Results 221 to 230 of about 4,440,633 (238)

MicroRNAs and ceRNAs: therapeutic implications of RNA networks

Expert Opinion on Biological Therapy, 2014
A new concept of gene regulation, in which competitive endogenous RNAs (ceRNAs) compete for common microRNAs (miRNAs), suggests that mRNA targets have an active role as key elements in the regulation of miRNA availability within cells. ceRNAs are considered to be natural decoys of miRNA activity and can influence the expression of multiple miRNAs.A new
Dana Elena, Giza, Catalin, Vasilescu, George A, Calin   +2 more
openaire   +2 more sources

Identification of module biomarkers from the dysregulated ceRNA–ceRNA interaction network in lung adenocarcinoma

Molecular BioSystems, 2015
Abstract Competitive endogenous RNA (ceRNA) represents a novel layer of gene regulation that plays important roles in the physiology and development of diseases such as cancer and its dysregulation could contribute to cancer pathogenesis. Here, we have proposed a computational method to systematically identify genome-wide dysregulated
Tingting, Shao, Aiwei, Wu, Juan, Chen, Hong, Chen, Jianping, Lu, Jing, Bai, Yongsheng, Li, Juan, Xu, Xia, Li   +8 more
openaire   +2 more sources

ceRNAs and ceRNA Networks in Normal and Malignant Hematopoiesis and Their Therapeutic Implications

Blood, 2013
Abstract We will discuss exciting new data regarding the role of pseudogenes, long intergenic non-coding RNAs (lincRNAs) and miRNAs in the pathogenesis of leukemia and lymphoma, as also studied in vivo in the mouse, and their therapeutic implications.
openaire   +1 more source

VECTOR: An Integrated Correlation Network Database for the Identification of CeRNA Axes in Uveal Melanoma

Genes, 2021
Davide Barbagallo, Michele Purrello, Marco Ragusa   +2 more
exaly  

Identification of Immune-Related Gene Signature and Prediction of CeRNA Network in Active Ulcerative Colitis

Frontiers in Immunology, 2022
Y Eugene Chin
exaly  

Comprehensive characterization of a drug-resistance-related ceRNA network across 15 anti-cancer drug categories

Molecular Therapy - Nucleic Acids, 2021
Xiuyun Shen, Desi Shang
exaly  

Integrated analysis of a ceRNA network reveals potential prognostic lncRNAs in gastric cancer

Cancer Medicine, 2020
Mingran Qi, Fan Li
exaly  

Identification of Functional lncRNAs Associated With Ovarian Endometriosis Based on a ceRNA Network

Frontiers in Genetics, 2021
Tian Wang
exaly  

ceRNA regulatory network of FIH inhibitor as a radioprotector for gastrointestinal toxicity by activating the HIF-1 pathway

Molecular Therapy - Nucleic Acids, 2021
Ming-Hui Cheng, Zi-Qi Zhang
exaly  

Integrated analysis of circRNA-associated ceRNA network in ischemic stroke

Frontiers in Genetics, 2023
exaly