Results 281 to 290 of about 42,468 (308)
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Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity
Cell, 2023Carl W Tong +2 more
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Keeping cGAS in check: SPSB3 promotes nuclear cGAS degradation for maintaining immune homeostasis
Molecular CellIn a recent publication in Nature, Xu et al.1 discovered a role of CRL5-SPSB3 ubiquitin ligase in promoting ubiquitination and degradation of nuclear cGAS, which prevents aberrant cGAS activation by genomic DNA and contributes to the maintenance of immune homeostasis.
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Molecular mechanisms and cellular functions of cGAS–STING signalling
Nature Reviews Molecular Cell Biology, 2020Karl-Peter Hopfner, Veit Hornung
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TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS
Cell, 2020Chien-Hsiung Yu +2 more
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MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway
Cancer Cell, 2021Junhong Guan, Changzheng Lu, Huiming Lu
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Bacteriophages inhibit and evade cGAS-like immune function in bacteria
Cell, 2023Erin Huiting +2 more
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Acetylation Blocks cGAS Activity and Inhibits Self-DNA-Induced Autoimmunity
Cell, 2019Xinhua He, Ming Zhao, Kun He
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The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death
Cell, 2019Christian Zierhut +2 more
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