Results 121 to 130 of about 70,554 (222)

Sex differences in genomics, immune microenvironment and immunotherapy response in adult grade 4 gliomas

Clinical and Translational Discovery, Volume 6, Issue 2, April 2026.
Overall survival of patients with brain tumors receiving ICIs treatment Abstract Purpose Sex differences in the prevalence of gliomas have been reported; however, whether there are sex differences in the development and immunotherapy of gliomas remains poorly understood.
Feng Tang, Zhen‐Yuan Liu, Xi Chen, Jin‐Zhou Yang, Zhi‐Qiang Li   +4 more
wiley   +1 more source

Long‐term results of palliative placement of very low‐axial force self‐expandable metallic stents for malignant colorectal obstruction

DEN Open, Volume 6, Issue 1, April 2026.
Abstract Objectives Stent placement is a standard option for palliative decompression in patients with malignant colorectal obstruction. Long‐term stent placement is associated with perforation, migration, and stent occlusion. Perforation is associated with life expectancy.
Rika Kyo, Takashi Sasaki, Shuntaro Yoshida, Hiroyuki Isayama, Tomonori Yamada, Toshiyuki Enomoto, Yorinobu Sumida, Toshio Kuwai, Masafumi Tomita, Takeaki Matsuzawa, Rintaro Moroi, Toshiyasu Shiratori, Yoshihisa Saida   +12 more
wiley   +1 more source

Effects of Cetuximab Combined with Celecoxib on Apoptosis and KDR and AQP1 
Expression in Lung Cancer

Chinese Journal of Lung Cancer, 2013
Background and objective Neoadjuvant chemotherapy is a new development in the treatment of lung cancer. In recent years, cetuximab and celecoxib have been commonly used in this procedure.
Honggang XIA, Jianfei YE, Hongyu BAI, Changli WANG   +3 more
doaj   +1 more source

A Genome‐Wide Association Study of Colorectal Cancer Mortality Outcomes Among Individuals of African and Admixture Ancestry

Molecular Carcinogenesis, Volume 65, Issue 4, Page 422-433, April 2026.
ABSTRACT African Americans have the highest colorectal cancer (CRC) mortality rates in the United States. We performed the first genome‐wide association study (GWAS) of overall and CRC‐specific mortality among African Americans with incident CRC to identify genetic contributors to CRC outcomes.
Thomas Lawler, Jirong Long, Rene Welch, Irene Ong, Oluwatoyosi Ogunmuyiwa, Rida A. Khatri, Martha Shrubsole, Shaneda Warren Andersen   +7 more
wiley   +1 more source

Multiomics Research Strategies in Cancer: A Growing and Innovative Field

MedComm, Volume 7, Issue 4, April 2026.
This review highlights multiomics strategies in cancer research, focusing on integration methods from genomics to microbiomics. Using colorectal cancer as a key example, it discusses biomarker discovery, data integration via deep learning, and the roles of single‐cell and spatial omics.
Zhenhua Du, Xiaomei Liu, Zhi Lv, Bengang Wang, Yu Xia, Wala Abduljabbar Mohammed Al‐Duais, Lirong Yan, Fuqiang Zhang, Yanke Li   +8 more
wiley   +1 more source

Extracellular and Membrane Protein: Structure, Biological Functions, Diseases, and an Emerging Modality for Drug Discovery

MedComm, Volume 7, Issue 4, April 2026.
Targeted protein degradation represents a paradigm shift from traditional protein inhibition to complete protein elimination. This is achieved through three main strategies for degrading extracellular and membrane proteins: recruitment of cell‐surface LTRs, engagement of intracellular proteins, and receptor‐independent mechanisms.
Mengqing Zhao, Wenhao Yin, Jianjian Han, Huimin Wang, Zheng Liu, Lilong Liu, Wuxiang Mao   +6 more
wiley   +1 more source

A protocol for pre-treatment testing for antibodies to galactose-alpha-1,3-galactose to mitigate the risk of cetuximab hypersensitivity reactions – a retrospective cohort review

Cancer Treatment and Research Communications
Purpose: Cetuximab improves survival in KRAS wildtype metastatic colorectal cancer. However, high rates of hypersensitivity reactions (HSRs) limit its use, with HSR rates up to 10–20 %.
Nicholas Della Marta, Alexander Yuile, Claire Mok, Joe Wei, Meredith Oatley, Tracey Skinner, Samuel Miller, Amanda L. Hudson, Sheryl van Nunen, Stephen J. Clarke, Connie I. Diakos, Madhawa De Silva, David L. Chan, Gavin M. Marx, Nick Pavlakis   +14 more
doaj   +1 more source

Basophil Activation Test for the In Vitro Diagnosis of Tocilizumab Hypersensitivity

Clinical &Experimental Allergy, EarlyView.
Ana Koren, Luka Dejanović, Peter Korošec, Peter Kopač   +3 more
wiley   +1 more source

Determining the Survival Impact and Cost‐Effectiveness of Multi‐Gene Panel Sequencing in Metastatic Colorectal Cancer With Super Learning Approaches

Health Services Research, Volume 61, Issue 2, April 2026.
ABSTRACTObjectiveTo determine the effectiveness and cost‐effectiveness of multi‐gene panel sequencing compared to single‐gene KRAS testing for metastatic colorectal cancer (mCRC).Study Setting and DesignBritish Columbia, Canada (BC) is a provincial single‐payer public healthcare system, and it was the first province to publicly reimburse multi‐gene ...
Emanuel Krebs, Deirdre Weymann, Howard J. Lim, Stephen Yip, Dean A. Regier   +4 more
wiley   +1 more source

Clinical Applications of Phosphoproteomics: Illuminating Cancer Signaling and Enabling Rational Therapeutic Strategies

Cancer Science, Volume 117, Issue 4, Page 885-895, April 2026.
Mass spectrometry‐based phosphoproteomics for mechanistic dissection of cancer signaling pathways and uncovering therapeutic vulnerabilities. ABSTRACT Protein phosphorylation is a central post‐translational modification regulating cellular signaling, frequently dysregulated in cancer.
Hirokazu Shoji, Narikazu Boku, Jun Adachi   +2 more
wiley   +1 more source