Results 261 to 270 of about 42,468 (308)
Dual-targeted manganese-doped carbon dots activate the cGAS-STING pathway and immunogenic cell death for potent glioblastoma immunotherapy. [PDF]
Mater Today BioLi Z +10 more
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Electroacupuncture Attenuates Neuroinflammation and Postoperative Cognitive Dysfunction in Aged Rats by Suppressing the cGAS-STING Pathway. [PDF]
Exp NeurobiolMa B +6 more
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An atlas of cGAS-STING signaling in pathophysiological angiogenesis and retinal vascular homeostasis across species. [PDF]
Mol Ther Nucleic AcidsHe X +11 more
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Current Biology, 2022
Cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING, also known as TMEM173) constitute the major signaling pathway in vertebrates that senses non-self DNA and elicits potent immune responses. At the core of this pathway, cGAS senses double-stranded DNA (dsDNA) and synthesizes cyclic GMP-AMP (cGAMP).
Zhiqi, Sun, Veit, Hornung
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Cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING, also known as TMEM173) constitute the major signaling pathway in vertebrates that senses non-self DNA and elicits potent immune responses. At the core of this pathway, cGAS senses double-stranded DNA (dsDNA) and synthesizes cyclic GMP-AMP (cGAMP).
Zhiqi, Sun, Veit, Hornung
openaire +2 more sources
CS-CGA: Compact and more Secure CGA
2011 17th IEEE International Conference on Networks, 2011Cryptographically Generated Address (CGA) is one of the most novel security features introduced in IPv6 suite. CGA is designed to prevent addresses theft without relying on trust authority or additional security infrastructures. However, CGA is relatively computationally intensive, and bandwidth consuming.
Ahmad AlSa'deh +2 more
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Interplay of cGAS with chromatin
Trends in Biochemical Sciences, 2021Recognition of DNA is an evolutionarily highly conserved mechanism of immunity. In mammals, the cGAS-STING pathway plays a central role in coupling DNA sensing to the execution of innate immune mechanisms, both in contexts of infection as well as in noninfectious settings of cellular stress and injury. The indiscriminate ability of double-stranded DNA (
Wischnewski, Marilena, Ablasser, Andrea
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Nature Reviews Rheumatology, 2019
Sensing of cytosolic DNA by cyclic GMP–AMP synthase (cGAS) is central to the pathogenesis of a number of autoinflammatory syndromes and possibly some autoimmune diseases, such as systemic lupus erythematosus (SLE). Activation of cGAS signalling requires its deacetylation, so might aspirin have therapeutic potential to treat SLE by acetylating cGAS?
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Sensing of cytosolic DNA by cyclic GMP–AMP synthase (cGAS) is central to the pathogenesis of a number of autoinflammatory syndromes and possibly some autoimmune diseases, such as systemic lupus erythematosus (SLE). Activation of cGAS signalling requires its deacetylation, so might aspirin have therapeutic potential to treat SLE by acetylating cGAS?
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Nature Immunology, 2016
The detection of cytosolic DNA by the sensor cGAS triggers potent antiviral responses. New data now propose that cGAS is regulated on a post-translational level by glutamylation.
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The detection of cytosolic DNA by the sensor cGAS triggers potent antiviral responses. New data now propose that cGAS is regulated on a post-translational level by glutamylation.
openaire +2 more sources