Results 131 to 140 of about 50,237 (216)

Squamoid Eccrine Ductal Carcinoma: Case Series of a Rare, Potentially Aggressive Skin Cancer Associated With Immunosuppression

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Squamoid Eccrine Ductal Carcinoma (SEDC) is a rare cutaneous adenexal carcinoma first described in 1997. It has distinct biphasic features on histology which commonly result in misdiagnosis as Bowen disease or cutaneous squamous cell carcinomas (cSCC) if diagnostic skin biopsies are too superficial. This may lead to a delay in diagnosis. It is
Xiang Li Tan, Pooja Patel, Jeva Cernova, Sarah Hogan, Jason Thomson, Efthymios Hadjimichael, Sharanpal Jeetle, Dorota Markiewicz, Michael Sheaff, Nilukshi Wijesuriya, Mark Hawthorne, Graeme Moir, Matthew Stodell, Kapil Bhargava, Suchitra Chinthapalli, Catherine A. Harwood   +15 more
wiley   +1 more source

Cetuximab inhibits tumor angiogenesis in vitro.

, 2015
To collect conditional medium, CAL 27 cells were treated with or without the indicated cetuximab for 12 h, then cultured in fresh serum-deprived medium without cetuximab for another 24 h.
Zhi-Li Zhao (502908), Yi-Fang Zhao (112182), Bing Liu (70818), Wei-Ming Wang (502909), Wen-Feng Zhang (502911), Guang-Tao Yu (696671), Lu Zhang (50563), Ashok B. Kulkarni (467110), Zhi-Jun Sun (467107), Si-Rui Ma (502907)   +9 more
core   +1 more source

Rap2B-mediated reprogramming of the PI3K/AKT signaling axis drives resistance to cetuximab-targeted therapy in colorectal carcinoma

Biological Procedures Online
Background Targeted therapy resistance represents a significant clinical challenge in cancer treatment. Rap2B, a member of the Ras superfamily of small GTPases, is frequently overexpressed in various cancers and has been implicated in promoting tumor ...
Shanshan Zhang, Ying Wei, Tingting Liu, Chenhao Sun, Xiuzhen Ge, Yang Ni, Xiaonan Tang, Mridul Roy, Tingmin Chang, Xiaohong Kang   +9 more
doaj   +1 more source

Mechanisms underlying resistance to cetuximab in the HNSCC cell line: role of AKT inhibition in bypassing this resistance.

, 2011
peer reviewedEGFR is frequently overexpressed in head and neck squamous cell cancer (HNSCC). Cetuximab is a monoclonal antibody designed to interact with EGFR, block its activation, reduce the downstream signaling pathways and induce EGFR internalization.
Rebucci, Magali, Lansiaux, Amelie, Lartigau, Eric, Rezvoy, Nicolas, Vautravers-Dewas, Claire, Guerin, Eric, Wattez, Nicole, Peixoto, Paul, Peyrat, Jean*-Philippe, Dewitte, Amelie, De Nuncques, Marie*-Adeline, Buisine, Marie*-Pierre   +11 more
core   +1 more source

Analysis of Histopathologic Parameters and Patterns of Invasion in Oral Squamous Cell Carcinoma and Their Correlation With Patient Survival

Oral Diseases, EarlyView.
ABSTRACT Introduction Oral squamous cell carcinoma is the most prevalent malignant neoplasm in the head and neck region, and its prognosis is influenced by various histopathological and clinical factors. pTNM tumor staging and invasion patterns are fundamental for predicting therapeutic response and patient survival.
Ana Mirian da Silva Cavalcante, Janderson Fernando da Silva, Tayane Oliveira Gonçalves, Fabrício Bitu Sousa, Erick Ibraim Carlos da Costa, Ana Paula Negreiros Nunes Alves, Jennifer Viana Barbosa, Dayrine Silveira de Paula, Paulo Goberlânio de Barros Silva, Thinali Sousa Dantas   +9 more
wiley   +1 more source

miR-196b strictly regulates and reliably predicts the response to cetuximab in colorectal cancer

Cellular & Molecular Biology Letters
Background Cetuximab resistance severely restricts its effectiveness in the treatment of patients with metastatic colorectal cancer (CRC). Previous studies have predominantly focused on the genetic level, with scant attention to the nongenetic aspects ...
Shiyun Chen, Zhaoli Tan, Yanli Lin, Fang Pang, Xiaojie Wu, Xiang Li, Yumeng Cui, Weiling Man, Ying Li, Yanghua Li, Lu Han, Miaomiao Gou, Zhikuan Wang, Guanghai Dai, Youliang Wang   +14 more
doaj   +1 more source

Inhibition of P‐glycoprotein using photoimmunotherapy in peritoneal metastasis mouse model

Photochemistry and Photobiology, EarlyView.
Photoimmunotherapy (PIT) using photoimmunoconjugates (PICs) can inhibit the function of the ATP‐binding cassette (ABC) transporter P‐glycoprotein (P‐gp) in a mouse model of peritoneal carcinomatosis. Sterile‐filtered PIC was administered in vivo via intraperitoneal (IP) injection 20 days after IP tumor cell implantation of P‐gp‐overexpressing NCI/ADR ...
Kaitlyn A. Moore, Brian Schnoor, Kathryn L. McNaughton, Idrisa Rahman, Benjamin D. Powers, Dana M. Roque, Huang‐Chiao Huang   +6 more
wiley   +1 more source

Alpha‐gal sensitization and the transfusion medicine diagnostic gap: A single‐center study with multi‐institutional TriNetX validation

Transfusion, EarlyView.
Abstract Background Transfusion‐related‐alpha‐gal syndrome (TRAGS) is an emerging transfusion complication in which alpha‐gal (α‐Gal)‐sensitized recipients may experience allergic reactions to B antigen‐containing plasma‐rich blood products. Group O recipients appear to be at greatest risk; group A recipients may also be at risk, whereas group B/AB ...
Homayemem K. Weli, Caitlin Raymond, Sameer Mathur, Chidi Akpamgbo, Caleb Scott, Jill Palmer, Chinelo P. Onyenekwu   +6 more
wiley   +1 more source

Comparative Phenotypic and Molecular Characterisation of Feline Oral Squamous Cell Carcinoma Cell Lines Reveals Marked Biological Heterogeneity

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Feline oral squamous cell carcinoma (FOSCC) is the most common oral malignancy, characterised by aggressive local invasion, frequent bone involvement, and poor prognosis. The limited availability of well‐characterised in vitro models has hindered the understanding of tumour heterogeneity and invasive behaviour.
Qaisar Tanveer, Lisa Y. Pang, Colin Farquharson, Gurå Therese Bergkvist   +3 more
wiley   +1 more source

Impact of RAS/RAF Mutations on Metastatic Treatment Response Following Total Neoadjuvant Therapy in Patients With Stage IV Rectal Cancer

Asia-Pacific Journal of Clinical Oncology, Volume 22, Issue 6, Page 817-829, December 2026.
There is limited understanding of the impact of underlying RAS/RAF mutational status on total neoadjuvant therapy metastatic tumor response rates in curative Stage IV rectal cancer patients. Complete metastatic tumor response to TNT was demonstrated in half as many mRAS as wtRAS patients and disease progression was higher in patients harboring RAS ...
Tracy R. Fitzsimmons, Z. Bunjo, E. L. Neo, A. Badiei, M. Penniment, S. Selva‐Nayagam, A. Ruszkiewicz, J. Wong, T. Sammour   +8 more
wiley   +1 more source