Results 141 to 150 of about 50,237 (216)

DPYD and UGT1A1 Genotype‐Based Dosing for Fluoropyrimidines and Irinotecan Chemotherapy: Variant‐Specific Impact on Treatment Intensity and Toxicity

International Journal of Cancer, Volume 159, Issue 10, Page 2512-2524, 15 November 2026.
Pre‐treatment DPYD and UGT1A1 genotyping is increasingly used to prevent fluoropyrimidine‐ and irinotecan‐related toxicity, but variant‐specific real‐world effects remain unclear. In an unselected cohort of cancer patients with actionable genotypes, genotype‐driven dosing improved safety while preserving treatment exposure in high‐risk DPYD c.1905+1G>A
Martina Gambron, Elena Peruzzi, Samantha Perfler, Marcella Montico, Riccardo Cecchin, Elena De Mattia, Michele Spina, Camilla Lisanti, Serena Corsetti, Luisa Foltran, Fabio Puglisi, Rossana Roncato, Erika Cecchin   +12 more
wiley   +1 more source

Profiling EGFR, c‐MET, and B7H3 co‐expression to guide next‐generation dual‐drug conjugate strategies in colorectal cancer

The Journal of Pathology: Clinical Research, Volume 12, Issue 6, November 2026.
Abstract Epidermal growth factor receptor (EGFR), cellular mesenchymal‐epithelial transition factor (c‐MET), and B7 homolog 3 (B7H3) are important targets for antibody‐based drug development in colorectal cancer (CRC). To overcome the limitations of single‐target antibody therapies – such as limited efficacy, widespread resistance, narrow patient ...
Yanan Yang, Huiyu Li, Shiwei Xiao, Mengxia Jiao, De Wu, Chunxia Ao, Yanggeling Zhang, Siyuan Yan, Shaomei Sun, Chen Yang, Renhong Tang, Xiyuan Wang, Junqiu Yue   +12 more
wiley   +1 more source

Monitoring pharmacodynamic and molecular drug targets in liquid biopsy: Exploratory study in liver cancer with modelling of EGFR Receptor engagement

British Journal of Clinical Pharmacology, Volume 92, Issue 11, Page 3902-3913, November 2026.
Abstract Aim Liquid biopsy is minimally invasive (compared with tissue biopsy) and has previously been used to generate systems data regarding drug elimination via hepatic enzymes and transporters. This study extends quantitative assessment of systems parameters in liquid biopsy to pharmacodynamic (PD) and disease markers relevant to cancer development
Zubida M. Al‐Majdoub, Armin Sepp, Amin Rostami‐Hodjegan, Brahim Achour   +3 more
wiley   +1 more source

Scrotal squamous cell carcinoma: Two HPV‐negative cases with probable UV‐ induced pathogenesis

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Daniel Craus, Ulrike Wieland, Steffi Silling, Julia Hyun, Milan Vidakovic, Frank Oellig, Alexander Kreuter, Valentina Laura Müller   +7 more
wiley   +1 more source

Treatment‐Related Adverse Events and Health‐Related Quality of Life Associated With Immune Checkpoint Inhibitor Treatment for Mucosal Head and Neck Squamous Cell Carcinoma: A Scoping Review

Head &Neck, Volume 48, Issue 11, Page 3152-3172, November 2026.
ABSTRACT Background Supportive care needs of patients receiving immune checkpoint inhibitors (ICIs) for head and neck squamous cell carcinoma (HNSCC) are ill‐defined. Hence, known treatment‐related adverse events (TRAEs) and health‐related quality of life (HRQoL) associated with ICI treatment for HNSCC were examined to inform future supportive care ...
N. D. O'Donnell, E. C. Ward, L. R. Wishart, R. Perera, C. Barrett, K. A. Edmiston, E. Mitchell, A. Pigott, R. Pitt, K. Russell, B. A. Chan, R. Ladwa   +11 more
wiley   +1 more source

Response to a combination therapy of cemiplimab and cetuximab in cutaneous squamous cell carcinoma – a case report

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Katja Schabet, Louisa Schielein, Alexander Enk, Jessica C. Hassel   +3 more
wiley   +1 more source

Robotic‐Assisted Extended Sistrunk Approach (RESA) for Salvage Surgery After Head and Neck Irradiation

Head &Neck, Volume 48, Issue 11, Page 3180-3192, November 2026.
ABSTRACT Background The robotic‐assisted extended “Sistrunk” approach (RESA) is a minimally invasive technique providing access to hypopharyngeal and laryngeal structures via a submental incision and vallecular pharyngotomy, bypassing the base of tongue.
Bartosz Wojtera, Avinash Beharry, Karma Lambercy, Pascaline Dübi, Jelena Todic, Christian Simon   +5 more
wiley   +1 more source

Window-of-Opportunity Study Utilizing Preoperative Cetuximab in Patients with Head and Neck Cancer. [PDF]

Cancer Res Commun
Bruce JY, Glazer TA, Berube LL, Longhurst CA, Yu M, Hu R, Wieland AM, Harari PM, Hartig GK, Iida M, Mehta RK, Lawrence TS, Nyati MK, Poellmann MJ, Bu J, Nickel KP, Hong S, Wheeler DL, Kimple RJ.   +18 more
europepmc   +1 more source

Bioorthogonal Chemistry in Neurobiology: From Imaging to Proteomics

ChemBioChem, Volume 27, Issue 20, 28 October 2026.
This review highlights emerging strategies for labeling neuronal proteins, enabling visualization and quantitative analysis of their expression, localization, and dynamics. By combining genetic code expansion (GCE), metabolic labeling, and click chemistry‐based labeling, these approaches provide powerful routes to study proteins in specific cells and ...
Neil Taylor, João de Sousa‐Lourenço, Ivana Nikić‐Spiegel   +2 more
wiley   +1 more source

Tumor‐Regional Immune Microenvironment: A Critical Factor in the Design of Radiotherapy–Immunotherapy Combination Trials

International Journal of Cancer, Volume 159, Issue 8, Page 1857-1872, 15 October 2026.
ABSTRACT Clinical trials combining radiotherapy (RT) with immune checkpoint blockade (ICB) have shown improved outcomes in only a fraction of patients, and optimal strategies for integrating these modalities remain under intense investigation. With a few exceptions, phase III combination trials have yielded disappointing results.
Xuanwei Zhang, Hui Wang, Weiyan Tang, Kai Kang, Kateryna Onyshchenko, Taotao Huang, Dan Liu, Jianxin Xue, You Lu, Gabriele Niedermann, Ren Luo   +10 more
wiley   +1 more source