Results 271 to 280 of about 52,090 (308)

Decomposable Nanoagonists Enable NIR‐Elicited cGAS‐STING Activation for Tandem‐Amplified Photodynamic‐Metalloimmunotherapy

Advances in Materials
Activation of the cyclic GMP‐AMP synthase‐stimulator of interferon genes (cGAS‐STING) pathway has emerged as an efficient strategy to improve the therapeutic outcomes of immunotherapy.
Xun Guo, Peng Tu, Xiaoting Wang, Chier Du, Weixi Jiang, Xiaoling Qiu, Jingxue Wang, Liang Chen, Yu Chen, Jianli Ren   +9 more
semanticscholar   +1 more source

Loosening the grip on nuclear cGAS

Nature Genetics, 2020
Maintaining ignorance to self-nucleic acids can prevent inflammatory diseases such as Aicardi–Goutieres syndrome (AGS). A new study finds that mutations in LSM11 and RNU7-1, which encode components of the histone messenger RNA–preprocessing complex, cause AGS by loosening the binding of cyclic GMP–AMP synthase (cGAS) to nucleosomes, thus enabling cGAS ...
Fiachra Humphries, Katherine A. Fitzgerald   +1 more
openaire   +2 more sources

ATP‐Responsive Manganese‐Based Bacterial Materials Synergistically Activate the cGAS‐STING Pathway for Tumor Immunotherapy

Advances in Materials
Stimulating the cyclic guanosine monophophate(GMP)‐adenosine monophosphate (AMP) synthase (cGAS)‐stimulator of interferon genes (STING) pathway is a crucial strategy by which bacteria activate the tumor immune system.
Huang Yang, Sisi Yang, Quanshi Guo, Jifang Sheng, Zhengwei Mao   +4 more
semanticscholar   +1 more source

Identification and functional characterization of cGAS and cGAS-like in snakehead Channa argus

Fish & Shellfish Immunology
In mammals, cyclic GMP-AMP synthase (cGAS) senses cytosolic dsDNA to trigger type I interferon (IFN) response via the sting signalling, but its regulatory role in fish remains unclear. In the present study, cGAS and cGAS-like (cGASL) were identified in the snakehead (Channa argus), but they differ in the organization of two domains, NTase domain, MAB21
Hong Qing Zhang, Long Wei Cai, Yu Hang Deng, Meng Xin Yan, Peng Fei Mu, Bo Li, Lan Hao Liu, P. Nie   +7 more
openaire   +2 more sources

cGAS/STING signalling pathway in senescence and oncogenesis

Seminars in Cancer Biology
The cGAS/STING signaling pathway is a crucial component of the innate immune system, playing significant roles in sensing cytosolic DNA, regulating cellular senescence, and contributing to oncogenesis.
Le Yu, Pengda Liu
semanticscholar   +1 more source

A children's global assessment scale (CGAS).

Archives of General Psychiatry, 1983
D. Shaffer, M. Gould, James Robert Brašić, P. Ambrosini, P. Fisher, H. Bird, S. Aluwahlia   +6 more
semanticscholar   +1 more source

Methionine restriction promotes cGAS activation and chromatin untethering through demethylation to enhance antitumor immunity

Cancer Cell, 2023
Xuemei Gu
exaly  

Regulation of cGAS–STING signalling and its diversity of cellular outcomes

Nature reviews. Immunology
Zhengying Zhang, Conggang Zhang
semanticscholar   +1 more source

CGAS

2007
Kwangmin Choi, Youngik Yang, Sun Kim
openaire   +1 more source

TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS

Cell, 2020
Jonas Moecking, Bradley Turner, Cynthia Louis   +2 more
exaly