Results 261 to 270 of about 52,090 (308)
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The cGAS‒STING pathway in cancer immunity: mechanisms, challenges, and therapeutic implications
Journal of Hematology & OncologyInnate immunity represents the body’s first line of defense, effectively countering the invasion of external pathogens. Recent studies have highlighted the crucial role of innate immunity in antitumor defense, beyond its established function in ...
Mengzhou Shen +9 more
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Advances in Materials
The cGAS‐STING pathway is pivotal in initiating antitumor immunity. However, tumor metabolism, particularly glycolysis, negatively regulates the activation of the cGAS‐STING pathway.
Nailin Yang +12 more
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The cGAS‐STING pathway is pivotal in initiating antitumor immunity. However, tumor metabolism, particularly glycolysis, negatively regulates the activation of the cGAS‐STING pathway.
Nailin Yang +12 more
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Cellular functions of cGAS-STING signaling.
Trends in Cell Biology, 2022Cyclic GMP-AMP (cGAMP) synthase (cGAS) senses misplaced genomic, mitochondrial, and microbial double-stranded DNA (dsDNA) to synthesize 2'3'-cGAMP that mobilizes stimulator of interferon genes (STING) to unleash innate immune responses, constituting a ...
Chen Chen, Pinglong Xu
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Nature Reviews Rheumatology, 2019
Sensing of cytosolic DNA by cyclic GMP–AMP synthase (cGAS) is central to the pathogenesis of a number of autoinflammatory syndromes and possibly some autoimmune diseases, such as systemic lupus erythematosus (SLE). Activation of cGAS signalling requires its deacetylation, so might aspirin have therapeutic potential to treat SLE by acetylating cGAS?
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Sensing of cytosolic DNA by cyclic GMP–AMP synthase (cGAS) is central to the pathogenesis of a number of autoinflammatory syndromes and possibly some autoimmune diseases, such as systemic lupus erythematosus (SLE). Activation of cGAS signalling requires its deacetylation, so might aspirin have therapeutic potential to treat SLE by acetylating cGAS?
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Journal of the American Chemical Society
The immunosuppressive tumor microenvironment (TME) significantly limits the efficacy of cancer immunotherapy. Activation of the cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS) stimulator of interferon genes (STING) pathway and ...
Qian‐Ru Li +9 more
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The immunosuppressive tumor microenvironment (TME) significantly limits the efficacy of cancer immunotherapy. Activation of the cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS) stimulator of interferon genes (STING) pathway and ...
Qian‐Ru Li +9 more
semanticscholar +1 more source
Nature Reviews Molecular Cell Biology, 2018
Cyclic GMP–AMP synthase (cGAS) inhibits DNA damage repair in the nucleus and thereby promotes tumorigenesis.
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Cyclic GMP–AMP synthase (cGAS) inhibits DNA damage repair in the nucleus and thereby promotes tumorigenesis.
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Science
A DNA repair function in a cytosolic sensor demonstrates a potential role in naked mole-rat ...
John C, Martinez +2 more
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A DNA repair function in a cytosolic sensor demonstrates a potential role in naked mole-rat ...
John C, Martinez +2 more
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Science Signaling
The DNA double-strand break sensor MRE11 is necessary to liberate cGAS and enable its activation by dsDNA.
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The DNA double-strand break sensor MRE11 is necessary to liberate cGAS and enable its activation by dsDNA.
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Immunity
Induction of autophagy is an ancient function of the cyclic GMP-AMP (cGAMP) synthase (cGAS)-stimulator of interferon genes (STING) pathway through which autophagic cargoes are delivered to lysosomes for degradation.
Yinfeng Xu +9 more
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Induction of autophagy is an ancient function of the cyclic GMP-AMP (cGAMP) synthase (cGAS)-stimulator of interferon genes (STING) pathway through which autophagic cargoes are delivered to lysosomes for degradation.
Yinfeng Xu +9 more
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The chromogranin-A (CgA) in prostate cancer
Archives of Gerontology and Geriatrics, 2006Prostate cancer is one of the most frequent tumors in men. The neuroendocrine differentiation in prostate cancer has become more widely recognized and has attracted considerable attention as a potentially new finding with major diagnostic, prognostic and therapeutic implications. We investigated the role of the serum concentrations of CgA in a group of
RANNO S +5 more
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