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Protective effects of human umbilical cord mesenchymal stem cells-derived small extracelluar vesicles on corneal epithelial cells under hyperosmotic stress: Inhibition of oxidative damage and inflammation. [PDF]
Genet Mol BiolPeng C +5 more
europepmc +1 more source
Correction to "The Activation of cGAS-STING Pathway Causes Abnormal Uterine Receptivity in Aged Mice". [PDF]
Aging Celleuropepmc +1 more source
Intestinal STING‐(Over)activation—A Contributing Factor to Food Allergies?
Allergy, EarlyView.
Sophie Goebel, Hannah Ruth Schiller
wiley +1 more source
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Current Biology, 2022
Cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING, also known as TMEM173) constitute the major signaling pathway in vertebrates that senses non-self DNA and elicits potent immune responses. At the core of this pathway, cGAS senses double-stranded DNA (dsDNA) and synthesizes cyclic GMP-AMP (cGAMP).
Zhiqi, Sun, Veit, Hornung
openaire +2 more sources
Cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING, also known as TMEM173) constitute the major signaling pathway in vertebrates that senses non-self DNA and elicits potent immune responses. At the core of this pathway, cGAS senses double-stranded DNA (dsDNA) and synthesizes cyclic GMP-AMP (cGAMP).
Zhiqi, Sun, Veit, Hornung
openaire +2 more sources
Interplay of cGAS with chromatin
Trends in Biochemical Sciences, 2021Recognition of DNA is an evolutionarily highly conserved mechanism of immunity. In mammals, the cGAS-STING pathway plays a central role in coupling DNA sensing to the execution of innate immune mechanisms, both in contexts of infection as well as in noninfectious settings of cellular stress and injury. The indiscriminate ability of double-stranded DNA (
Wischnewski, Marilena, Ablasser, Andrea
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CS-CGA: Compact and more Secure CGA
2011 17th IEEE International Conference on Networks, 2011Cryptographically Generated Address (CGA) is one of the most novel security features introduced in IPv6 suite. CGA is designed to prevent addresses theft without relying on trust authority or additional security infrastructures. However, CGA is relatively computationally intensive, and bandwidth consuming.
Ahmad AlSa'deh +2 more
openaire +1 more source
Step on the cGAS! Viral inhibition of cGAS phase separation with cytosolic DNA
Molecular Cell, 2021Xu et al. (2021) uncover a conserved viral mechanism to subvert the innate immune system whereby herpesvirus tegument proteins suppress cGAS:DNA phase separation.
Shubhanjali, Minhas, Alex S, Holehouse
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Demystifying the cGAS-STING pathway: precision regulation in the tumor immune microenvironment
Molecular CancerThe cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway serves as an immune sentinel for cytosolic DNA, recognizing double-stranded DNA (dsDNA) derived from abnormally localized nuclear DNA or mitochondrial DNA (mtDNA),
Qingyang Wang +4 more
semanticscholar +1 more source
Nature Immunology, 2016
The detection of cytosolic DNA by the sensor cGAS triggers potent antiviral responses. New data now propose that cGAS is regulated on a post-translational level by glutamylation.
openaire +4 more sources
The detection of cytosolic DNA by the sensor cGAS triggers potent antiviral responses. New data now propose that cGAS is regulated on a post-translational level by glutamylation.
openaire +4 more sources