Results 251 to 260 of about 24,434 (294)

Effectiveness and Toxicity of Anticancer Agents in Older Australian Patients: A Retrospective Analysis

Asia-Pacific Journal of Clinical Oncology, EarlyView.
We conducted a retrospective observational analysis of patients ≥75 years. To our knowledge, this is the first study providing real‐world data on the efficacy, and safety, of anti‐cancer agents in older patients in a regional Australian center across multiple tumor streams.
Joseph S. Taylor, Cassandra White, Larissa Collins, Benjamin Moran, Craig Kukard   +4 more
wiley   +1 more source

RIG-I and cGAS mediate antimicrobial and inflammatory responses of primary osteoblasts and osteoclasts to <i>Staphylococcus aureus</i>. [PDF]

mBio
Mills EL, Suptela SR, Key M-K, Marriott I, Johnson MB.   +4 more
europepmc   +1 more source

BLOC1S1 Control of Vacuolar Organelle Fidelity Modulates Murine TH2 Cell Immunity and Allergy Susceptibility

Allergy, EarlyView.
Abbreviations: BLOC1S1, biogenesis of lysosome organelles complex 1 subunit 1; cGAS, cyclic GMP‐AMP synthase; GATA3, GATA binding protein 3; IgE, immunoglobulin E; IKK, inhibitor of nuclear factor kappa‐B kinase; IL, interleukin; mtDNA, mitochondrial DNA; NF‐κB, nuclear factor‐kappa B; OVA, ovalbumin; MC903, vitamin D3 analog; STING, stimulator of ...
Rahul Sharma, Kaiyuan Wu, Kim Han, Anna Chiara Russo, Pradeep K. Dagur, Christian A. Combs, Xianglan Yao, Stewart J. Levine, Michael N. Sack   +8 more
wiley   +1 more source

Rutin ameliorates LPS-induced acute lung injury in mice by inhibiting the cGAS-STING-NLRP3 signaling pathway. [PDF]

Front Pharmacol
Zhou X, Wang Z, Wang Y, Xu G, Luo M, Zhang M, Li Y.   +6 more
europepmc   +1 more source

Phenotype and gene signature of testicular tumors in 129.MOLF‐Chr19 mice resemble human teratomas

Andrology, EarlyView.
Abstract Background Testicular germ cell tumor (TGCT) is the most common type of tumor in young men. Type II germ cell tumors including postpubertal‐type teratomas are derived from the germ cell neoplasia in situ (GCNIS), whereas prepubertal‐type teratomas arise independently of the GCNIS.
Fabian A. Gayer, Lucas Klaus, Sybille D. Reichardt, Alexander Fichtner, Holger M. Reichardt   +4 more
wiley   +1 more source

The cGAS‒STING pathway in cancer immunity: mechanisms, challenges, and therapeutic implications. [PDF]

J Hematol Oncol
Shen M, Jiang X, Peng Q, Oyang L, Ren Z, Wang J, Peng M, Zhou Y, Deng X, Liao Q.   +9 more
europepmc   +1 more source

Innovative pharmacotherapy for hepatic metabolic and chronic inflammatory diseases in China

British Journal of Pharmacology, EarlyView.
Abstract Liver disease constitutes a significant global health concern, particularly in China where it has distinctive characteristics. China grapples with a staggering 300 million cases, predominantly due to hepatitis B and metabolic non‐alcoholic fatty liver disease. Additionally, hepatocellular carcinoma has become a prevalent which is a lethal type
Feng Zhang, Jiaming Ju, Hongtao Diao, Jinglun Song, Yu bian, Baofeng Yang   +5 more
wiley   +1 more source

Birch pollen allergen-induced dsDNA release activates cGAS-STING signaling and type 2 immune response in mice. [PDF]

iScience
Chenuet P, Mellier M, Messaoud-Nacer Y, Culerier E, Marquant Q, Fauconnier L, Rouxel N, Ledru A, Rose S, Ryffel B, Apetoh L, Quesniaux VFJ, Togbe D.   +12 more
europepmc   +1 more source

The Role of Histone Methyltransferase SETDB1 in Normal and Malignant Hematopoiesis

Cancer Science, EarlyView.
In this review, we discuss the role of SETDB1 in gene regulation, including an overview of its structural features and key cofactors. We also highlight the lineage‐specific roles of SETDB1 in both normal hematopoietic processes and hematological malignancies, emphasizing its function as an immune checkpoint molecule that suppresses natural killer cell ...
Yu‐Hsuan Chang, Susumu Goyama
wiley   +1 more source