Results 271 to 280 of about 42,468 (308)
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Nature Reviews Molecular Cell Biology, 2018
Cyclic GMP–AMP synthase (cGAS) inhibits DNA damage repair in the nucleus and thereby promotes tumorigenesis.
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Cyclic GMP–AMP synthase (cGAS) inhibits DNA damage repair in the nucleus and thereby promotes tumorigenesis.
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cGAS Conducts Micronuclei DNA Surveillance
Trends in Cell Biology, 2017DNA damage elicits a potent proinflammatory immune response. A collection of four papers now reveals that micronuclear DNA is a new cell intrinsic immunostimulatory molecule, and that accumulation of the immune sensor cyclic GMP-AMP synthase (cGAS) in micronuclei leads to a cell-cycle-dependent proinflammatory response following DNA damage.
Carina C, de Oliveira Mann +1 more
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Science, 2021
Innate Immunity Cells detect microbial and self-DNA in the cytosol as a danger signal that triggers immune and inflammatory responses. Paradoxically, a large fraction of a DNA-sensing enzyme called cGAS is tightly associated with the chromatin, especially during mitosis. Li et al.
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Innate Immunity Cells detect microbial and self-DNA in the cytosol as a danger signal that triggers immune and inflammatory responses. Paradoxically, a large fraction of a DNA-sensing enzyme called cGAS is tightly associated with the chromatin, especially during mitosis. Li et al.
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Science Signaling
The DNA double-strand break sensor MRE11 is necessary to liberate cGAS and enable its activation by dsDNA.
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The DNA double-strand break sensor MRE11 is necessary to liberate cGAS and enable its activation by dsDNA.
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Science-Business eXchange, 2013
University of Texas Southwestern Medical Center researchers have confirmed the role of cyclic GMP-AMP signaling in the innate immune system, making a case for developing adjuvants that agonize the pathway or antagonists of the pathway to treat autoimmune conditions.
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University of Texas Southwestern Medical Center researchers have confirmed the role of cyclic GMP-AMP signaling in the innate immune system, making a case for developing adjuvants that agonize the pathway or antagonists of the pathway to treat autoimmune conditions.
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The cGAS–STING pathway as a therapeutic target in inflammatory diseases
Nature Reviews Immunology, 2021Alexiane Decout, Andrea Ablasser
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