Results 211 to 218 of about 19,790 (218)

ceRNA networks in gynecological cancers progression and resistance

Journal of Drug Targeting, 2023
Gynecological cancers are the second most common types of cancer in women. Clinical diagnosis of these cancers is often delayed or misdiagnosed due to lack of insight into their tumorigenesis mechanism and specific diagnostic biomarkers. Many studies have demonstrated that competing endogenous RNAs (ceRNAs) modulate the progression and resistance of ...
Shuqin, Wu   +4 more
openaire   +2 more sources

Construction of ceRNA Regulatory Network in Human Oocytes

Clinical Laboratory, 2023
Cryogenic freezing, often known as cryopreservation, is a technique for preserving human oocytes.In this study, differentially expressed long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs) were identified using the human frozen oocyte dataset GSE69768 from the Gene Expression Database (GEO). Subsequently, combined with the microRNA atlas database,
MingMing, Liang   +5 more
openaire   +2 more sources

PTEN ceRNA networks in human cancer

Methods, 2015
In multiple human cancer types, a close link exists between the expression levels of Phosphatase and Tensin Homolog deleted on chromosome 10 (PTEN) and its oncosuppressive activities. Therefore, an in depth understanding of the molecular mechanisms by which PTEN expression is modulated is crucial in order to achieve a comprehensive knowledge of its ...
Poliseno L, Pandolfi PP
openaire   +3 more sources

MicroRNAs and ceRNAs: therapeutic implications of RNA networks

Expert Opinion on Biological Therapy, 2014
A new concept of gene regulation, in which competitive endogenous RNAs (ceRNAs) compete for common microRNAs (miRNAs), suggests that mRNA targets have an active role as key elements in the regulation of miRNA availability within cells. ceRNAs are considered to be natural decoys of miRNA activity and can influence the expression of multiple miRNAs.A new
Dana Elena, Giza   +2 more
openaire   +2 more sources

Identification of module biomarkers from the dysregulated ceRNA–ceRNA interaction network in lung adenocarcinoma

Molecular BioSystems, 2015
Abstract Competitive endogenous RNA (ceRNA) represents a novel layer of gene regulation that plays important roles in the physiology and development of diseases such as cancer and its dysregulation could contribute to cancer pathogenesis. Here, we have proposed a computational method to systematically identify genome-wide dysregulated
Tingting, Shao   +8 more
openaire   +2 more sources

ceRNAs and ceRNA Networks in Normal and Malignant Hematopoiesis and Their Therapeutic Implications

Blood, 2013
Abstract We will discuss exciting new data regarding the role of pseudogenes, long intergenic non-coding RNAs (lincRNAs) and miRNAs in the pathogenesis of leukemia and lymphoma, as also studied in vivo in the mouse, and their therapeutic implications.
openaire   +1 more source

Screening of Key Genes in Retinoblastoma and Construction of ceRNA Regulatory Network

2023
Jiaxin Guo   +6 more
openaire   +1 more source

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