Results 211 to 218 of about 19,790 (218)
Construction of an lncRNA-mediated ceRNA network to investigate the inflammatory regulatory mechanisms of ischemic stroke. [PDF]
Xu M +7 more
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ceRNA networks in gynecological cancers progression and resistance
Journal of Drug Targeting, 2023Gynecological cancers are the second most common types of cancer in women. Clinical diagnosis of these cancers is often delayed or misdiagnosed due to lack of insight into their tumorigenesis mechanism and specific diagnostic biomarkers. Many studies have demonstrated that competing endogenous RNAs (ceRNAs) modulate the progression and resistance of ...
Shuqin, Wu +4 more
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Construction of ceRNA Regulatory Network in Human Oocytes
Clinical Laboratory, 2023Cryogenic freezing, often known as cryopreservation, is a technique for preserving human oocytes.In this study, differentially expressed long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs) were identified using the human frozen oocyte dataset GSE69768 from the Gene Expression Database (GEO). Subsequently, combined with the microRNA atlas database,
MingMing, Liang +5 more
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PTEN ceRNA networks in human cancer
Methods, 2015In multiple human cancer types, a close link exists between the expression levels of Phosphatase and Tensin Homolog deleted on chromosome 10 (PTEN) and its oncosuppressive activities. Therefore, an in depth understanding of the molecular mechanisms by which PTEN expression is modulated is crucial in order to achieve a comprehensive knowledge of its ...
Poliseno L, Pandolfi PP
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MicroRNAs and ceRNAs: therapeutic implications of RNA networks
Expert Opinion on Biological Therapy, 2014A new concept of gene regulation, in which competitive endogenous RNAs (ceRNAs) compete for common microRNAs (miRNAs), suggests that mRNA targets have an active role as key elements in the regulation of miRNA availability within cells. ceRNAs are considered to be natural decoys of miRNA activity and can influence the expression of multiple miRNAs.A new
Dana Elena, Giza +2 more
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Molecular BioSystems, 2015
Abstract Competitive endogenous RNA (ceRNA) represents a novel layer of gene regulation that plays important roles in the physiology and development of diseases such as cancer and its dysregulation could contribute to cancer pathogenesis. Here, we have proposed a computational method to systematically identify genome-wide dysregulated
Tingting, Shao +8 more
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Abstract Competitive endogenous RNA (ceRNA) represents a novel layer of gene regulation that plays important roles in the physiology and development of diseases such as cancer and its dysregulation could contribute to cancer pathogenesis. Here, we have proposed a computational method to systematically identify genome-wide dysregulated
Tingting, Shao +8 more
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ceRNAs and ceRNA Networks in Normal and Malignant Hematopoiesis and Their Therapeutic Implications
Blood, 2013Abstract We will discuss exciting new data regarding the role of pseudogenes, long intergenic non-coding RNAs (lincRNAs) and miRNAs in the pathogenesis of leukemia and lymphoma, as also studied in vivo in the mouse, and their therapeutic implications.
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Screening of Key Genes in Retinoblastoma and Construction of ceRNA Regulatory Network
2023Jiaxin Guo +6 more
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