link exists between the expression levels of Phosphatase and Tensin Homolog deleted on chromosome 10 (PTEN) and its oncosuppressive activities. Therefore, an in depth understanding of the molecular mechanisms by which PTEN expression is modulated is crucial in order to achieve a comprehensive knowledge of its ...
Poliseno L, Pandolfi PP
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Competing Endogenous RNAs (CeRNAs): Novel Network in Neurological Disorders

Current Medicinal Chemistry, 2021
Neurological disorders (NDs) comprise a broad range of diseases affecting both central and peripheral nervous systems. These complex multifactorial diseases have a high rate of mortality all over the world, particularly in aged people. Today, new evidence drove our attention to the notable role of noncoding RNAs (ncRNAs) in the progression of NDs ...
Sadra Samavarchi Tehrani   +7 more
openaire   +2 more sources

Exosome circRNAs and ceRNA network profiles in different ANA sera

Immunologic Research, 2022
Increasing evidences show that circRNAs are associated with some autoimmunity diseases either as a biomarker or therapeutic target. Exosomes containing nucleic acids and proteins are found in sera of series diseases and could serve as either diagnostic or therapeutic target. ANA serves as first common diagnostic test for autoimmunity disease, different
Jinhui Hu   +5 more
openaire   +2 more sources

Identification of module biomarkers from the dysregulated ceRNA–ceRNA interaction network in lung adenocarcinoma

Molecular BioSystems, 2015
The dysregulated ceRNA–ceRNA interaction network in lung adenocarcinoma.
Tingting, Shao   +8 more
openaire   +2 more sources

MicroRNAs and ceRNAs: therapeutic implications of RNA networks

Expert Opinion on Biological Therapy, 2014
A new concept of gene regulation, in which competitive endogenous RNAs (ceRNAs) compete for common microRNAs (miRNAs), suggests that mRNA targets have an active role as key elements in the regulation of miRNA availability within cells. ceRNAs are considered to be natural decoys of miRNA activity and can influence the expression of multiple miRNAs.A new
Dana Elena, Giza   +2 more
openaire   +2 more sources

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