Results 241 to 250 of about 24,434 (294)

TFEB Orchestrates Stress Recovery and Paves the Way for Senescence Induction in Human Dermal Fibroblasts

Aging Cell, EarlyView.
TFEB dynamics during oxidative stress‐induced premature senescence. The tBHP treatment undermines GSH‐dependent antioxidant mechanisms, leading to increased ROS production and lysosomal damage. In the stress phase, we observed the concomitant inhibition of Akt along with activation of AMPK, together leading to mTOR inhibition and subsequent ...
Lena Guerrero‐Navarro, Pablo Monfort‐Lanzas, Vinzenz Krichbaumer, Mariana E. G. De Araújo, Jlenia Monfregola, Lukas A. Huber, Andrea Ballabio, Pidder Jansen‐Dürr, Maria Cavinato   +8 more
wiley   +1 more source

The STING Signaling: A Novel Target for Central Nervous System Diseases. [PDF]

Cell Mol Neurobiol
Song M, Ren J, Zhu Z, Yi Z, Wang C, Liang L, Tian J, Mao G, Mao G, Chen M.   +9 more
europepmc   +1 more source

hTERT Increases TRF2 to Induce Telomere Compaction and Extend Cell Replicative Lifespan

Aging Cell, EarlyView.
In contrast to the dogma that a subset of short telomeres initiates senescence, hTERT variants unable to maintain telomere length block senescence by stabilizing TRF2 via inhibiting upstream E3 ubiquitin ligases. This noncanonical hTERT function also compacts telomeres and blocks senescence‐associated DNA damage signaling. Cancer cells expressing hTERT
Nancy Adam, Yang Yang, Mahbod Djamshidi, Sara Seifan, Nicholas S. Y. Ting, Joel Glover, Nicolas Touret, Paul M. K. Gordon, K. V. Vineetha Warriyar, Hokan Krowicki, Christine Kim Garcia, Sharon A. Savage, Aaron A. Goodarzi, Duncan M. Baird, Tara L. Beattie, Karl Riabowol   +15 more
wiley   +1 more source

Chromosomal instability shapes the tumor microenvironment of esophageal adenocarcinoma via a cGAS–chemokine–myeloid axis

Beernaert B, Jady-Clark RL, Shah P, Ramon-Gil E, Lawson NM, Brodtman ZD, Tagore S, Stihler F, Carter AS, Clarke S, Liu T, Zhu W, Erdal E, Easton A, Campo L, Browne M, Ash S, Waddell N, Crosby T, Lord SR, Mann DA, Melero I, de Andrea CE, Tijhuis AE, Foijer F, Hammond EM, Akdemir KC, Leslie J, Izar B, Parkes EE.   +29 more
europepmc   +1 more source

Chronic Cellular NAD Depletion Activates a Viral Infection‐Like Interferon Response Through Mitochondrial DNA Leakage

Aging Cell, EarlyView.
Chronic NAD depletion in fibroblasts lowers NAD levels, increases mitochondrial mass, and triggers an interferon‐dependent inflammatory response via mtDNA leakage through VDAC1, activating the cGAS‐STING pathway. This links NAD deficiency to metabolic and inflammatory processes, with implications for diseases associated with NAD decline.
Claudia C. S. Chini, Laura Colman, Eduardo Palmieri, Jessica L. Strange, Sonu Kashyap, Bing Han, Andres Benitez‐Rosendo, Gina L. Ciccio Lopez, Sara Peixoto Rabelo, Shreyartha Mukherjee, Gustavo H. de Souza, John Varga, Ralph G. Meyer, Mirella L. Meyer‐Ficca, Eduardo N. Chini   +14 more
wiley   +1 more source

Effect and mechanism of the miR-1284/EIF4A1 axis on the cGAS-STING pathway under radiotherapy. [PDF]

Transl Cancer Res
Cao W, Su K, Lu C, Li J, Gui X.
europepmc   +1 more source

Primary cilia prevent activation of the cGAS-STING pathway during mouse decidualization. [PDF]

Commun Biol
Li B, He YY, Yao WX, Jin DD, Luo HN, Li MY, Wu Y, Yang ZM.   +7 more
europepmc   +1 more source

Current and future trends in the consumption, sale and purchasing of alcohol‐free and low‐alcohol products in Great Britain, 2014 to 2023

Addiction, EarlyView.
Abstract Background and Aims The UK Government has committed to reducing alcohol consumption by 2025 through increasing the availability of alcohol‐free and low‐alcohol (no/lo) drinks. This study estimated current and future trends in key indicators of the availability, sale, purchasing and consumption of no/lo products in Great Britain.
Luke B. Wilson, Abigail K. Stevely, Inge Kersbergen, Ellen McGrane, Esther C. Moore, Rob E. Pryce, Jamie Brown, John Holmes   +7 more
wiley   +1 more source

Mitochondrial DNA signals driving immune responses: Why, How, Where? [PDF]

Cell Commun Signal
Giordano L, Ware SA, Lagranha CJ, Kaufman BA.   +3 more
europepmc   +1 more source