Results 31 to 40 of about 39,559 (211)

Transforming Brain Health With Neurotechnology Convergence (Part II): Intelligent Neurointervention Systems for Neurological Disorders

Brain Health, EarlyView.
ABSTRACT Neurological disorders represent a critical domain within global health, necessitating advanced interventions to address complex pathologies such as tumors, functional disorders, and cerebrovascular diseases. Despite the proven benefits of early intervention, current treatment paradigms face significant challenges: (1) limited precision in ...
Qing Ye, Fei Peng, Chao Pan, Ping Zhang, Xuewei Xie, Zixiao Li, Yingxin Tang, Danyang Chen, Yuanwei Li, Jiawen Wu, Zao Han, Qing Dai, Quansheng Gu, Jizong Zhao, Zhouping Tang   +14 more
wiley   +1 more source

Effet-dose de l’acide oléique alimentaire. Cet acide est-il conditionnellement essentiel ?

Oléagineux, Corps gras, Lipides, 2000
Dans un travail précédent [1] nous avons montré que, globalement, au terme de la période de gestation-lactation chez des rats de 21 jours, la carence alimentaire en acide oléique entraîne une diminution de la concentration en 18:1(n-9); la synthèse ...
Bourre Jean-Marie, Dumont Odile, Durand Georges   +2 more
doaj   +1 more source

C9ORF72 knockdown triggers FTD-like symptoms and cell pathology in mice

Frontiers in Cellular Neuroscience, 2023
The GGGGCC intronic repeat expansion within C9ORF72 is the most common genetic cause of ALS and FTD. This mutation results in toxic gain of function through accumulation of expanded RNA foci and aggregation of abnormally translated dipeptide repeat ...
Maria-Belen Lopez-Herdoiza, Stephanie Bauché, Baptiste Wilmet, Caroline Le Duigou, Delphine Roussel, Magali Frah, Jonas Béal, Gabin Devely, Susana Boluda, Petra Frick, Delphine Bouteiller, Sébastien Dussaud, Pierre Guillabert, Carine Dalle, Magali Dumont, Agnes Camuzat, Dario Saracino, Mathieu Barbier, Gaelle Bruneteau, Phillippe Ravassard, Manuela Neumann, Manuela Neumann, Sophie Nicole, Isabelle Le Ber, Alexis Brice, Morwena Latouche, Morwena Latouche   +26 more
doaj   +1 more source

Le cerveau social

, 2023
Le cerveau social, IEA de Paris, 13 mars 2023. Conférence de Jean Decety, ancien chercheur-résident de l'IEA de Paris, dans le cadre de la Semaine du cerveau ...
Decety
core   +1 more source

A phase 3, randomized clinical trial of soticlestat as adjunctive therapy for Lennox–Gastaut syndrome

Epilepsia, EarlyView.
Soticlestat as adjunctive therapy for Lennox–Gastaut syndrome. Abstract Objective There remains a need for new treatments for Lennox–Gastaut syndrome (LGS), a developmental and epileptic encephalopathy with a heterogenous patient population that often requires polytherapy. The phase 3, randomized SKYWAY study (NCT04938427) investigated the efficacy and
Renzo Guerrini, Eric D. Marsh, Wei‐Ping Liao, Katsumi Imai, Ruzica Kravljanac, Anna Altmann, Cecil D. Hahn, Stéphane Auvin, Jimmy Schiemann, Yasir Khan, Pranab Mitra, Sarah I. Sheikh, Philipp von Rosenstiel, Mahnaz Asgharnejad, Dennis Dlugos, Venkatesha Murthy   +15 more
wiley   +1 more source

Listening across frequencies: Capturing seizures of all patients to advance antiseizure medication development

Epilepsia, EarlyView.
Abstract Seizure frequency has been the primary endpoint in epilepsy trials, with enrollment usually requiring ≥4 seizures per month. This threshold is more and more misaligned with clinical reality, as the availability of more treatment options has reduced baseline seizure burden, with a risk of excluding a proportion of patients from trials. Although
Stéphane Auvin, Jacqueline French
wiley   +1 more source

Raconte-moi une histoire : La rencontre entre mythologie égyptienne et les neurosciences de l'éducation au service des jeunes placés en institution

Cortica, 2023
L’objectif central de ce travail est d’oser la multidisciplinarité entre sciences sociales et neuroscience afin de mieux cibler l’intervention auprès des jeunes ayant vécus des traumatismes.
Olivier Mottier
doaj   +1 more source

Diagnosis and management guidelines for infantile epileptic spasms syndrome around the world: A scoping review and comparative study of international approaches

Epilepsia, EarlyView.
Abstract Objective Infantile epileptic spasms syndrome (IESS) is an epileptic encephalopathy requiring rapid diagnosis and treatment to optimize neurodevelopmental outcomes. Although multiple national and regional guidelines exist, recommendations vary.
Gozde Erdemir, Chethan K. Rao, Anne Francine Pino, Christina Briscoe, Debopam Samanta, Jo M. Wilmshurst, Sonal Bhatia, Jessica L. Carpenter, Christina Hoei‐Hansen, Puneet Jain, Tommy Stodberg, Robyn Whitney, Ryuki Matsuura, Karina Rosso Astorga, Keryma Acevedo Gallinato, Pratibha Singhi, Aristides Hadijinicolaou, Gia Melikishvili, Patricia Smeyers, Nicola Specchio, Stéphane Auvin, Pediatric Epilepsy Research Consortium Infantile Spasm Work Group and International Committee   +21 more
wiley   +1 more source

Trajectory of irritability in children and youth in Ontario, Canada, throughout the COVID‐19 pandemic

JCPP Advances, EarlyView.
This study explored how irritability in children and youth changed during the COVID‐19 pandemic and its impact on mental health. Results showed a gradual decline in irritability, with factors like age, parental anxiety, and resilience influencing its trajectory.
Theodore C. K. Cheung, Katherine T. Cost, Ronda F. Lo, Evdokia Anagnostou, Catherine S. Birken, Alice Charach, Suneeta Monga, Elizabeth Kelley, Rob Nicolson, Paul D. Arnold, Christie Burton, Daphne J. Korczak, Jennifer Crosbie   +12 more
wiley   +1 more source

Les « plis de la mémoire » chez Descartes et ses contemporains : médecine et métaphysique

Cahiers François Viète
This article discusses the issue of memory traces, and more specifically the notion of « fold of memory » in René Descartes and some of his contemporaries and successors.
Juliette Morice
doaj   +1 more source