Results 251 to 260 of about 42,468 (308)

Tianhuang formula attenuates cardiomyocyte pyroptosis in myocardial infarction by suppressing oxidative stress and the cGAS-STING-NLRP3 axis. [PDF]

Front Immunol
Yan M, Chen Y, Cai G, Zhang X, Li K, Luo D, Wang L, Rong X, Guo J.   +8 more
europepmc   +1 more source

Clinical gait analysis use in management of children with cerebral palsy: Qualitative study

Developmental Medicine &Child Neurology, EarlyView.
Barriers and facilitators related to the use of clinical gait analysis (CGA), as identified by healthcare professionals working with children with cerebral palsy and by caregivers. The colored triangles represent the different barriers reported at various stages along the CGA care pathway.
Marie Lévesque‐Jalbert, Katia Turcot, Marie Rousseau‐Demers, Yosra Cherni, Philippe C. Dixon, Laurent Ballaz, Louis‐Nicolas Veilleux, Maxime T. Robert   +7 more
wiley   +1 more source

SIRT4 regulates antiviral and autoimmune responses by promoting cGAS-mediated signaling pathways. [PDF]

EMBO Rep
Yang B, Zhang Y, Wang S, Wu Y, Diao Z, Zhang Q, Lu C, Shen M, Zhang X, Ma S, Yang C, Pei J, Xing H, Liang Y, Wang J.   +14 more
europepmc   +1 more source

STING-associated vasculopathy develops independently of IRF3 in mice [PDF]

, 2017
Ai, Teresa L, Bennion, Brock G, Gonugunta, Vijay K, Irizarry-Caro, Ricardo A, Miner, Cathrine A, Miner, Jonathan J, Platt, Derek J, Sakai, Tomomi, Smith, Amber M, Warner, James D, Wu, Jianjun, Yan, Nan   +11 more
core   +1 more source

Automodification of N‐terminal serine residues facilitates PARP2 release from DNA

The FEBS Journal, EarlyView.
PARP2 is involved in detecting DNA damage and its N‐terminal role is largely unknown. Based on biochemical and biophysical data, our findings suggest that in the presence of HPF1, N‐terminal serine 8 and 73 are enriched in auto‐ADP‐ribosylation. Our results provide insight into the mechanistic role of PARP2 N‐terminus in the PARylation‐dependent ...
Saurabh Singh Dhakar, Albert Galera‐Prat, Jin Cai, Julia Preisser, Tiila‐Riikka Kiema, Andreas Ladurner, Lari Lehtiö   +6 more
wiley   +1 more source

Steroidogenic compensation and lipid deficiency with enhanced NAD+ salvage in small‐for‐gestational‐age placenta

The FEBS Journal, EarlyView.
Fetal growth restriction is associated with placental metabolic adaptations. In small‐for‐gestational‐age placenta (SGA), cholesterol receptors and steroidogenic enzymes are upregulated, enhancing steroidogenesis. NAD salvage pathway is also increased to support NADP+/NADPH requirements.
Serena Xodo, Lorenza Driul, Vanessa Tolotto, Eros Di Giorgio, Luigi E. Xodo   +4 more
wiley   +1 more source

cGAS-STING signaling: a therapeutic target in inflammatory bowel disease and related colorectal cancer. [PDF]

Front Immunol
Chen X, Tang X, Chen S, Ye Y, Mao F.
europepmc   +1 more source

Resveratrol Mitigates Age-Associated Cognitive Decline via Inhibition of cGAS-STING-Mediated Microglial Senescence. [PDF]

Cells
Duan X, Cheng J, Wang J, Chen W, Ruan Z.
europepmc   +1 more source

Nanostructured branched Y-DNA promotes antitumor immunity through dual activation of cGAS/STING and TLR9. [PDF]

Arch Pharm Res
Seok JK, Jee JI, Oh JH, Ahn SY, Cho H, Yang YE, Kim M, Kwon HJ, Cho YY, Lee HS, Um SH, Kang HC, Lee JY.   +12 more
europepmc   +1 more source