Results 121 to 130 of about 50,237 (216)

Unseiin, a Kampo medicine, Reduces the Severity and Manifestations of Skin Toxicities Induced by Cetuximab: A Case Report [PDF]

Cetuximab is an effective drug used to treat patients with recurrent or metastatic head and neck squamous cell carcinoma. Skin toxicities such as paronychia and skin exsiccation are common adverse events caused by cetuximab.
藤原, 和典, 福原, 隆宏, フクハラ, タカヒロ, フジワラ, カズノリ, 小山, 哲史, コヤマ, サトシ, Morisaki, Tsuyoshi, 100002206, Koyama, Satoshi, 3674, 80403418, 40197273, 16997, 90403419, 100001318, 16996, 4942, 16995, Donishi, Ryohei, Fujiwara, Kazunori, Fukuhara, Takahiro, Takeuchi, Hiromi, タケウチ, ヒロミ, 竹内, 裕美, 100000179, 369, Taira, Kenkichiro, 405, 100000417   +28 more
core   +1 more source

Erosive pustular dermatosis of the scalp following cetuximab

, 2014
Cetuximab is a monoclonal antibody that directly inhibits the epidermal growth factor receptor and thus inhibits cell proliferation, angiogenesis and potential metastases whilst promoting apoptosis.
Gajra, J., Gorddard, N., Rubel, D., Bissex, C., Peters, P.   +4 more
core  

Comparison of panitumumab and cetuximab binding.

, 2016
(A) Surface plasmon resonance of EGFR binding to panitumumab and cetuximab. Increasing concentrations of EGFR construct (1.23, 3.7, 11.1, 33.3 and 100 nM) were injected over immobilized antibody.
E. Allen Sickmier (1533271), Robert J. M. Kurzeja (1854391), Evelyn Yang (2033641), Andrew S. Tasker (1463668), Mukta Vazir (3133308), Klaus Michelsen (1261590)   +5 more
core   +1 more source

Targeted Photo‐Induced Elimination of Tumor‐Associated Macrophages Suppresses Cancer Progression in a Murine Model

Cancer Science, EarlyView.
This study demonstrates the selective depletion of tumor‐associated macrophages (TAMs) by targeting CSF1R through near‐infrared photoimmunotherapy (NIR‐PIT). Using a combination of anti‐CSF1R Fab‐IR700 conjugates and localized light irradiation, we achieved tumor suppression and durable antitumor immunity without systemic toxicity.
Kohei Nakajima, Tomomi Uchiyama, Kazuki Funayama, Yuto Goto, Akari Mukaimine, Naoya Ieda, Mikako Ogawa   +6 more
wiley   +1 more source

Cetuximab-Induced MET Activation Acts as a Novel Resistance Mechanism in Colon Cancer Cells

, 2014
Aberrant MET expression and hepatocyte growth factor (HGF) signaling are implicated in promoting resistance to targeted agents; however, the induced MET activation by epidermal growth factor receptor (EGFR) inhibitors mediating resistance to targeted ...
Na Song, Ling Xu, Jing Liu, Xiujuan Qu, Jingdong Zhang, Yunpeng Liu, Shizhou Liu   +6 more
core   +1 more source

Daraxonrasib and Beyond: Pan‐RAS Inhibition, Resistance, and Next‐Generation Strategies

Cancer Science, EarlyView.
ABSTRACT RAS proteins have long been considered difficult therapeutic targets, but allele‐selective inhibitors established the clinical tractability of mutant RAS. Daraxonrasib (RMC‐6236), an oral pan‐RAS inhibitor, has now extended this concept by targeting multiple mutant and wild‐type RAS proteins.
Ryo Honda
wiley   +1 more source

Targeting CD137 enhances the efficacy of cetuximab.

, 2014
International audienceTreatment with cetuximab, an EGFR-targeting IgG1 mAb, results in beneficial, yet limited, clinical improvement for patients with head and neck (HN) cancer as well as colorectal cancer (CRC) patients with WT KRAS tumors.
Ostashko, Anton, Kohrt, Holbrook E, Richards, Lori, Chen, Lieping, Troutner, Emily, Waller, Erin, Cariad Chester, Ronald Levy, Peder Lund, John Sunwoo, Lori Richards, Lieping Chen, Kipp Weiskopf, Wen-Kai Weng, Aurelien Marabelle, Marabelle, Aurelien, Antonia Mueller, Roch Houot, Sunwoo, John, Idit Sagiv-Barfi, Czerwinski, Debra, A. Dimitrios Colevas, Weiskopf, Kipp, Colevas, a Dimitrios, Houot, Roch, Yang-Xin Fu, Matthew J. Goldstein, Anton Ostashko, Chester, Cariad, Hebb, Jonathan, Goldstein, Matthew J, Sagiv-Barfi, Idit, Ruth Lira, Fu, Yang-Xin, Jonathan Hebb, Lira, Ruth, Erin Waller, Mueller, Antonia, Rajapaska, Amanda, Weng, Wen-Kai, Levy, Ronald, Emily Troutner, Debra Czerwinski, Lund, Peder, Amanda Rajapaska, Holbrook E. Kohrt   +45 more
core   +1 more source

Adding Intratumoral Antibody‐Photoabsorber Conjugate Improves Efficacy of Near‐Infrared Photoimmunotherapy (NIR‐PIT)

Cancer Science, EarlyView.
Intravenous (IV) or intratumoral (IT) cetuximab distribution in A431 tumor (essence of Figure 2). ABSTRACT Near‐infrared photoimmunotherapy (NIR‐PIT) is a new type of cancer treatment that specifically kills target cells while sparing normal tissue. This treatment induces cancer cell death by activating a photoreactive dye with near‐infrared light in ...
Miyu Kano, Aki Furusawa, Seiichiro Takao, Makoto Kano, Motofumi Suzuki, Hiroshi Yamamoto, Shuhei Okuyama, Ko Kitamura, Peter L. Choyke, Hisataka Kobayashi   +9 more
wiley   +1 more source

Evaluation of the modulating effect of epidermal growth factor receptor inhibitor cetuximab in carbon-tetrachloride induce hepatic fibrosis in rats

Biochemistry and Biophysics Reports
Liver fibrosis, developed in almost all chronic liver injuries. Epidermal growth factor receptors (EGFR) have been thought to contribute to cirrhosis and liver fibrosis.
Mirza Alimullah, Asif Ul Haque Shuvo, Ishrat Jahan, Iffat Nowshin Ismail, S.M. Mufidul Islam, Mahnaj Sultana, Mahmudur Rahman Saad, Sabbir Raihan, Ferdous Khan, Md. Ashraful Alam, Nusrat Subhan   +10 more
doaj   +1 more source

Allergenicity of α‐Gal‐Containing Products

Allergy, EarlyView.
Frederik Bloch Mangaard, Esben Eller, Per Stahl Skov, Charlotte G. Mørtz, Carsten Bindslev‐Jensen   +4 more
wiley   +1 more source